Protein Alignment Elk and Hcn1

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_034538.2
• Gene: Hcn1 / 15165
• MGIID: 1096392
• Length: 910
• Species: Mus musculus
• Alignment Length: 1010
• Identity: 215/1010 - (21%)
• Similarity: 396/1010 - (39%)
• Gaps: 226/1010 - (22%)

  Fly   141 NVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASD-------------GDTEAGE 192
            |..::.:|||...|.      ..|..|....||..|| ||.|..:             |:..||.
Mouse    12 NSRDDGNSVFPSKAP------ATGPVAADKRLGTPPG-GGAAGKEHGNSVCFKVDGGGGEEPAGS 69

  Fly   193 GNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSR 257
            ..:.:.|      ||:...:..|.:...:|   ||.   |.......|.:|  .|.:.:.:|.:.
Mouse    70 FEDAEGP------RRQYGFMQRQFTSMLQP---GVN---KFSLRMFGSQKA--VEKEQERVKTAG 120

  Fly   258 LILPH-YGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK--VSDVIVEALFIVDILLNFRT 319
            ..:.| |..|:..||.::|:......:::|....|......|.  :.:|..:.:|::|:::||||
Mouse   121 FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRT 185

  Fly   320 TFVSR-KGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIH------------ 371
            ..|:. ..|::.:.|.|.:|||:.||.:|.::::|.|:::.. :..|.||.::
Mouse   186 GTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLI-VEKGMDSEVYKTARALRIVRFT 249

  Fly   372 -LVKLTRLLRLARLLQKIDRYSQHTAMILTL---------LMFSFTLAAHWLACIWYVIAVKEYE 426
             ::.|.|||||:||::.|.::.:...|...|         |:....|..||..|:.:::.:.: :
Mouse   250 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQ-D 313

  Fly   427 WFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMML 491
            :.|:.   |:. |.|..|.|     ..:.||.||:...:.:..:|:|..:..:.::...|::.|:
Mouse   314 FPPDC---WVS-LNEMVNDS-----WGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMI 369

  Fly   492 IGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGI 556
            :||..:|:..|:.||:||.:.|.|..|:.|::.::.:::.|.:|.:::|:|.||::..:. ....
Mouse   370 VGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIF 433

  Fly   557 DIYETLREFPEELRGD-VSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDAL 620
            |....|.|..:.||.: |:.:..:.:..:|:|..|....:..:...::.....||:|:|.:|...
Mouse   434 DEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVG 498

  Fly   621 NYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIK 685
            ..:|::.:|...||........|..|...|     .:...:.|:.||:               ::
Mouse   499 KKMYFIQHGVAGVITKSSKEMKLTDGSYFG-----EICLLTKGRRTAS---------------VR 543

  Fly   686 ALTYCDLKCIHMGGLVEVLRLYPEYQQQF-------------ANDI-----QHDLTCNLREGYEN 732
            |.|||.|..:.:....|||..||..::.|             .|.|     |.||...:   :.|
Mouse   544 ADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGV---FNN 605

  Fly   733 QDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGS 797
            |:::|     |..|.:.|....:|                 ..|::....:.|:.|.|
Mouse   606 QENEI-----LKQIVKHDREMVQA-----------------IPPINYPQMTALNCTSS------- 641

  Fly   798 PRNQRLHQRGRSLITLRETNKRHRT----LNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDS 858
                          |...|: |.||    :..|.||...:...|.|     |:...:||     :
Mouse   642 --------------TTTPTS-RMRTQSPPVYTATSLSHSNLHSPSP-----STQTPQPS-----A 681

  Fly   859 QVSTLHQDVAQLSAEVRNAISALQEMTF-TSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEH 922
            .:|......|..|..::   |.|...|| .::...|..||...|.:.:|. |.|..|::....:.
Mouse   682 ILSPCSYTTAVCSPPIQ---SPLATRTFHYASPTASQLSLMQQPQQQLPQ-SQVQQTQTQTQQQQ 742

  Fly   923 GLMGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRID 987
                  ....:....|:......:...:..|.........:.|....||..: .:|:|
Mouse   743 ------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEV-HKSTQ------- 793

  Fly   988 FPTFERFVLANPRL---VLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDHNLASSKE 1049
                   .|.|..|   |..|...:|::.:|:      .||...|..|:.|.::.....:|:...
Mouse   794 -------ALHNTNLTKEVRPLSASQPSLPHEV------STLISRPHPTVGESLASIPQPVAAVHS 845

  Fly  1050 ------------------RLITSSAVPTPGRIYPP 1066
                              |.::|.|:| |.|..||
Mouse   846 TGLQAGSRSTVPQRVTLFRQMSSGAIP-PNRGVPP 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873
		PLN03192	270..>650	CDD:215625	96/405 (24%)
		cNMP	586..716	CDD:197516	28/142 (20%)
Hcn1	NP_034538.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		17/69 (25%)
		Ion_trans_N	87..129	CDD:400630	10/49 (20%)
		PLN03192	122..>609	CDD:215625	121/521 (23%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:12089064	347..351		1/3 (33%)
		CAP_ED	464..572	CDD:237999	27/127 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..681		16/78 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	771..791		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..910		7/16 (44%)