DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Ih

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster

Alignment Length:	670	Identity:	146/670 - (21%)
Similarity:	279/670 - (41%)	Gaps:	146/670 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 QLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATF 279
            ||...::|      |..:|......|.:|...|...|......:|.| ...|:..||..:|:...
  Fly   708 QLQSWFQP------TDNRLAMKLFGSRKALVKERIRQKTSGHWVIHP-CSSFRFYWDLCMLLLLV 765

  Fly   280 YVALMVPYNAAFAKADRQTK--VSDVIVEALFIVDILLNFRTTFVSRKG--EVVSNSKQIAINYL 340
            ...:::|...:|...|..|:  ..:.:.:.:|::||::||||..:.:..  :|:.:.|.||.:||
  Fly   766 ANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKHYL 830

  Fly   341 RGWFALDLLAALPFDHLY-----ASDLYDGEDSH--IH------------LVKLTRLLRLARLLQ 386
            |.||.|||::::|.|:::     ...|.|..||.  :|            |:.|.|||||:||::
  Fly   831 RTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRLVR 895

  Fly   387 KIDRYSQ---------------------------HTAMILTLLMFS------------FTLAAHW 412
            .:.::.:                           .:.:||..|..:            ..|..||
  Fly   896 YVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIGHW 960

  Fly   413 LACIWYVIAVKEYEWFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSA 477
            ..|:.:::.:  .:.||.::  |:.:...:::..:      |.||.||:...:.:..:|:|....
  Fly   961 SGCLQFLVPM--LQGFPSNS--WVSINELQESYWL------EQYSWALFKAMSHMLCIGYGRFPP 1015

  Fly   478 NTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRI 542
            .:..:...|::.|:.||..:|:..|:.|.:||.:.|.|..|..|.:.:::::|...:|::::|||
  Fly  1016 QSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLPRDMRQRI 1080

  Fly   543 EDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNF 606
            .:||:..:. ....|....|.|..|:||.||..:..|.:: .:|.|..|....:..:...:|...
  Fly  1081 TEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLKYEV 1144

  Fly   607 CAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATS------NGQM 665
            ..||:.:|.:|.....:|::..|.:::        ::..|:          ||||      .|::
  Fly  1145 FQPGDIIIKEGTIGTKMYFIQEGVVDI--------VMANGE----------VATSLSDGSYFGEI 1191

  Fly   666 TATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFAN-------------D 717
            ...||:       |..:.::|.|||:|..:.:.....||..||..::....             :
  Fly  1192 CLLTNA-------RRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPN 1249

  Fly   718 IQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKEN--GGGPPSGASPLHNI 780
            |.|...    |...|.:|:...:......:|.|:.:::..:    .|||  .|...|.|.|:..|
  Fly  1250 IMHQKD----EQLSNPESNTITAVVNALAAEADDCKDDDMD----LKENLLHGSESSIAEPVQTI 1306

  Fly   781 SNSPLHATRSPLLGMGSPRN 800
            ..           |:..||:
  Fly  1307 RE-----------GLPRPRS 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	66/292 (23%)
		Ion_trans_2	<455..510	CDD:285168	14/54 (26%)
		Crp	583..>650	CDD:223736	11/66 (17%)
		CAP_ED	586..715	CDD:237999	27/134 (20%)
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	10/48 (21%)
		Ion_trans	771..1054	CDD:278921	66/292 (23%)
		Crp	1118..>1241	CDD:223736	28/147 (19%)
		CAP_ED	1124..1233	CDD:237999	27/133 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740