DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Cngb1

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001182342.1	Gene:	Cngb1 / 333329	MGIID:	2664102	Length:	1325	Species:	Mus musculus

Alignment Length:	894	Identity:	169/894 - (18%)
Similarity:	325/894 - (36%)	Gaps:	228/894 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHKDITHTK 136
            |:.|||.:::.|:....:.|.|.|.:..|:||.                      |::..:..||
Mouse   496 PEEKEEKEEEKEEEKEEEEEKKEEEVEKKEEGE----------------------ATNSTVPATK 538

  Fly   137 -MLEMNVNE-------------------------ECDSVFALTAALLGARFRAGSNAGML-GLGG 174
             ..|:.|.:                         :.|::....||..|.|.:..|..... .|..
Mouse   539 EHPELQVEDTDADSGPLIPEETLPPPERPPPSPVKSDTLTVPGAAAAGHRKKLPSQDDEAEELKA 603

  Fly   175 LPGLGGPAASDGD-TEAGEGNNLDVPAGCNMGRRRSRAV---LYQLSGHYKPEKGGVKTKLKLGN 235
            |.....|..:..| |...|.:..|..|  :...:.|..:   |.:|...:|.....||.|| :..
Mouse   604 LSPAESPVVAWSDPTTPQEADGQDRAA--STASQNSAIINDRLQELVKMFKERTEKVKEKL-IDP 665

  Fly   236 NFMHSTEAPFP--------------------------------EYKTQSIKKSRL---ILPHYGV 265
            :.....|:|.|                                ::|.:.:|..|.   |.|...:
Mouse   666 DVTSDEESPKPSPAKKAPEPDPAQKPAEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNL 730

  Fly   266 FKGIWDWVILVATFYVALMVPYNAAF--AKAD--RQTKVSDVIVEALFIVDI-LLNFRTTFVSRK 325
            ...:|.:.:::|..:...::|...||  .:||  ....:.|.:.:.::::|| :...|..|| :.
Mouse   731 MYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHFWLLMDYLCDFIYLLDITVFQMRLQFV-KG 794

  Fly   326 GEVVSNSKQIAINYLRG-WFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLL---------- 379
            |:::::.|::..|||:. .|.:|||..||.|.||   |..|.:.   |::|.|.|
Mouse   795 GDIITDKKEMRNNYLKSRRFKMDLLCLLPLDFLY---LKLGINP---LLRLPRCLKYMAFFEFNN 853

  Fly   380 RLARLLQK--IDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIA----VKEYEWFPESNIGWLQL 438
            ||..:|.|  :.|..:.||.:|..|        |..:|::|..:    :....|..:.
Mouse   854 RLEAILSKAYVYRVIRTTAYLLYSL--------HLNSCLYYWASAFQGIGSTHWVYDG------- 903

  Fly   439 LAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGN 503
                         ...:|....|:...:|.::| |.....|..|.||.::....|....:|:.|.
Mouse   904 -------------VGNSYIRCYYWAVKTLITIG-GLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQ 954

  Fly   504 VTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEE 568
            :..::....:.::.|.|.......::..:.:|:.::.|::.:::.:|.....:|..|.:.:.|::
Mouse   955 MRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDK 1019

  Fly   569 LRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSME 632
            :|.|:::.::..|: ::.:|:...:..:..:...:::....|.:|:..||:....:|.:..|.::
Mouse  1020 MRLDLAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQ 1084

  Fly   633 VI---KDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKC 694
            |:   ....|:..|..|.:.|   .:.|:|...|.              |.::::.|..:.:|..
Mouse  1085 VLGGPDGKAVLVTLKAGSVFG---EISLLAVGGGN--------------RRTANVVAHGFTNLFI 1132

  Fly   695 IHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEG 759
            :....|.|:|..|||.|:......:..|..|.:.
Mouse  1133 LDKKDLNEILVHYPESQKLLRKKARRMLRNNNKP------------------------------- 1166

  Fly   760 GKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSPRNQR------LHQRGRSLITLRETNK 818
             |.||.....||...:|  .:.|:.|.|.     |...||..:      |..|.:.|..|....:
Mouse  1167 -KEEKSVLILPPRAGTP--KLFNAALAAA-----GKMGPRGAKGGKLAHLRARLKELAALEAAAR 1223

  Fly   819 RHRTLNAACSLDRGSFEE-------------PEPLEEEQSSGGKRPSLE 854
            :.:.|..|.|......||             |||.:..:..|...||.:
Mouse  1224 QQQLLEQAKSSQEAGGEEGSGATDQPAPQEPPEPKDPPKPPGPPEPSAQ 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	12/59 (20%)
		PAS_3	41..129	CDD:285623	12/56 (21%)
		Ion_trans	285..516	CDD:278921	56/252 (22%)
		Ion_trans_2	<455..510	CDD:285168	12/54 (22%)
		Crp	583..>650	CDD:223736	11/69 (16%)
		CAP_ED	586..715	CDD:237999	25/131 (19%)
Cngb1	NP_001182342.1	Ion_trans	756..957	CDD:278921	54/236 (23%)
		Crp	1032..>1165	CDD:223736	28/149 (19%)
		CAP_ED	1038..1147	CDD:237999	22/125 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840