DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh5

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_598294.1	Gene:	Kcnh5 / 171146	RGDID:	621417	Length:	988	Species:	Rattus norvegicus

Alignment Length:	1106	Identity:	341/1106 - (30%)
Similarity:	524/1106 - (47%)	Gaps:	233/1106 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MP-ARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            || .::||:|||||||:.|..|  .:.|:|:|||||....|:||.:|||..|:||.||.:|||..
  Rat     1 MPGGKRGLVAPQNTFLENIVRR--SSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSS 63

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            :|.|:||..|.::..:::.::..|......||:.|||...|.|....|.||:||...|||||.:.
  Rat    64 TCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTF 128

  Fly   130 KDITHTKM-LEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEG 193
            ||||..|. :|.:..:.......||.||
  Rat   129 KDITLFKQPIEDDSTKGWTKFARLTRAL------------------------------------- 156

  Fly   194 NNLDVPAGCNMGRRRSRAVLYQLSGHYKPE----KGGVKTKLKLGNNFMHSTEAPFPEYKTQSIK 254
                         ..||:||.||:...|.|    ...:...|:||::.:       |:||.::.|
  Rat   157 -------------TNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGSDIL-------PQYKQEAPK 201

  Fly   255 KSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK-------VSDVIVEALFIVD 312
            ....|:.||..||..||||||:.|||.|:|||||.:|     :||       |.|.:|:.:|:||
  Rat   202 TPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF-----KTKQNNIAWLVLDSVVDVIFLVD 261

  Fly   313 ILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYD-GEDSHIHLVKLT 376
            |:|||.||||...|||:|:.|.|.:|||:.||.:|||:.||:|.:.|.:..| |..|....:|:.
  Rat   262 IVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVV 326

  Fly   377 RLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFPE-SNI----GWL 436
            |||||.|:.:|:|.|.::.|.:|.||:..|.|.|||||||||  ::.:||...| :|.    .||
  Rat   327 RLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWY--SIGDYEVIDEVTNTIQIDSWL 389

  Fly   437 QLLA------ERKNASVAIL----TTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMML 491
            ..||      .|.|.|..|.    :....|.::||||.||||::||||::..|..||:|::.||:
  Rat   390 YQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 454

  Fly   492 IGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGI 556
            :|:|::|.:|||||.|.|:||:..:.|.....:::||:.|:.:||.|.:|:.||..::||:|.||
  Rat   455 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGI 519

  Fly   557 DIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDAL 620
            |..:.|...|:::|.|:.:||:|::. :.|.|..||.|||:.|::..:|..||||:.:.|.|:::
  Rat   520 DTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESV 584

  Fly   621 NYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIK 685
            :.:.::.:||:|||:|:.|||||||||:.| ||          ....||       :..:.::::
  Rat   585 DALCFVVSGSLEVIQDEEVVAILGKGDVFG-DI----------FWKETT-------LAHACANVR 631

  Fly   686 ALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLR---------------EGYENQDS 735
            |||||||..|....|::||..|..:...|:.::  .||||||               |....|.:
  Rat   632 ALTYCDLHIIKREALLKVLDFYTAFANSFSRNL--TLTCNLRKRIIFRKISDVKKEEEERLRQKN 694

  Fly   736 DIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSPRN 800
            ::..|.|:      |....:..:..|.:||           |.|..::.....||.|.....|..
  Rat   695 EVTLSIPV------DHPVRKLFQKFKQQKE-----------LRNQGSAQSDPERSQLQVESRPLQ 742

  Fly   801 QRLHQRGRSLITLRETN---------KRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERL 856
            ......|.|::|:.:..         |...||.          :......|.:.:||..|...::
  Rat   743 NGASITGTSVVTVSQITPIQTSLAYVKTSETLK----------QNNRDAMELKPNGGAEPKCLKV 797

  Fly   857 DSQVST----------------LHQDVAQLSAEVRNAISALQEMTFTS---NAMTSHSSLKFPPA 902
            :|.:..                .|::    ..|..|.::..:.|...|   ....|.:|:...|.
  Rat   798 NSPIRMKNGNGKGWLRLKNNMGAHEE----KKEEWNNVTKAESMGLLSEDPKGSDSENSVTKNPL 858

  Fly   903 RSIPNI-SGVAGTRSGVAVEHGLMGGVLAAAELAAMQRSSSHP----PEVWGRDVQLPTSNTASS 962
            |...:. ||:  |:|.:.::..  |...:..|.:..|..:.||    ||
  Rat   859 RKTDSCDSGI--TKSDLRLDKA--GEARSPLEHSPSQADAKHPFYPIPE---------------- 903

  Fly   963 KAPSPVEPKKTMTSRSSQTDFYRIDFPTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQI 1027
                          ::.||....:.....|...|.:.|:.    .:|..:...:.||.:|...|.
  Rat   904 --------------QALQTTLQEVKHELKEDIQLLSCRMT----ALEKQVAEILKLLSEKSVPQT 950

  Fly  1028 S 1028
            |
  Rat   951 S 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	38/95 (40%)
		PAS_3	41..129	CDD:285623	36/87 (41%)
		Ion_trans	285..516	CDD:278921	110/253 (43%)
		Ion_trans_2	<455..510	CDD:285168	28/54 (52%)
		Crp	583..>650	CDD:223736	30/66 (45%)
		CAP_ED	586..715	CDD:237999	46/128 (36%)
Kcnh5	NP_598294.1	PAS_9	39..132	CDD:404329	39/92 (42%)
		PLN03192	217..>616	CDD:215625	175/406 (43%)
		Selectivity filter. /evidence=ECO:0000250	432..437		2/4 (50%)
		Crp	544..723	CDD:223736	64/215 (30%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..742		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..897		12/61 (20%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..965		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338743
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840