DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh6

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001032801.1	Gene:	Kcnh6 / 192775	MGIID:	2684139	Length:	950	Species:	Mus musculus

Alignment Length:	1013	Identity:	357/1013 - (35%)
Similarity:	537/1013 - (53%)	Gaps:	137/1013 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:|||||:||||..:|:|....|::.|||.....|:||:|||.:|.||||.::||:.|:
Mouse     1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||.||:|......::.::|....|.|:::::|:|:.:.|.||.|:||:|||...|::|:.:.:
Mouse    66 CDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFE 130

  Fly   131 DITHTKMLEMNVNEECDSVFALTAALLGARF--RAGSNAGMLGLGGLPGLGGPAASDGDTEAGEG 193
            |:  .::|..:      |..:||..||...|  ..||::...|.|..||.|           ..|
Mouse   131 DL--AQLLAKS------SSRSLTQRLLSHSFLGSEGSHSRPSGQGPGPGRG-----------KYG 176

  Fly   194 NNLDVP------AGCNMGRRRSRAV--LYQLSGHYKPEKGGVKTK-----LKLGNNFMHSTEAPF 245
            ....:|      ...|:.:.||.:.  :..::.|...|:....|:     |.||.:.:
Mouse   177 TVSQIPQFTLSFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVL------- 234

  Fly   246 PEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK----------- 299
            ||||.|:.:..|..:.||..||.:|||:||:...|.|:..||:|||..:|:...
Mouse   235 PEYKLQAPRIHRGTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDDSQRGTCGYTCSP 299

  Fly   300 --VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDL 362
              |.|:||:.:|:|||::|||||:|:...||||:.::||::|.:|||.:|::||:|||.|.....
Mouse   300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTG 364

  Fly   363 YDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEW 427
            .|...:.|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.|||||||||.|...|..:
Mouse   365 SDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPY 429

  Fly   428 FPESNIGWLQ----LLAERKNAS--VAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFT 486
            . |..||||.    .|.:..|.|  .:..:..:.|.|||||||:|||||||||||.||.:||||:
Mouse   430 L-EPKIGWLDSLGAQLGKHYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFS 493

  Fly   487 IIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWS 551
            |.:||||:||:|.:||||:|||||:||..:.|.::...:|:|:..|.:|..|:||:|:|||.:||
Mouse   494 ICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWS 558

  Fly   552 LSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTNFCAPGEYLIH 615
            .::|||:...|:.|||.|:.|:.:||||.:|| .|.|..||:|||:.|::..||....||:.|:|
Mouse   559 YTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLVH 623

  Fly   616 KGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRS 680
            .||.|:.:|::..||:|:::||:|||||||.|:.|...::|.             ..|     :|
Mouse   624 LGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPASLHA-------------RPG-----KS 670

  Fly   681 SSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLR------------------ 727
            |:|::|||||||..||...|:|||.:||.:...|.|.:  ::|.|||
Mouse   671 SADVRALTYCDLHKIHRADLLEVLDMYPAFADTFWNKL--EVTFNLRDADGGLHSTPRQAPGNQD 733

  Fly   728 -EGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSP 791
             :|:...||..|.:   ||:|..|.:       |...:.....|||..:|...:...|..
Mouse   734 PQGFFLNDSQSGAA---PSLSISDTS-------GLWPELLQQMPPSPPNPREKLDCWPRE----- 783

  Fly   792 LLGMGSPRNQ----RLHQRGRS----LITLRETNKRH--RTLNAACSLDRGSFEEPEPLEEEQSS 846
             ||....:.|    ||..|..|    ::.|.:..:.|  ..|.|..|.|...|.|....:..:|.
Mouse   784 -LGFKLEQLQAQMNRLESRVSSDLSRILQLLQHPQGHPGYILGAPASSDLALFPETSVTQSSESM 847

  Fly   847 --GGKRPSLERLDSQVSTLHQDVAQ-LSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSI-P- 906
              .|..||.:.|.......|..:.: .|..:.:..:|:.:....|:.......|..|.|..: |
Mouse   848 LLVGHLPSAQTLSYGDLDKHIRMPRNFSPRIPHVAAAMDKSLVPSSEQEQPKGLLSPLASPLCPL 912

  Fly   907 NISGVAGTRSGVAVEHGLMGGVLAAAELAAMQRSSSHP 944
            .:.|:.|.......||     :.:..:....||..|.|
Mouse   913 EVQGLGGPHFSSLPEH-----LSSVPKQLEFQRHGSDP 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	36/95 (38%)
		PAS_3	41..129	CDD:285623	36/87 (41%)
		Ion_trans	285..516	CDD:278921	122/249 (49%)
		Ion_trans_2	<455..510	CDD:285168	40/54 (74%)
		Crp	583..>650	CDD:223736	32/67 (48%)
		CAP_ED	586..715	CDD:237999	51/128 (40%)
Kcnh6	NP_001032801.1	PAS_9	29..132	CDD:290162	40/102 (39%)
		PAS	41..132	CDD:238075	36/90 (40%)
		Ion_trans	296..520	CDD:278921	114/224 (51%)
		Ion_trans_2	<463..517	CDD:285168	40/53 (75%)
		Crp	588..>701	CDD:223736	54/130 (42%)
		CAP_ED	594..705	CDD:237999	51/128 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820