Protein Alignment Elk and Kcnh8

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_659563.1
• Gene: Kcnh8 / 246325
• RGDID: 2549
• Length: 1102
• Species: Rattus norvegicus
• Alignment Length: 1237
• Identity: 506/1237 - (40%)
• Similarity: 673/1237 - (54%)
• Gaps: 252/1237 - (20%)

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||||||||||||:|.||| |.|.|||||||||.:|.|::|.::|||.|
  Rat     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            ||.||:|.:|.|:...||||||..|:|.|.|::||||.|||||||.|||||||||.||||||||.
  Rat    66 SCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            ||||.||:...:.:::.|..        ..|.||||:
  Rat   131 KDITDTKVKITSEDKKEDRA--------KGRSRAGSH---------------------------- 159

  Fly   195 NLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLI 259
                   .:..|||||||||.:|||.:..:   |.|||:.||......| |||||....|||:.|
  Rat   160 -------FDSARRRSRAVLYHISGHLQRRE---KNKLKINNNVFVDKPA-FPEYKVSDAKKSKFI 213

  Fly   260 LPHYGVFKGIWDWVILVATFYVALMVPYNAAF-----AKADRQTKVSDVIVEALFIVDILLNFRT 319
            |.|:..||..|||:||:||||||:.||||..|     ....|.|.|||:.||.|||:||:|||||
  Rat   214 LLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRT 278

  Fly   320 TFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARL 384
            |:||:.|:|:..::.|.|:|:..||.:||:||||||.|||.::  ...|.:||:|..|||||.||
  Rat   279 TYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNV--TVVSLVHLLKTVRLLRLLRL 341

  Fly   385 LQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWLQLLAER- 442
            |||:||||||:.::|||||..|.|.|||:|||||||...|.|      |    .:|||..|.:|
  Rat   342 LQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKW----EVGWLHELGKRL 402

  Fly   443 -----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFG 502
                 .|.::...:....|..|||||.:||||||||||||||.|||:|:|..|||||||||:|||
  Rat   403 ESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFG 467

  Fly   503 NVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPE 567
            ||||||||||||.|||.::.:|||||:.:|::|::||||:.:||||:||:::|||..|.|::||:
  Rat   468 NVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPD 532

  Fly   568 ELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSME 632
            |||.|::|||::|||||.:||.||:|||:.|||||||:||||||||:.:||||..||::|:||||
  Rat   533 ELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSME 597

  Fly   633 VIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHM 697
            |:||.||:||||||||:|:::::                  :|.|:::::|:||||||||:||.:
  Rat   598 VLKDSMVLAILGKGDLIGANLSI------------------KDQVIKTNADVKALTYCDLQCIIL 644

  Fly   698 GGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYE-------NQDSDIGPSFP---------LPSI 746
            .||.|||.|||||..:|..|||||||.|||||:|       :..|.:..:.|         ||||
  Rat   645 KGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKKRLPSI 709

  Fly   747 SEDDENREEAEE-------------GGKGEKENGGGP----------PSGASPLH-----NISNS 783
            .||:|..|..||             .....|:.|...          .||..|.|     :.:||
  Rat   710 VEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANS 774

  Fly   784 PL---------HATRS------PLLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGS 833
            |.         |.||.      .|..:|:.....|..  |.:..:.:.|....|.    :.|.||
  Rat   775 PKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSP--RIVDGIEDGNSSEETQ----TFDFGS 833

  Fly   834 FE-EPEP-----LEEEQSSGG--------KRPSLERLDSQVSTLHQDVAQLSAEVR-------NA 877
            .: .|||     |.|.:....        .:..:.:|:|:|:||.|:|:||..::|       |.
  Rat   834 EQIRPEPRISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENI 898

  Fly   878 ISALQEMTFTSNAMTSHSSLKFPPARSI--PNISGVAG------TRSGVAVEHGLMGGVLAAAEL 934
            :|..|...|.|...||     ..|:|..  ..:|..|.      ..:|..:.||
  Rat   899 LSPQQPSQFCSLHPTS-----ICPSRESFQTRVSWSAHQPCLHLQANGAHLYHG----------- 947

  Fly   935 AAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRIDFPTFERFVLANP 999
                   :...::|..|..|..||           |::|.....|..|......|.
  Rat   948 -------NVTSDIWSVDPSLVGSN-----------PQRTEAHEQSPVDSELHHSPN--------- 985

  Fly  1000 RLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSP-SD------HNLASSKERLITSSAV 1057
                  |...|:         ..|.:|...|..: .|:|| ||      .:::::....:.||:.
  Rat   986 ------LAYSPS---------HCQVIQEGHLQFL-RCISPHSDTTLTPLQSISATLSSSVCSSSE 1034

  Fly  1058 PTPGRIYPPLDDENSNDFRWTMKHSASHHSCCKSTDALLSPEEQPPISILPVDATPAPSVQEVRS 1122
            .:...:.|...:|.|.........|..:.......:.::|...: |:...||:.  ..|..:|:.
  Rat  1035 TSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTE-PLENFPVEV--VTSTADVKD 1096

  Fly  1123 SK 1124
            ||
  Rat  1097 SK 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	63/92 (68%)
		PLN03192	270..>650	CDD:215625	234/396 (59%)
		cNMP	586..716	CDD:197516	71/129 (55%)
Kcnh8	NP_659563.1	PAS_9	40..135	CDD:463873	64/94 (68%)
		PLN03192	175..>615	CDD:215625	257/449 (57%)
		Selectivity filter. /evidence=ECO:0000250	434..439		4/4 (100%)
		cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060	551..668		74/134 (55%)
		PRK11753	578..>656	CDD:236969	46/95 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	683..744		13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	762..793		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..845		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	960..983		7/33 (21%)