DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh5

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_766393.2	Gene:	Kcnh5 / 238271	MGIID:	3584508	Length:	988	Species:	Mus musculus

Alignment Length:	1079	Identity:	336/1079 - (31%)
Similarity:	527/1079 - (48%)	Gaps:	179/1079 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MP-ARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            || .::||:|||||||:.|..|  .:.|:|:|||||....|:||.:|||..|:||.||.:|||..
Mouse     1 MPGGKRGLVAPQNTFLENIVRR--SSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSS 63

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            :|.|:||..|.::..:::.::..|......||:.|||...|.|....|.||:||...|||||.:.
Mouse    64 TCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTF 128

  Fly   130 KDITHTKM-LEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEG 193
            ||||..|. :|.:..:.......||.||
Mouse   129 KDITLFKQPIEDDSTKGWTKFARLTRAL------------------------------------- 156

  Fly   194 NNLDVPAGCNMGRRRSRAVLYQLSGHYKPE----KGGVKTKLKLGNNFMHSTEAPFPEYKTQSIK 254
                         ..||:||.||:...|.|    ...:...|:||::.:       |:||.::.|
Mouse   157 -------------TNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGSDIL-------PQYKQEAPK 201

  Fly   255 KSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK-------VSDVIVEALFIVD 312
            ....|:.||..||..||||||:.|||.|:|||||.:|     :||       |.|.:|:.:|:||
Mouse   202 TPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF-----KTKQNNIAWLVLDSVVDVIFLVD 261

  Fly   313 ILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYD-GEDSHIHLVKLT 376
            |:|||.||||...|||:|:.|.|.:|||:.||.:|||:.||:|.:.|.:..| |..|....:|:.
Mouse   262 IVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVV 326

  Fly   377 RLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFPE-SNI----GWL 436
            |||||.|:.:|:|.|.::.|.:|.||:..|.|.|||||||||  ::.:||...| :|.    .||
Mouse   327 RLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWY--SIGDYEVIDEVTNTIQIDSWL 389

  Fly   437 QLLA------ERKNASVAIL----TTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMML 491
            ..||      .|.|.|..|.    :....|.::||||.||||::||||::..|..||:|::.||:
Mouse   390 YQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 454

  Fly   492 IGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGI 556
            :|:|::|.:|||||.|.|:||:..:.|.....:::||:.|:.:||.|.:|:.||..::||:|.||
Mouse   455 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGI 519

  Fly   557 DIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDAL 620
            |..:.|...|:::|.|:.:||:|::. :.|.|..||.|||:.|::..:|..||||:.:.|.|:::
Mouse   520 DTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESV 584

  Fly   621 NYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIK 685
            :.:.::.:||:|||:|:.|||||||||:.| ||          ....||       :..:.::::
Mouse   585 DALCFVVSGSLEVIQDEEVVAILGKGDVFG-DI----------FWKETT-------LAHACANVR 631

  Fly   686 ALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLR---------------EGYENQDS 735
            |||||||..|....|::||..|..:...|:.::  .||||||               |....|.:
Mouse   632 ALTYCDLHIIKREALLKVLDFYTAFANSFSRNL--TLTCNLRKRIIFRKISDVKKEEEERLRQKN 694

  Fly   736 DIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSPRN 800
            ::..|.|:      |....:..:..|.:||           |....::.....||.|.....|..
Mouse   695 EVTLSIPV------DHPVRKLFQKFKQQKE-----------LRIQGSAQSDPERSQLQVESRPLQ 742

  Fly   801 QRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTLHQ 865
            ......|.|::|:.:......:| |.........:......|.:.:||..|...:::|.: .:..
Mouse   743 NGASITGTSVVTVSQITPIQTSL-AYVKTSESLKQNNRDAMELKPNGGAEPKCLKVNSPI-RMKN 805

  Fly   866 DVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGVLA 930
            ...:....::|.:.|.:|.....|.:|...|:..           ::....|...|:.:....|
Mouse   806 GNGKGWLRLKNNMGAQEEKKEDWNNVTKAESMGL-----------LSEDPKGSDSENSVTKNPL- 858

  Fly   931 AAELAAMQRSSSHPPEVWGRDVQLPTSNTASS---KAPSPVEPKKT---MTSRSSQTDFYRIDFP 989
                   :::.|....:...|::|..:..|.|   .:||..:.|.:   :..::.||....:...
Mouse   859 -------RKTDSCDSGITKSDLRLDKAGEARSPLEHSPSQADVKHSFYPIPEQALQTTLQEVKHE 916

  Fly   990 TFERFVLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQIS 1028
            ..|...|.:.|:.    .:|..:...:.||.:|...|.|
Mouse   917 LKEDIQLLSCRMT----ALEKQVAEILKLLSEKSVPQTS 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	38/95 (40%)
		PAS_3	41..129	CDD:285623	36/87 (41%)
		Ion_trans	285..516	CDD:278921	110/253 (43%)
		Ion_trans_2	<455..510	CDD:285168	28/54 (52%)
		Crp	583..>650	CDD:223736	30/66 (45%)
		CAP_ED	586..715	CDD:237999	46/128 (36%)
Kcnh5	NP_766393.2	PAS	37..131	CDD:238075	38/93 (41%)
		PAS_3	40..127	CDD:285623	36/86 (42%)
		Ion_trans	232..479	CDD:278921	110/253 (43%)
		Ion_trans_2	<419..473	CDD:285168	28/53 (53%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	544..723	CDD:223736	63/215 (29%)
		CAP_ED	550..660	CDD:237999	46/127 (36%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..741		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	838..893		10/73 (14%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		7/42 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840