Protein Alignment Elk and Kcnh8

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_036016335.1
• Gene: Kcnh8 / 211468
• MGIID: 2445160
• Length: 1103
• Species: Mus musculus
• Alignment Length: 1334
• Identity: 518/1334 - (38%)
• Similarity: 692/1334 - (51%)
• Gaps: 344/1334 - (25%)

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||||||||||||:|.||| |.|.|||||||||.:|.|::|.::|||.|
Mouse     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            ||.||:|.:|.|:...||||||..|:|.|.|::||||.|||||||.|||||||||.||||||||.
Mouse    66 SCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            ||||.||:...:.:::.|..        ..|.||||:
Mouse   131 KDITDTKVKITSEDKKEDRT--------KGRSRAGSH---------------------------- 159

  Fly   195 NLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLI 259
                   .:..|||||||||.:|||.:..:   |.|||:.||......| |||||....|||:.|
Mouse   160 -------FDSARRRSRAVLYHISGHLQRRE---KNKLKINNNVFVDKPA-FPEYKVSDAKKSKFI 213

  Fly   260 LPHYGVFKGIWDWVILVATFYVALMVPYNAAF-----AKADRQTKVSDVIVEALFIV-DILLNFR 318
            |.|:..||..|||:||:||||||:.||||..|     ....|.|.|||:.||.|||: ||:||||
Mouse   214 LLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIADIILNFR 278

  Fly   319 TTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLAR 383
            ||:||:.|:|:..::.|.|:|:..||.:||:||||||.|||.::  ...|.:||:|..|||||.|
Mouse   279 TTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNV--TVVSLVHLLKTVRLLRLLR 341

  Fly   384 LLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWLQLLAER 442
            ||||:||||||:.::|||||..|.|.|||:|||||||...|.|      |    .:|||..|.:|
Mouse   342 LLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKW----EVGWLHELGKR 402

  Fly   443 ------KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVF 501
                  .|.::...:....|..|||||.:||||||||||||||.|||:|:|..|||||||||:||
Mouse   403 LESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVF 467

  Fly   502 GNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFP 566
            |||||||||||||.|||.::.:|||||:.:|::|::||||:.:||||:||:::|||..|.|::||
Mouse   468 GNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFP 532

  Fly   567 EELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSM 631
            :|||.|::|||::|||||.:||.||:|||:.|||||||:||||||||:.:||||..||::|:|||
Mouse   533 DELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSM 597

  Fly   632 EVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIH 696
            ||:||.||:||||||||:|:::::                  :|.|:::::|:||||||||:||.
Mouse   598 EVLKDSMVLAILGKGDLIGANLSI------------------KDQVIKTNADVKALTYCDLQCII 644

  Fly   697 MGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYE-------NQDSDIGPSFP---------LPS 745
            :.||.|||.|||||..:|..|||||||.|||||:|       :..|.:..:.|         |||
Mouse   645 LKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVSQAEPKGNGSINKRLPS 709

  Fly   746 ISEDDENREEAEE-------------GGKGEKENGGGP----------PSGASPLH-----NISN 782
            |.||:|..|..||             .....|:.|...          .||..|.|     :.:|
Mouse   710 IVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSNKTYLGLSLKQLASGTVPFHSPIRVSSAN 774

  Fly   783 SPL---------HATRS------PLLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRG 832
            ||.         |..:.      .|..:||.....|..|....|....:|:..:|      .|.|
Mouse   775 SPKTKQEADPPNHGRKKEKNLKVQLSSLGSAGTPELSPRIVDGIEDGNSNEETQT------FDFG 833

  Fly   833 SFE---EPE---PLEEEQSSGG--------KRPSLERLDSQVSTLHQDVAQLSAEVRNAISALQE 883
            |.:   ||.   ||.|.:....        .:..:.:|:|:|:||.|:|:||..::|:.:..|:
Mouse   834 SEQIRPEPRISPPLAESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGRDMRSIMQLLE- 897

  Fly   884 MTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGVLAAAELAAMQRSSSHPPEVW 948
                 |.::.....:|                                        .|.|
Mouse   898 -----NILSPQQPSQF----------------------------------------CSLH----- 912

  Fly   949 GRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRIDFPTFERFV--------LANPRLVLGL 1005
                            |:|:.|.:    .|.||   |:.:...:..:        |.:..:..|:
Mouse   913 ----------------PTPMCPSR----ESLQT---RVSWSAHQPCLHLQAGGAHLYHGNVASGI 954

  Fly  1006 LGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDHNLASSKERLITSSAVPTPGRIYPPLDDE 1070
            ..::|::...            ||..|.....:|:|..|..|                 |.||
Mouse   955 WSVDPSLVGS------------SPQRTEAHEQNPADSELHHS-----------------PNLD-- 988

  Fly  1071 NSNDFRWTMKHSASHHSCCKSTD-------ALLSPEEQPPISILPVDATPAPSVQEVRSSKRSLR 1128
                      :|.||   |:...       ..:||.....:       ||..|:
Mouse   989 ----------YSPSH---CQVIQEGHLQFLRCISPHSDTTL-------TPLQSI----------- 1022

  Fly  1129 KSTSGSNSSLSSSSSSSNSCLVSQS-TGNLTTTNASVHCSNSSQSVASVATTRRASWKLQHSRSG 1192
             |.:.|:|..|||.:|.:..|.|:| .|::|      |...||.|:.::.    .||..:...|.
Mouse  1023 -SATLSSSVCSSSETSLHLVLPSRSEEGSIT------HGPVSSFSLENLP----GSWDREQMMSA 1076

  Fly  1193 EYRRLSEATAEYSPPAKTPLPVAGVSYGGDEEES 1226
            ...||..            .||..|:...|.::|
Mouse  1077 SSERLEN------------FPVEVVTSTADVKDS 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	63/92 (68%)
		PLN03192	270..>650	CDD:215625	234/397 (59%)
		cNMP	586..716	CDD:197516	71/129 (55%)
Kcnh8	XP_036016335.1	PAS_9	40..135	CDD:463873	64/94 (68%)
		PLN03192	175..>616	CDD:215625	257/450 (57%)
		PRK11753	579..>657	CDD:236969	46/95 (48%)