DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and eag

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001036275.1	Gene:	eag / 32428	FlyBaseID:	FBgn0000535	Length:	1270	Species:	Drosophila melanogaster

Alignment Length:	1342	Identity:	402/1342 - (29%)
Similarity:	603/1342 - (44%)	Gaps:	311/1342 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MP-ARKGLLAPQNTFLDTIATRFDG-THSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKG 63
            || .|:||:|||||||:.|..|.:. ..|:|:|.|||....|||||::.|..::||:||::|||.
  Fly     1 MPGGRRGLVAPQNTFLENIIRRSNSQPDSSFLLANAQIVDFPIVYCNESFCKISGYNRAEVMQKS 65

  Fly    64 CS--CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKK-----------------EGAPFWCL 109
            |.  |.|:||..|.:|...::|.:|.|:.:.:.|::.|||                 :..|.|.|
  Fly    66 CRYVCGFMYGELTDKETVGRLEYTLENQQQDQFEILLYKKNNLQCGCALSQFGKAQTQETPLWLL 130

  Fly   110 FDIVPIKNEKRDVVLFLASHKDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGG 174
            ..:.||:||:..|||||.:.:|||   .|:..::.|                   ...|:|||..
  Fly   131 LQVAPIRNERDLVVLFLLTFRDIT---ALKQPIDSE-------------------DTKGVLGLSK 173

  Fly   175 LPGLGGPAASDGDTEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMH 239
            ...|.....                        |||    |.|.|....|...|.     :|..|
  Fly   174 FAKLARSVT------------------------RSR----QFSAHLPTLKDPTKQ-----SNLAH 205

  Fly   240 --STEAP-FPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAF---AKADRQT 298
              |..|. .|:|:.::.|....||.||..||.|||||||..|||.|:|||||.||   ...|...
  Fly   206 MMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWVILCLTFYTAIMVPYNVAFKNKTSEDVSL 270

  Fly   299 KVSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDL- 362
            .|.|.||:.:|.:||:|||.||||...|||||:.|.|.:|||:.||.:|||:.||:|...|.|.
  Fly   271 LVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLLSCLPYDVFNAFDRD 335

  Fly   363 YDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEW 427
            .||..|....:|:.|||||.|:::|:|||.::.|.:|.||:..:.|.|||||||||.|...:
  Fly   336 EDGIGSLFSALKVVRLLRLGRVVRKLDRYLEYGAAMLILLLCFYMLVAHWLACIWYSIGRSD--- 397

  Fly   428 FPESNI--GWLQLLAERKNASVAILTTAET-------------YSTALYFTFTSLTSVGFGNVSA 477
             .::.|  .||..||....:..:.:.:.:|             |.||||||.|.:||||||||:|
  Fly   398 -ADNGIQYSWLWKLANVTQSPYSYIWSNDTGPELVNGPSRKSMYVTALYFTMTCMTSVGFGNVAA 461

  Fly   478 NTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRI 542
            .|..||||||.||:|.||::|.:||:||.|||:|.|..:.|.....::::|:.||.:||.|.:|:
  Fly   462 ETDNEKVFTICMMIIAALLYATIFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERV 526

  Fly   543 EDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNF 606
            .||..::|:::.|:|..:.|...|::::.|:.:||:|::. :.|.|..||.|||:.|::|...:.
  Fly   527 MDYVVSTWAMTKGLDTEKVLNYCPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFMMSH 591

  Fly   607 CAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNS 671
            .|||:.|.|.|::::.:.::..||:|||:||.|||||||||:.|...              ..:|
  Fly   592 SAPGDLLYHTGESIDSLCFIVTGSLEVIQDDEVVAILGKGDVFGDQF--------------WKDS 642

  Fly   672 AGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGY------ 730
            |    |.:|:::::|||||||..|....|:|||..|..:...||.::.  ||.|||...
  Fly   643 A----VGQSAANVRALTYCDLHAIKRDKLLEVLDFYSAFANSFARNLV--LTYNLRHRLIFRKVA 701

