Protein Alignment Elk and KCNH1

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_758872.1
• Gene: KCNH1 / 3756
• HGNCID: 6250
• Length: 989
• Species: Homo sapiens
• Alignment Length: 1088
• Identity: 337/1088 - (30%)
• Similarity: 520/1088 - (47%)
• Gaps: 250/1088 - (22%)

  Fly     4 RKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCSCHF 68
            |:||:|||||||:.|..|.:.|  ||||||||....||||.:|||..|:||.||::|||..:|.|
Human     7 RRGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSF 69

  Fly    69 LYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHKDIT 133
            :||..|.::..:::.::..|......|::.|||...|.|....|.||:||:..|||||.:..|||
Human    70 MYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDIT 134

  Fly   134 HTKM-LEMNVNEECD--SVFA-LTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            ..|. :|   ::.|.  ..|| ||.||..
Human   135 AFKQPIE---DDSCKGWGKFARLTRALTS------------------------------------ 160

  Fly   195 NLDVPAGCNMGRRRSRAVLYQLS-----GHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIK 254
                          ||.||.||:     |....:...:...|:||::.:       |:||.::.|
Human   161 --------------SRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDIL-------PQYKQEAPK 204

  Fly   255 KSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTKVS----DVIVEALFIVDILL 315
            ....|:.||.|||..|||:||:.|||.|::||||.:|  ..||..|:    |.||:.:|:|||:|
Human   205 TPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDIVL 267

  Fly   316 NFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYD---------------- 364
            ||.||||...|||:|:.|.|.:|||:.||.:|||:.||:|.:.|.:..|
Human   268 NFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFAD 332

  Fly   365 ------------GEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIW 417
                        |..|....:|:.|||||.|:.:|:|.|.::.|.:|.||:..|.|||||:||||
Human   333 QIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIW 397

  Fly   418 YVIAVKEYEWFPES-----NIGWLQLLA--------------------ERKNASVAILTTAETYS 457
            |  ::.:||.|.|.     |..||..||                    ..||:         .|.
Human   398 Y--SIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNS---------VYI 451

  Fly   458 TALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKW 522
            ::||||.||||||||||::.:|..||:|.:.:|:||:|::|.:|||||.|.|:||:..:.|....
Human   452 SSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEML 516

  Fly   523 RDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPI 586
            ..::||:.|:.:||.|.:|:.||..::||:|.|||..:.|:..|:::|.|:.:||:|::. :.|.
Human   517 NSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPA 581

  Fly   587 FEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGS 651
            |..||.|||:.|::..:|..||||:.:.|.|::::.:.::.:||:|||:||.|||||||||:.|
Human   582 FRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFG- 645

  Fly   652 DINVHLVATSNGQMTATTNSAGQDV------VVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEY 710
                                   ||      :.:|.::::|||||||..|....|.:||..|..:
Human   646 -----------------------DVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF 687

  Fly   711 QQQFANDIQHDLTCNLRE--------GYENQDSD-----------IGPSFPLPSI----SEDDEN 752
            ...|:.::  .||.|||:        ..:.::.:           :.|..|:..:    .:..|.
Human   688 SHSFSRNL--ILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEA 750

  Fly   753 REEAEEGGKG----EKENGGGPPSGASPLHNISNSPLHATR-SPLLGM--------GSPRNQRLH 804
            |..||.||:.    :.|.|......||..|::..:.:...| ||...:        |.|.:.:|.
Human   751 RLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQ 815

  Fly   805 QRGRSLITLR------ETNKRHRTLNAAC--SLDRGSFEEPEPLE--EEQSSGGKRPSLERLDSQ 859
            ..|...:..:      ...|.......||  |.|.....:.|.:|  .|::......:|::.||.
Human   816 APGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSC 880

  Fly   860 VSTL---------------HQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNIS 909
            .|.:               .||.:.:.|||:::...:.|.|..:..:.....||       .:|.
Human   881 DSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELK-------EDIK 938

  Fly   910 GVAGTRSGVAVEHGLMGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTS 957
            .:....:.:..:   :..:|   .:...:|||..|.|::  ::..|.|
Human   939 ALNAKMTNIEKQ---LSEIL---RILTSRRSSQSPQELF--EISRPQS 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	38/92 (41%)
		PLN03192	270..>650	CDD:215625	175/437 (40%)
		cNMP	586..716	CDD:197516	47/135 (35%)
KCNH1	NP_758872.1	PAS_9	41..135	CDD:463873	39/93 (42%)
		Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000269|PubMed:27005320	151..162		6/60 (10%)
		PLN03192	220..>647	CDD:215625	176/463 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472	463..468		4/4 (100%)
		PRK11753	608..>712	CDD:236969	40/129 (31%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:10880439	673..770		19/98 (19%)
		Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000250|UniProtKB:Q60603	699..701		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..886		7/30 (23%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250|UniProtKB:Q63472	924..964		5/52 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989		7/19 (37%)