DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Hcn4

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001074661.1	Gene:	Hcn4 / 330953	MGIID:	1298209	Length:	1201	Species:	Mus musculus

Alignment Length:	1303	Identity:	277/1303 - (21%)
Similarity:	483/1303 - (37%)	Gaps:	350/1303 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 NVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLG---------GPAASDGDTEAGEGNNL 196
            :.|.:|.. |..:.|.||:|   |..:|  |.||...||         ...|::||...||..
Mouse    88 STNGDCRR-FRGSLASLGSR---GGGSG--GAGGGSSLGHLHDSAEERRLIAAEGDASPGEDR-- 144

  Fly   197 DVPAGCNMGRRRSRAVLYQLSGHYKPE---------------------KGGV--------KTKLK 232
             .|.|......|. |...|.:....|:                     :||.        :.:::
Mouse   145 -TPPGLATEPERP-ATAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEVR 207

  Fly   233 LG-NNFMH--------------------STEAPFPEYKTQSIKKSRLILPH-YGVFKGIWDWVIL 275
            || :.||.                    |.:|  .|.:.:.:|.:...:.| |..|:..||..:|
Mouse   208 LGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKA--VEREQERVKSAGFWIIHPYSDFRFYWDLTML 270

  Fly   276 VATFYVALMVPYNAAFAKADRQTK--VSDVIVEALFIVDILLNFRTTFVSRKG-EVVSNSKQIAI 337
            :......:::|....|.|.:..|.  |.:|:.:..|::|::|||||..|.... |::.:.::|.:
Mouse   271 LLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKM 335

  Fly   338 NYLRGWFALDLLAALPFDHLYA-------SDLYDGEDSHIHLVKLT------RLLRLARLLQKID 389
            .||:.||.:|.::::|.|:::.       |::|....: :.:|:.|      |||||:||::.|.
Mouse   336 KYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKTARA-LRIVRFTKILSLLRLLRLSRLIRYIH 399

  Fly   390 RYSQHTAMILTL---------LMFSFTLAAHWLACIWYVIAVKEYEWFPESNIGWLQLLAERKNA 445
            ::.:...|...|         |:....|..||..|:.:::.:  .:.||..  .|:.:.....|
Mouse   400 QWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPM--LQDFPHD--CWVSINGMVNN- 459

  Fly   446 SVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQR 510
                 :..:.||.||:...:.:..:|:|..:....::...|::.|::||..:|:..|:.||:||.
Mouse   460 -----SWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQS 519

  Fly   511 MYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGD-VS 574
            :.|.|..|:.|::.::.:::.|.:|.:.:|||.||::..:. ....|....|.|..|.||.: ::
Mouse   520 LDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIIN 583

  Fly   575 MHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMV 639
            .:..:.:..:|:|..|....:..:...::.....||:|:|.:|.....:|::.:|         |
Mouse   584 FNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHG---------V 639

  Fly   640 VAILGKGD----LVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGL 700
            |::|.||:    |........:...:.|:.||:               ::|.|||.|..:.:...
Mouse   640 VSVLTKGNKETKLADGSYFGEICLLTRGRRTAS---------------VRADTYCRLYSLSVDNF 689

  Fly   701 VEVLRLYPEYQQQF------------------ANDIQHDLTCNLREGYENQDSDIGPSFPLPSIS 747
            .|||..||..::.|                  .:.:||||...:   :..|:::|     :..|.
Mouse   690 NEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGV---FNYQENEI-----IQQIV 746

  Fly   748 EDDENREEAEEGGKGEKENGGGP--------PSGASPLH------NISNSPLHATRSPLLGMGSP 798
            ..|  ||.|....:.:......|        |...:||.      :::.:..|..|.|......|
Mouse   747 RHD--REMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPP 809

  Fly   799 RNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTL 863
            ....|...|..     :|.:..|.|.:......||           :|....||.....|..|..
Mouse   810 PGPGLGNLGAG-----QTPRHPRRLQSLIPSALGS-----------ASPASSPSQVDTPSSSSFH 858

  Fly   864 HQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGV 928
            .|.:|..||.     ..|..:..:|::.....:...|||.:....:..|.:.:|....|..:||.
Mouse   859 IQQLAGFSAP-----PGLSPLLPSSSSSPPPGACGSPPAPTPSTSTAAAASTTGFGHFHKALGGS 918

  Fly   929 LAAAE---LAAMQ------RSSSHPPEVWGRDVQL---------PTSNTASSKAPSPV-EPKKTM 974
            |::::   |..:|      :::..||.:.|....|         |.|:.:.|.:|..: :|...:
Mouse   919 LSSSDSPLLTPLQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGEL 983

  Fly   975 T-------SRSSQTDFYRIDFPTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLN- 1031
            :       |.:.:|.      |..||     |..:.|..|                  ..||:.
Mouse   984 SLGLAAGPSSTPETP------PRPER-----PSFMAGASG------------------GASPVAF 1019

  Fly  1032 TIDECVSPSDHNLASSKERLITSSAVPTPGRIYPPLDDENSNDFRWTMKHSASHHSCCKSTDALL 1096
            |....:||..|:              |.|.|.:|....          :.|.||.|      .||
Mouse  1020 TPRGGLSPPGHS--------------PGPPRTFPSAPP----------RASGSHGS------LLL 1054

  Fly  1097 SPEEQPPISILP-----VDATPAPSVQEVRSSKRSLRKSTSGSNSSLSSSSSSSNSCLVSQSTGN 1156
            .|...||...:|     ...||....|::        |..|.|..:|...             |.
Mouse  1055 PPASSPPPPQVPQRRGTPPLTPGRLTQDL--------KLISASQPALPQD-------------GA 1098

  Fly  1157 LTTTNASVHCSNSSQSVASVATTRRASWKLQHSRSGEYRRLSEATAEYSPPAKTPLPVAGVSYGG 1221
            .|...||.|  :|.:|||:.:...||.       .|     |.::....||        |..||.
Mouse  1099 QTLRRASPH--SSGESVAAFSLYPRAG-------GG-----SGSSGGLGPP--------GRPYGA 1141

  Fly  1222 DEEESVELLGPRRNSR-----PI-LLGVSQNQGQGQAMNFRFSAGDADKLEKGLRGLPSTRSLRD 1280
            ...:.|.|  ||:.|.     |: |.|.......|..:...     |.:.|.|.|..|....|
Mouse  1142 IPGQHVTL--PRKTSSGSLPPPLSLFGARAASSGGPPLTTA-----APQREPGARSEPVRSKL-- 1197

  Fly  1281 PSS 1283
            ||:
Mouse  1198 PSN 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	63/255 (25%)
		Ion_trans_2	<455..510	CDD:285168	15/54 (28%)
		Crp	583..>650	CDD:223736	16/70 (23%)
		CAP_ED	586..715	CDD:237999	29/150 (19%)
Hcn4	NP_001074661.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..121		13/38 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..183		10/51 (20%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		9/52 (17%)
		Ion_trans_N	218..260	CDD:285597	6/43 (14%)
		Ion_trans	280..525	CDD:278921	63/255 (25%)
		Crp	589..>724	CDD:223736	30/158 (19%)
		CAP_ED	595..703	CDD:237999	28/131 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..902		22/118 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..1201		84/398 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835134
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740