Protein Alignment Elk and cng-2

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_001343690.1
• Gene: cng-2 / 190732
• WormBaseID: WBGene00022295
• Length: 819
• Species: Caenorhabditis elegans
• Alignment Length: 694
• Identity: 135/694 - (19%)
• Similarity: 250/694 - (36%)
• Gaps: 221/694 - (31%)

  Fly   262 HYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTKVSDVIVEALFIVDILLNFRTTFVSRKG 326
            |:|.|.   .|:      ||.|...:                    .|::|.|:..|.|||| :|
 Worm   258 HFGYFN---QWL------YVNLFFDF--------------------CFLLDCLVGSRMTFVS-EG 292

  Fly   327 EVVSNSKQIAINYLRG-WFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDR 390
            ..||.:.::..||.:. ...||||...|      :|.|...|:...||:..||::..||.:.|..
 Worm   293 NEVSQTDKMFKNYRQSRRCKLDLLCLAP------ADFYLFIDTKASLVRAIRLVKAYRLYEFIML 351

  Fly   391 YSQHT----AMILTLLMFSFTLAAHWLACIWYVIAVKE--------------------------- 424
            ..:.|    .|.:..|..|..:..||.||::::.::.:
 Worm   352 TQRRTDFPHFMKILFLTSSCAILFHWNACVYFLFSLYQGLTEDDPNAFGFSYYKVFDPRFSICDA 416

  Fly   425 -YE---WFPESNIGWLQLLAER-------------KNASVAILTTAETYSTALYFTFTSLTSVG- 471
             |:   ::|| :...|.:..||             |...:.|...:..||..:|::..::|..|
 Worm   417 LYDQDCYYPE-DTEVLDIRDERPHYMEDMYKFWDKKFNILQIGNFSREYSMTIYWSSLTITKCGQ 480

  Fly   472 --FGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNM 534
              :.:.|:..:.|    |...|||.|:.|.:.|.|.:::.:|....:.:......:|.::....:
 Worm   481 QPWPSKSSQNSLE----IFDTLIGVLVFATIIGGVGSVVTQMSQNVNDFREMMDGIKFYMKYRGV 541

  Fly   535 PKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLL 598
            ...::.|:.:.|....|.:...|..|.|...|...:..::.:||::.| ::.:|....|..|:.:
 Worm   542 QSAIQDRVLNCFLYLNSHNQLYDEEEILSLLPPFFQARIAANLHQDTLSKVSLFYKCDQRLLQEV 606

  Fly   599 SLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAI--LGKGDLVGSDINVHLVATS 661
            .:.:|....:|.:||..|.:....::.:..|.:.||.||..|.:  |.:|...| ::::
 Worm   607 VMLVKQQVYSPNDYLCRKNEKAKEMFIVKKGLLAVIDDDTGVELDSLKEGHTFG-ELSI------ 664

  Fly   662 NGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNL 726
               :....|..|.    |.|..::::.|.|:..:|...:..:|:.|||.:.:.
 Worm   665 ---VQVKGNILGD----RRSVSLRSVGYSDVYVLHQDDVTRLLQEYPEERVRL------------ 710

  Fly   727 REGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSP 791
                                                 .||.
 Worm   711 -------------------------------------MENA------------------------ 714

  Fly   792 LLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLE----EEQSSGGKRPS 852
                    .:.||.||     |.|||:    |...|..|.| .::...||    :||
 Worm   715 --------RRMLHSRG-----LLETNE----LGEMCETDDG-LDDEAMLEFLSVDEQ-------- 753

  Fly   853 LERLDSQVSTLHQDVAQL-------SAEVRNAISALQEMTFTSN 889
            |.||::.:.::..|:|.:       |...:..::||:.: |.||
 Worm   754 LNRLENIIDSIDTDLANMITSFSYNSVAYKKRVTALENI-FNSN 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873
		PLN03192	270..>650	CDD:215625	91/434 (21%)
		cNMP	586..716	CDD:197516	28/131 (21%)
cng-2	NP_001343690.1	Ion_trans	232..>407	CDD:459842	43/184 (23%)
		PLN03192	<457..>713	CDD:215625	56/322 (17%)
		CAP_ED	594..711	CDD:237999	28/179 (16%)