DRSC/TRiP Functional Genomics Resources

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Protein Alignment Elk and Cngb1

DIOPT Version :10

Sequence 1:NP_477009.1 Gene:Elk / 37047 FlyBaseID:FBgn0011589 Length:1284 Species:Drosophila melanogaster
Sequence 2:NP_001182342.1 Gene:Cngb1 / 333329 MGIID:2664102 Length:1325 Species:Mus musculus


Alignment Length:894 Identity:169/894 - (18%)
Similarity:325/894 - (36%) Gaps:228/894 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHKDITHTK 136
            |:.|||.:::.|:....:.|.|.|.:..|:||.                      |::..:..||
Mouse   496 PEEKEEKEEEKEEEKEEEEEKKEEEVEKKEEGE----------------------ATNSTVPATK 538

  Fly   137 -MLEMNVNE-------------------------ECDSVFALTAALLGARFRAGSNAGML-GLGG 174
             ..|:.|.:                         :.|::....||..|.|.:..|..... .|..
Mouse   539 EHPELQVEDTDADSGPLIPEETLPPPERPPPSPVKSDTLTVPGAAAAGHRKKLPSQDDEAEELKA 603

  Fly   175 LPGLGGPAASDGD-TEAGEGNNLDVPAGCNMGRRRSRAV---LYQLSGHYKPEKGGVKTKLKLGN 235
            |.....|..:..| |...|.:..|..|  :...:.|..:   |.:|...:|.....||.|| :..
Mouse   604 LSPAESPVVAWSDPTTPQEADGQDRAA--STASQNSAIINDRLQELVKMFKERTEKVKEKL-IDP 665

  Fly   236 NFMHSTEAPFP--------------------------------EYKTQSIKKSRL---ILPHYGV 265
            :.....|:|.|                                ::|.:.:|..|.   |.|...:
Mouse   666 DVTSDEESPKPSPAKKAPEPDPAQKPAEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNL 730

  Fly   266 FKGIWDWVILVATFYVALMVPYNAAF--AKAD--RQTKVSDVIVEALFIVDI-LLNFRTTFVSRK 325
            ...:|.:.:::|..:...::|...||  .:||  ....:.|.:.:.::::|| :...|..|| :.
Mouse   731 MYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHFWLLMDYLCDFIYLLDITVFQMRLQFV-KG 794

  Fly   326 GEVVSNSKQIAINYLRG-WFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLL---------- 379
            |:::::.|::..|||:. .|.:|||..||.|.||   |..|.:.   |::|.|.|          
Mouse   795 GDIITDKKEMRNNYLKSRRFKMDLLCLLPLDFLY---LKLGINP---LLRLPRCLKYMAFFEFNN 853

  Fly   380 RLARLLQK--IDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIA----VKEYEWFPESNIGWLQL 438
            ||..:|.|  :.|..:.||.:|..|        |..:|::|..:    :....|..:.       
Mouse   854 RLEAILSKAYVYRVIRTTAYLLYSL--------HLNSCLYYWASAFQGIGSTHWVYDG------- 903

  Fly   439 LAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGN 503
                         ...:|....|:...:|.::| |.....|..|.||.::....|....:|:.|.
Mouse   904 -------------VGNSYIRCYYWAVKTLITIG-GLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQ 954

  Fly   504 VTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEE 568
            :..::....:.::.|.|.......::..:.:|:.::.|::.:::.:|.....:|..|.:.:.|::
Mouse   955 MRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDK 1019

  Fly   569 LRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSME 632
            :|.|:::.::..|: ::.:|:...:..:..:...:::....|.:|:..||:....:|.:..|.::
Mouse  1020 MRLDLAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQ 1084

  Fly   633 VI---KDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKC 694
            |:   ....|:..|..|.:.|   .:.|:|...|.              |.::::.|..:.:|..
Mouse  1085 VLGGPDGKAVLVTLKAGSVFG---EISLLAVGGGN--------------RRTANVVAHGFTNLFI 1132

  Fly   695 IHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEG 759
            :....|.|:|..|||.|:......:..|..|.:.                               
Mouse  1133 LDKKDLNEILVHYPESQKLLRKKARRMLRNNNKP------------------------------- 1166

  Fly   760 GKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSPRNQR------LHQRGRSLITLRETNK 818
             |.||.....||...:|  .:.|:.|.|.     |...||..:      |..|.:.|..|....:
Mouse  1167 -KEEKSVLILPPRAGTP--KLFNAALAAA-----GKMGPRGAKGGKLAHLRARLKELAALEAAAR 1223

  Fly   819 RHRTLNAACSLDRGSFEE-------------PEPLEEEQSSGGKRPSLE 854
            :.:.|..|.|......||             |||.:..:..|...||.:
Mouse  1224 QQQLLEQAKSSQEAGGEEGSGATDQPAPQEPPEPKDPPKPPGPPEPSAQ 1272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ElkNP_477009.1 PAS_9 40..133 CDD:463873 12/60 (20%)
PLN03192 270..>650 CDD:215625 80/405 (20%)
cNMP 586..716 CDD:197516 25/132 (19%)
Cngb1NP_001182342.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..124
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..198
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..279
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 340..470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..637 30/164 (18%)
Calmodulin-binding CaM1. /evidence=ECO:0000250|UniProtKB:Q28181 633..643 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 659..694 6/35 (17%)
PLN03192 724..>1110 CDD:215625 83/424 (20%)
Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:Q14028 862..961 21/127 (17%)
C-linker. /evidence=ECO:0000250|UniProtKB:Q14028 964..1040 11/75 (15%)
CAP_ED 1038..1147 CDD:237999 22/125 (18%)
cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060 1038..1142 20/120 (17%)
Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:Q14028 1044..1160 24/132 (18%)
Calmodulin-binding CaM2. /evidence=ECO:0000250|UniProtKB:Q28181 1224..1230 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1325 11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

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