Protein Alignment Elk and HCN1

DIOPT Version :9

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_066550.2
• Gene: HCN1 / 348980
• HGNCID: 4845
• Length: 890
• Species: Homo sapiens
• Alignment Length: 1017
• Identity: 220/1017 - (21%)
• Similarity: 397/1017 - (39%)
• Gaps: 261/1017 - (25%)

  Fly   141 NVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASD-----------GDTEAGEGN 194
            |..::.:|||...|:..|    ||..|....||..||.||..|.:           |....|.|.
Human    12 NSRDDGNSVFPAKASATG----AGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGG 72

  Fly   195 NLDVPAG----CNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKK 255
            ..:.|||    ....||:...:..|.:...:|   ||.   |.......|.:|  .|.:.:.:|.
Human    73 GGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQP---GVN---KFSLRMFGSQKA--VEKEQERVKT 129

  Fly   256 SRLILPH-YGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK--VSDVIVEALFIVDILLNF 317
            :...:.| |..|:..||.::|:......:::|....|......|.  :.:|..:.:|::|:::||
Human   130 AGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNF 194

  Fly   318 RTTFVSR-KGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIH---------- 371
            ||..|:. ..|::.:.|.|.:|||:.||.:|.::::|.|:::.. :..|.||.::
Human   195 RTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLI-VEKGMDSEVYKTARALRIVR 258

  Fly   372 ---LVKLTRLLRLARLLQKIDRYSQHTAMILTL---------LMFSFTLAAHWLACIWYVIAVKE 424
               ::.|.|||||:||::.|.::.:...|...|         |:....|..||..|:.:::.:.:
Human   259 FTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQ 323

  Fly   425 YEWFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIM 489
             ::.|:.   |:. |.|..|.|     ..:.||.||:...:.:..:|:|..:..:.::...|::.
Human   324 -DFPPDC---WVS-LNEMVNDS-----WGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLS 378

  Fly   490 MLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSH 554
            |::||..:|:..|:.||:||.:.|.|..|:.|::.::.:::.|.:|.:::|:|.||::..:. ..
Human   379 MIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GK 442

  Fly   555 GIDIYETLREFPEELRGD-VSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGD 618
            ..|....|.|..:.||.: |:.:..:.:..:|:|..|....:..:...::.....||:|:|.:|.
Human   443 IFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGA 507

  Fly   619 ALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSD 683
            ....:|::.:|...||........|..|...|     .:...:.|:.||:
Human   508 VGKKMYFIQHGVAGVITKSSKEMKLTDGSYFG-----EICLLTKGRRTAS--------------- 552

  Fly   684 IKALTYCDLKCIHMGGLVEVLRLYPEYQQQF-------------ANDI-----QHDLTCNLREGY 730
            ::|.|||.|..:.:....|||..||..::.|             .|.|     |.||...:   :
Human   553 VRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGV---F 614

  Fly   731 ENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGM 795
            .||:::|     |..|.:.|....:|                 .:|::....:.|::|.|
Human   615 NNQENEI-----LKQIVKHDREMVQA-----------------IAPINYPQMTTLNSTSS----- 652

  Fly   796 GSPRNQRLHQRGRSLITLRETNKRHRT----LNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERL 856
                            |...|: |.||    :..|.||...:...|.|     |:...:||
Human   653 ----------------TTTPTS-RMRTQSPPVYTATSLSHSNLHSPSP-----STQTPQPS---- 691

  Fly   857 DSQVSTLHQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVE 921
             :.:|......|..|..|::.::|   .||...:.|
Human   692 -AILSPCSYTTAVCSPPVQSPLAA---RTFHYASPT----------------------------- 723

  Fly   922 HGLMGGVLAAAELAAMQR------SSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQ 980
                     |::|:.||:      ..|.||:...:... |...|..|..|      |....:|:|
Human   724 ---------ASQLSLMQQQPQQQVQQSQPPQTQPQQPS-PQPQTPGSSTP------KNEVHKSTQ 772

  Fly   981 TDFYRIDFPTFERFVLANPRL---VLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVS---- 1038
                          .|.|..|   |..|...:|::.:|:      .||...|..|:.|.::
Human   773 --------------ALHNTNLTREVRPLSASQPSLPHEV------STLISRPHPTVGESLASIPQ 817

  Fly  1039 -----PSDHNLASSKE---------RLITSSAVPTPGRIYPP 1066
                 |.....|..:.         |.::|.|:| |.|..||
Human   818 PVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIP-PNRGVPP 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	64/255 (25%)
		Ion_trans_2	<455..510	CDD:285168	15/54 (28%)
		Crp	583..>650	CDD:223736	14/66 (21%)
		CAP_ED	586..715	CDD:237999	28/141 (20%)
HCN1	NP_066550.2	Disordered. /evidence=ECO:0000305|PubMed:28086084	1..93		24/84 (29%)
		Ion_trans_N	98..140	CDD:285597	10/49 (20%)
		Ion_trans	160..405	CDD:278921	64/255 (25%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28086084	358..362		1/3 (33%)
		Crp	469..>604	CDD:223736	31/154 (20%)
		CAP_ED	475..583	CDD:237999	27/127 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..692		16/79 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..796		19/91 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..890		7/15 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740