  Fly   731 -------------------ENQDSDIGPSFP----LPSISEDDENREEAEEGGKGEKENGGGP-- 770
                               :|||..:...|.    .|.:...  ::|.....|:.:.|.|.|.
  Fly   702 DVKREKELAERRKNEPQLPQNQDHLVRKIFSKFRRTPQVQAG--SKELVGGSGQSDVEKGDGEVE 764

  Fly   771 -----------------PSGASPLHNISNSPLHATRSPLLGMGSPRNQRLHQRGR-----SLITL 813
                             .:.|:|    |.||   :.||..|..|.|:.|..:.||     |:.:.
  Fly   765 RTKLPAKLTLTEDARILSTAAAP----SPSP---SPSPSSGPPSARSTRASKWGRLLGSSSVDSA 822

  Fly   814 RETNKR---HRTLNAACSLDRGSFEEPEPLEEEQSSGG-------KRPSLERLDSQVSTLHQDVA 868
            .:|:.:   .|:|:|..|| |.|..:........|:||       |.|.|:.  ||.:...||..
  Fly   823 SDTSAKVAVSRSLSARESL-RESTAQARQSSTSSSNGGQGNKVFPKAPKLQA--SQATLARQDTI 884

  Fly   869 QLSAEVRNAISALQEMTFTSNAMTSHSSL-KFPPARSIPNISGVAGTRSGVAVEHGLMGGVLAAA 932
            ....||.::..:.........|..|.::: ..||..:..:.:..||...|    .|..|.|:|..
  Fly   885 DEGGEVDSSPPSRDSRVVIEGAAVSSATVGPSPPVATTSSAAAGAGVSGG----PGSGGTVVAIV 945

  Fly   933 ELA----AMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFY----RIDFP 989
            ..|    |::|.         |.:::                   .:||::.:|.|    |...|
  Fly   946 TKADRNLALERE---------RQIEM-------------------ASSRATTSDTYDTGLRETPP 982

  Fly   990 TFERFVLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDHNLA----SSKER 1050
            |     ||...|:..:|.::..::.|:..:||:       :..|::.:......||    |....
  Fly   983 T-----LAQRDLIATVLDMKVDVRLELQRMQQR-------IGRIEDLLGELVKRLAPGAGSGGNA 1035

  Fly  1051 LITSSAVPTPGRIYPPLDDENSNDFRWTMKHSASHHSC--CKSTDALLSPEEQPPISIL--PVDA 1111
            ...||...|||       ||                .|  |.:........:.||.|.:  |||.
  Fly  1036 PDNSSGQTTPG-------DE----------------ICAGCGAGGGGTPTTQAPPTSAVTSPVDT 1077

  Fly  1112 TPAPSVQEVRSSKRSLRKSTSGSNSSLSSSSSSSNSCLVSQSTGNLTTTNASVHCSNSSQSVASV 1176
            .              :..|:.|::.|.|.:.:.:.|.:.......|....|:|..|.....:..:
  Fly  1078 V--------------ITISSPGASGSGSGTGAGAGSAVAGAGGAGLLNPGATVVSSAGGNGLGPL 1128

  Fly  1177 ATTRRASWKLQHSRSGEYRRLSEATAEYSPPAKTPLPVAGVS 1218
            ...:|.|    .||...           :||.:|....||.:
  Fly  1129 MLKKRRS----KSRKAP-----------APPKQTLASTAGTA 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	39/114 (34%)
		PAS_3	41..129	CDD:285623	38/106 (36%)
		Ion_trans	285..516	CDD:278921	115/249 (46%)
		Ion_trans_2	<455..510	CDD:285168	37/67 (55%)
		Crp	583..>650	CDD:223736	31/66 (47%)
		CAP_ED	586..715	CDD:237999	48/128 (38%)
eag	NP_001036275.1	PAS_9	28..155	CDD:290162	48/129 (37%)
		PAS	40..153	CDD:238075	39/112 (35%)
		Ion_trans	254..499	CDD:278921	115/248 (46%)
		Ion_trans_2	<440..494	CDD:285168	36/53 (68%)
		Crp	565..>702	CDD:223736	56/156 (36%)
		CAP_ED	571..682	CDD:237999	48/128 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445382
Domainoid	1	1.000	111	1.000	Domainoid score	I2073
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15760at6656
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		mtm8395
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10217
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
	8	7.950