DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh3

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_006520546.1	Gene:	Kcnh3 / 16512	MGIID:	1341723	Length:	1101	Species:	Mus musculus

Alignment Length:	1133	Identity:	452/1133 - (39%)
Similarity:	593/1133 - (52%)	Gaps:	260/1133 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANG-NPIVYCSDGFVDLTGYSRAQIMQKGC 64
            |||.:||||||||||||||||||||||||||||||..| .|:|||||||.||||:|||::||:||
Mouse     1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            :|.|||||||.|..:|||.|:|....|.|.|:|.|:|.|.|||||.|::||||||.:|.|||.||
Mouse    66 ACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSH 130

  Fly   130 KDITHTKMLEMNVN-EECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEG 193
            |||:.||......| :|.:..|     |:|...|....||..|.
Mouse   131 KDISETKNRGGPDNWKEREPSF-----LVGGGRRRYGRAGSKGF--------------------- 169

  Fly   194 NNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRL 258
                     |..|||||||||.||||.:.:..| |.||..|   :...:...||||..:|:||..
Mouse   170 ---------NANRRRSRAVLYHLSGHLQKQPKG-KHKLNKG---VFGEKPNLPEYKVAAIRKSPF 221

  Fly   259 ILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQT------KVSDVIVEALFIVDILLNF 317
            ||.|.|..:..||..||:||.|||:.|||:...:.|...:      .|.|:.||.|||:||:|||
Mouse   222 ILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNF 286

  Fly   318 RTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFD--HLYASDLYDGEDSHIHLVKLTRLLR 380
            ||||||:.|:||...|.|.::|:..||.||::||||||  |.:..::|.|    .||:|..||||
Mouse   287 RTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVG----AHLLKTVRLLR 347

  Fly   381 LARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE----WFPESNIGWLQLLAE 441
            |.|||.::|||||::|::|||||..|.|.|||:||:|:.|..:|.|    ..||  |||||.||.
Mouse   348 LLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPE--IGWLQELAR 410

  Fly   442 R---------------------KNASVAILTTA-----------------------ETYSTALYF 462
            |                     :|.|.:..::.                       ..|.|:|||
Mouse   411 RLETPYYLVSRSPDGGNSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYF 475

  Fly   463 TFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKD 527
            ..:||||||||||||||..||:|:|..|||||||||||||||||||||||:||.||.|:.|||:|
Mouse   476 ALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRD 540

  Fly   528 FVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREILQLPIFEAASQ 592
            ::.:|.:||.||||:.:|||.:|::::|||..|.|:..|:|||.|::||||:|:||||:|||||:
Mouse   541 YIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASR 605

  Fly   593 GCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHL 657
            |||:.|||.::..||.|||||||:||||..:|::|:|||||:|...|:||||||||:|.::
Mouse   606 GCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCEL---- 666

  Fly   658 VATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDL 722
                          ..::.||::::|:|.||||.|:|:.:.||.|.|.||||:..:|:..::.:|
Mouse   667 --------------PQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGEL 717

  Fly   723 TCNLREGYENQDSDIGPSFPLPSISEDD---ENREEAEEGGKGEKENGGGPPSGASPLHNISNSP 784
            :.||..|..:.:.|..      |:|.|:   ...||.|..|    |.|          |.:|.:|
Mouse   718 SYNLGAGGVSAEVDTS------SLSGDNTLMSTLEEKETDG----EQG----------HTVSPAP 762

  Fly   785 LHATRSPLLGMG-----------SPR----NQRLHQRGR----SLITLRETNKRH-RTLNA---- 825
            .....||||..|           |||    ..||..|||    .::........| |:|:.
Mouse   763 ADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRSLDGLQLP 827

  Fly   826 --------------------ACSLDRGSF------------EEPEPLEEEQSSG------GKRPS 852
                                .||.|:..|            ..|.|..|   ||      |  ||
Mouse   828 PMPWNVPPDLSPRVVDGIEDGCSSDQPKFSFRVGQSGPECSSSPSPGTE---SGLLTVPLG--PS 887

  Fly   853 LERLDSQVSTLHQDVAQLSAEV---RNAISALQEMTFTSNAMTSHSSLKFPPAR-SIPNISG--- 910
            ..|....:..|.|.|.:||.:|   |..:.:|::..         ..:..|... ..|..||
Mouse   888 EARNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAV---------QLILVPQGEGQCPRGSGEEP 943

  Fly   911 VAGTRSG----VAVEHGLMGGVLAAAELAAMQRSSSHP----------PEVWG------------ 949
            ...|.||    :.|:.|.....|.....:.:..:..||          |..||
Mouse   944 CPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGQPPPLMAPWPWGPPASQSSPWPRA 1008

  Fly   950 -------RDVQLPTSNTASSKAPSPVEP 970
                   .|.:.|.|....|:..:|..|
Mouse  1009 TALWTSTSDSEPPGSGDLCSEPSTPASP 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	60/96 (63%)
		PAS_3	41..129	CDD:285623	55/87 (63%)
		Ion_trans	285..516	CDD:278921	133/286 (47%)
		Ion_trans_2	<455..510	CDD:285168	42/54 (78%)
		Crp	583..>650	CDD:223736	44/66 (67%)
		CAP_ED	586..715	CDD:237999	60/128 (47%)
Kcnh3	XP_006520546.1	PAS_9	40..135	CDD:379177	61/94 (65%)
		PLN03192	233..>668	CDD:215625	222/458 (48%)
		cyc_nuc_ocin	<623..718	CDD:274839	47/112 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835154
Domainoid	1	1.000	278	1.000	Domainoid score	I1692
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I514
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48155
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm42392
orthoMCL	1	0.900	-	-		OOG6_104228
Panther	1	1.100	-	-	LDO	PTHR10217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4902
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800