Protein Alignment Elk and KCNH4

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_036417.1
• Gene: KCNH4 / 23415
• HGNCID: 6253
• Length: 1017
• Species: Homo sapiens
• Alignment Length: 1087
• Identity: 474/1087 - (43%)
• Similarity: 620/1087 - (57%)
• Gaps: 183/1087 - (16%)

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||||||||||||:|.||| ..|.|||||||||.:||||.|.::|||.|
Human     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            ||.|||||:|.|...|::.|:|....|.:.|:.||:|:|:.||||.|::|||||..:|||||.|.
Human    66 SCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            ||||.:                                      |.||| ||....||  :...|
Human   131 KDITQS--------------------------------------GSPGL-GPQGGRGD--SNHEN 154

  Fly   195 NLDVPAGC---NMGRRRSRAVLYQLSGHY-KPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKK 255
            :|......   ...|||||.||::|:||: :..:||:|     .||.:...:...||||..|:..
Human   155 SLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMK-----ANNNVFEPKPSVPEYKVASVGG 214

  Fly   256 SRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD------RQTKVSDVIVEALFIVDIL 314
            ||.:|.||.|.|.|||.:||:||||||:.||||..|:..|      |.|.|||:.||.|||:||:
Human   215 SRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDII 279

  Fly   315 LNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLL 379
            ||||||:||:.|:|:|..:.|.::||..||.:||:||||||.||..::  ...|.:||:|..|||
Human   280 LNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNI--TVTSLVHLLKTVRLL 342

  Fly   380 RLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWLQL 438
            ||.|||||::||||.:|::|||||..|.|.|||:|||||||..:|.|      |    :||||..
Human   343 RLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLW----DIGWLHE 403

  Fly   439 LAER-----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHA 498
            |.:|     .|.||...:....|..|||||.:||||||||||.|||.|||:|:|..|||||||||
Human   404 LGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHA 468

  Fly   499 VVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLR 563
            ||||||||||||||||||||.|:.:|||||:.:|.:|:.||||:.:||||:|:::.|||..|.||
Human   469 VVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLR 533

  Fly   564 EFPEELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCN 628
            :||:|||.|::|||:|||||||:|.|||:|||:.|||||||:||||||||:.:||||...||:|:
Human   534 DFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCS 598

  Fly   629 GSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLK 693
            ||:||::|:||:||||||||:|:||      ...||....  .|..:.|:::|:|:||||||.|:
Human   599 GSLEVLRDNMVLAILGKGDLIGADI------PEPGQEPGL--GADPNFVLKTSADVKALTYCGLQ 655

  Fly   694 CIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYEN---------------QDSDIGPSF-- 741
            .:...||.|||||||||...|...:..|||.|||:|.:.               :...:|.|.
Human   656 QLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK 720

  Fly   742 PLPSISEDDENREEAEEGGKGEKENGGGP---------------PSGA---------SPLHNISN 782
            .||||:       |||.|.    |.||||               |.|:         .|...:.:
Human   721 TLPSIT-------EAESGA----EPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVS 774

  Fly   783 SP-LHATRSPLLG--------MGSPRNQRLHQRGRSLI----TLRETNKRHRTL----NAACSLD 830
            || |..:.||.|.        .|.||.....:..:.||    |....:...|.:    ::..:.:
Human   775 SPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAE 839

  Fly   831 RGSF------EEPEPLEEEQSSGGKRPSLE-------------RLDSQVSTLHQDVAQLSAEVRN 876
            ..||      |.|.|..:...: |.|||.|             ||:.::|.|:|:|:|||.|:|:
Human   840 APSFRFSRRPELPRPRSQAPPT-GTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRH 903

  Fly   877 AISALQEMTFTSNAMTSHSSLKFPPARSI--PNISGVAGTRSGVAVEHGLMGGVLAAAELAAMQ- 938
            .:..||............:....||...:  |.:|..| :|...:::...:..|...|.:..|:
Human   904 IMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCA-SRPPPSLQDTTLAEVHCPASVGTMET 967

  Fly   939 -------RSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRS 978
                   |.|..||.....| .|..|....:..|:|...:.:..|||
Human   968 GTALLDLRPSILPPYPSEPD-PLGPSPVPEASPPTPSLLRHSFQSRS 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	54/92 (59%)
		PLN03192	270..>650	CDD:215625	238/396 (60%)
		cNMP	586..716	CDD:197516	72/129 (56%)
KCNH4	NP_036417.1	PRK13559	41..>179	CDD:237427	73/178 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..157		8/21 (38%)
		PLN03192	177..>620	CDD:215625	259/453 (57%)
		Selectivity filter. /evidence=ECO:0000250	439..444		4/4 (100%)
		cNMP-binding domain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00060	556..620		44/63 (70%)
		cNMP_binding	578..667	CDD:459637	48/96 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..749		16/68 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..803		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..875		11/54 (20%)
		PHA02682	838..>999	CDD:177464	39/163 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..1017		12/44 (27%)