DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh2

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_038597.2	Gene:	Kcnh2 / 16511	MGIID:	1341722	Length:	1162	Species:	Mus musculus

Alignment Length:	1259	Identity:	384/1259 - (30%)
Similarity:	564/1259 - (44%)	Gaps:	342/1259 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:||||||||||..:|:|....|::.||:.....::||:|||.:|.|||||::||:.|:
Mouse     1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||:||.|:.....||.::|....|.|:|:.||:|:|:.|.||.|:||:|||...|::|:.:.:
Mouse    66 CDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFE 130

  Fly   131 DITHTKMLEMNVNE---------------------ECDSVFALTAALLGARFRAGSNAG------ 168
            .:....|:....::                     :..::.||||.....|..:..:||
Mouse   131 VVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESSVRTGSMRSAGAPGAVV 195

  Fly   169 --------------------------MLGLGGL--------PGLGGPAAS-DGDTEAGEGNNLDV 198
                                      :.|||..        ||...|.|| .|...:....:|:.
Mouse   196 VDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPGSASPVASIRGPHPSPRAQSLNP 260

  Fly   199 PA---GCNMGRRRSRAVL-------------------------YQLSGHYKPEKGGV-------- 227
            .|   .|::.|.|||...                         :..:|...|.:.|:
Mouse   261 DASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPPPPRHASTGAMHPLRSGLLNSTSDSD 325

  Fly   228 ----KTKLKLGN---NFMHSTEAPF-------------------------------------PEY 248
                :|..|:..   ||:.....||                                     |||
Mouse   326 LVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEY 390

  Fly   249 KTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAF--------------AKADRQTK 299
            |.|:.:..|..:.||..||.:|||:||:...|.|:..||:|||              ..|.:...
Mouse   391 KLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLA 455

  Fly   300 VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYD 364
            |.|:||:.:||||||:|||||:|:...||||:..:||::|.:|||.:|::||:|||.|...   .
Mouse   456 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFG---S 517

  Fly   365 GEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFP 429
            |.:..|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.|||||||||.|...|....
Mouse   518 GSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHM- 581

  Fly   430 ESNIGWLQLLAER-----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIM 489
            :|:||||..|.::     .::.:...:..:.|.|||||||:|||||||||||.||.:||:|:|.:
Mouse   582 DSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICV 646

  Fly   490 MLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSH 554
            ||||:||:|.:||||:|||||:||..:.|.::...:::|:..|.:|..|:||:|:|||.:||.::
Mouse   647 MLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTN 711

  Fly   555 GIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGD 618
            |||:...|:.|||.|:.|:.:||:|.:|| ...|..|::|||:.|::..||....||:.|:|.||
Mouse   712 GIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGD 776

  Fly   619 ALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHL-VATSNGQMTATTNSAGQDVVVRSSS 682
            .|..:|::..||:|:::.|:|||||||.|:.|..:|::. ...|||
Mouse   777 LLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNG------------------- 822

  Fly   683 DIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSIS 747
            |::|||||||..||...|:|||.:|||:...|.:.:  ::|.|||      |:::.|..|..:..
Mouse   823 DVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EITFNLR------DTNMIPGSPGSAEL 879

  Fly   748 EDDENRE-------------------EAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLL 793
            |...||:                   |....|:|....|.||.....|     ..|.  ..||..
Mouse   880 ESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQP-----GGPW--GESPSS 937

  Fly   794 GMGSPRNQRLHQRGRSLITLR--------------------ETNKRHRTLNAACSLDRG------ 832
            |..||.:......|||...||                    |..::..|.|.......|
Mouse   938 GPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDPPGGEPLTEDGEKSDTCNPLSGAFSGVSNIFS 1002

  Fly   833 --------SFEE--------PEPLEEEQSSGGKRPSLE---RLDSQVSTLHQDVAQLSAEVRNAI 878
                    .::|        |..|....||.|:|...:   |||:....|::...:|||::...:
Mouse  1003 FWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVL 1067

  Fly   879 SALQ-EMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGVLAAAELAAMQRSSS 942
            ..|| :||..            |||.|.
Mouse  1068 QLLQRQMTLV------------PPAYSA------------------------------------- 1083

  Fly   943 HPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRS-SQTDFYRIDFPTFERFVLANPRL----- 1001
                     |..|.....|:....||.|..|:|..| ||..    .|..||......|.|
Mouse  1084 ---------VTTPGPGPTSASPLLPVGPVPTLTLDSLSQVS----QFVAFEELPAGAPELPQDGP 1135

  Fly  1002 --------VLGLLGIEPAIKNEMD 1017
                    .||.|..:|..::..|
Mouse  1136 TRRLSLPGQLGALTSQPLHRHGSD 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	41/95 (43%)
		PAS_3	41..129	CDD:285623	41/87 (47%)
		Ion_trans	285..516	CDD:278921	121/249 (49%)
		Ion_trans_2	<455..510	CDD:285168	39/54 (72%)
		Crp	583..>650	CDD:223736	29/67 (43%)
		CAP_ED	586..715	CDD:237999	50/129 (39%)
Kcnh2	NP_038597.2	PAS_9	29..130	CDD:290162	44/100 (44%)
		PAS	41..132	CDD:238075	41/90 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..316		15/82 (18%)
		Ion_trans	451..670	CDD:278921	113/222 (51%)
		Ion_trans_2	<613..667	CDD:285168	39/53 (74%)
		Selectivity filter. /evidence=ECO:0000250	626..631		4/4 (100%)
		Crp	738..>858	CDD:223736	53/138 (38%)
		CAP_ED	744..855	CDD:237999	50/129 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..991		25/124 (20%)
		SSTK-IP	1015..1116	CDD:292464	32/162 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1162		7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750