Protein Alignment Elk and KCNH3

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_011536387.1
• Gene: KCNH3 / 23416
• HGNCID: 6252
• Length: 1094
• Species: Homo sapiens
• Alignment Length: 1129
• Identity: 451/1129 - (39%)
• Similarity: 589/1129 - (52%)
• Gaps: 259/1129 - (22%)

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANG-NPIVYCSDGFVDLTGYSRAQIMQKGC 64
            |||.:||||||||||||||||||||||||||||||..| .|:|||||||.||||:|||::||:||
Human     1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            :|.|||||||.|..:|||.|:|....|.|.|:|.|:|.|.|||||.|::||||||.:|.|||.||
Human    66 ACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSH 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            |||:.||                                        ..|||   |...|.|.|.
Human   131 KDISETK----------------------------------------NRGGP---DRWKETGGGR 152

  Fly   195 NLDVPA---GCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKS 256
            .....|   |.|..|||||||||.||||.:.:..| |.||..|   :...:...||||..:|:||
Human   153 RRYGRARSKGFNANRRRSRAVLYHLSGHLQKQPKG-KHKLNKG---VFGEKPNLPEYKVAAIRKS 213

  Fly   257 RLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQT------KVSDVIVEALFIVDILL 315
            ..||.|.|..:..||..||:||.|||:.|||:...:.|...:      .|.|:.||.|||:||:|
Human   214 PFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVL 278

  Fly   316 NFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFD--HLYASDLYDGEDSHIHLVKLTRL 378
            ||||||||:.|:||...|.|.::|:..||.||::||||||  |.:..::|.|    .||:|..||
Human   279 NFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYFG----AHLLKTVRL 339

  Fly   379 LRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE----WFPESNIGWLQLL 439
            |||.|||.::|||||::|::|||||..|.|.|||:||:|:.|..:|.|    ..||  |||||.|
Human   340 LRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESELPE--IGWLQEL 402

  Fly   440 AER------------------------KNASVAILTTAE---------TYSTALYFTFTSLTSVG 471
            |.|                        .::|.|..|..|         .|.|:|||..:||||||
Human   403 ARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVG 467

  Fly   472 FGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPK 536
            ||||||||..||:|:|..|||||||||||||||||||||||:||.||.|:.|||:|::.:|.:||
Human   468 FGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPK 532

  Fly   537 ELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREILQLPIFEAASQGCLKLLSLH 601
            .||||:.:|||.:|::::|||..|.|:..|:|||.|::||||:|:||||:|||||:|||:.|||.
Human   533 PLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLA 597

  Fly   602 IKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMT 666
            ::..||.|||||||:||||..:|::|:|||||:|...|:||||||||:|.::
Human   598 LRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCEL------------- 649

  Fly   667 ATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYE 731
                 ..::.||::::|:|.||||.|:|:.:.||.:.|.||||:..:|:..::.:|:.||..|..
Human   650 -----PRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGG 709

  Fly   732 NQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGG--GPPSGASPLHNISNSPLHATRSPLLG 794
            :.:.|..      |:|.|:......|     |||..|  ||        .:|.:|.....||||.
Human   710 SAEVDTS------SLSGDNTLMSTLE-----EKETDGEQGP--------TVSPAPADEPSSPLLS 755

  Fly   795 MG-----------SPR----NQRLHQRG------------------RSLITLR--------ETNK 818
            .|           |||    ..||..||                  |:|..||        ..:.
Human   756 PGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDL 820

  Fly   819 RHRTLNA---ACSLDRGSF------EEPE------------------PLEEEQSSGGKRPSLERL 856
            ..|.::.   .|..|:..|      ..||                  |.|....:....||..|.
Human   821 SPRVVDGIEDGCGSDQPKFSFRVGQSGPECSSSPSPGPAPADNPILLPTESGLLTVPHGPSEARN 885

  Fly   857 DSQVSTLHQDVAQLSAEV---RNAISALQEMTFTSNAMTSHSSLKFPPARS--IPNISG------ 910
            ...:..|.|.|.:||.:|   |..:.:|::..          .|...|.|.  .|..||
Human   886 TDTLDKLRQAVTELSEQVLQMREGLQSLRQAV----------QLVLAPHREGPCPRASGEGPCPA 940

  Fly   911 -VAGTRSGVAVEHGLMGGVLAAAELAAMQRSSSHP---------PEVWG---------------- 949
             .:|....:.|:.|.....|.....:.:..:..||         |..||
Human   941 STSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFW 1005

  Fly   950 ---RDVQLPTSNTASSKAPSPVEP 970
               .|.:.|.|....|:..:|..|
Human  1006 TSTSDSEPPASGDLCSEPSTPASP 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	60/92 (65%)
		PLN03192	270..>650	CDD:215625	223/424 (53%)
		cNMP	586..716	CDD:197516	60/129 (47%)
KCNH3	XP_011536387.1	PAS_9	40..135	CDD:463873	61/94 (65%)
		PLN03192	227..>646	CDD:215625	223/424 (53%)
		cyc_nuc_ocin	<606..701	CDD:274839	46/112 (41%)