DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and KCNH4

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_036417.1	Gene:	KCNH4 / 23415	HGNCID:	6253	Length:	1017	Species:	Homo sapiens

Alignment Length:	1087	Identity:	474/1087 - (43%)
Similarity:	620/1087 - (57%)	Gaps:	183/1087 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||||||||||||:|.||| ..|.|||||||||.:||||.|.::|||.|
Human     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            ||.|||||:|.|...|::.|:|....|.:.|:.||:|:|:.||||.|::|||||..:|||||.|.
Human    66 SCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            ||||.:                                      |.||| ||....||  :...|
Human   131 KDITQS--------------------------------------GSPGL-GPQGGRGD--SNHEN 154

  Fly   195 NLDVPAGC---NMGRRRSRAVLYQLSGHY-KPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKK 255
            :|......   ...|||||.||::|:||: :..:||:|     .||.:...:...||||..|:..
Human   155 SLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMK-----ANNNVFEPKPSVPEYKVASVGG 214

  Fly   256 SRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD------RQTKVSDVIVEALFIVDIL 314
            ||.:|.||.|.|.|||.:||:||||||:.||||..|:..|      |.|.|||:.||.|||:||:
Human   215 SRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDII 279

  Fly   315 LNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLL 379
            ||||||:||:.|:|:|..:.|.::||..||.:||:||||||.||..::  ...|.:||:|..|||
Human   280 LNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNI--TVTSLVHLLKTVRLL 342

  Fly   380 RLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWLQL 438
            ||.|||||::||||.:|::|||||..|.|.|||:|||||||..:|.|      |    :||||..
Human   343 RLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLW----DIGWLHE 403

  Fly   439 LAER-----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHA 498
            |.:|     .|.||...:....|..|||||.:||||||||||.|||.|||:|:|..|||||||||
Human   404 LGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHA 468

  Fly   499 VVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLR 563
            ||||||||||||||||||||.|:.:|||||:.:|.:|:.||||:.:||||:|:::.|||..|.||
Human   469 VVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLR 533

  Fly   564 EFPEELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCN 628
            :||:|||.|::|||:|||||||:|.|||:|||:.|||||||:||||||||:.:||||...||:|:
Human   534 DFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCS 598

  Fly   629 GSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLK 693
            ||:||::|:||:||||||||:|:||      ...||....  .|..:.|:::|:|:||||||.|:
Human   599 GSLEVLRDNMVLAILGKGDLIGADI------PEPGQEPGL--GADPNFVLKTSADVKALTYCGLQ 655

  Fly   694 CIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYEN---------------QDSDIGPSF-- 741
            .:...||.|||||||||...|...:..|||.|||:|.:.               :...:|.|.
Human   656 QLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK 720

  Fly   742 PLPSISEDDENREEAEEGGKGEKENGGGP---------------PSGA---------SPLHNISN 782
            .||||:       |||.|.    |.||||               |.|:         .|...:.:
Human   721 TLPSIT-------EAESGA----EPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVS 774

  Fly   783 SP-LHATRSPLLG--------MGSPRNQRLHQRGRSLI----TLRETNKRHRTL----NAACSLD 830
            || |..:.||.|.        .|.||.....:..:.||    |....:...|.:    ::..:.:
Human   775 SPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAE 839

  Fly   831 RGSF------EEPEPLEEEQSSGGKRPSLE-------------RLDSQVSTLHQDVAQLSAEVRN 876
            ..||      |.|.|..:...: |.|||.|             ||:.::|.|:|:|:|||.|:|:
Human   840 APSFRFSRRPELPRPRSQAPPT-GTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRH 903

  Fly   877 AISALQEMTFTSNAMTSHSSLKFPPARSI--PNISGVAGTRSGVAVEHGLMGGVLAAAELAAMQ- 938
            .:..||............:....||...:  |.:|..| :|...:::...:..|...|.:..|:
Human   904 IMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCA-SRPPPSLQDTTLAEVHCPASVGTMET 967

  Fly   939 -------RSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRS 978
                   |.|..||.....| .|..|....:..|:|...:.:..|||
Human   968 GTALLDLRPSILPPYPSEPD-PLGPSPVPEASPPTPSLLRHSFQSRS 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	54/95 (57%)
		PAS_3	41..129	CDD:285623	50/87 (57%)
		Ion_trans	285..516	CDD:278921	141/247 (57%)
		Ion_trans_2	<455..510	CDD:285168	43/54 (80%)
		Crp	583..>650	CDD:223736	47/66 (71%)
		CAP_ED	586..715	CDD:237999	71/128 (55%)
KCNH4	NP_036417.1	PAS_9	29..135	CDD:290162	61/105 (58%)
		PAS	29..133	CDD:238075	59/103 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..157		8/21 (38%)
		Ion_trans	244..486	CDD:278921	141/247 (57%)
		Ion_trans_2	<426..480	CDD:285168	43/53 (81%)
		Selectivity filter. /evidence=ECO:0000250	439..444		4/4 (100%)
		CAP_ED	556..676	CDD:237999	71/127 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..749		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..803		9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..875		11/54 (20%)
		PHA02682	838..>999	CDD:177464	39/163 (24%)
		bZIP	<872..901	CDD:304365	9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..1017		12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145050
Domainoid	1	1.000	279	1.000	Domainoid score	I1701
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	792	1.000	Inparanoid score	I517
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm40327
orthoMCL	1	0.900	-	-		OOG6_104228
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760