DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Hcn1

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_034538.2	Gene:	Hcn1 / 15165	MGIID:	1096392	Length:	910	Species:	Mus musculus

Alignment Length:	1010	Identity:	215/1010 - (21%)
Similarity:	396/1010 - (39%)	Gaps:	226/1010 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 NVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASD-------------GDTEAGE 192
            |..::.:|||...|.      ..|..|....||..|| ||.|..:             |:..||.
Mouse    12 NSRDDGNSVFPSKAP------ATGPVAADKRLGTPPG-GGAAGKEHGNSVCFKVDGGGGEEPAGS 69

  Fly   193 GNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSR 257
            ..:.:.|      ||:...:..|.:...:|   ||.   |.......|.:|  .|.:.:.:|.:.
Mouse    70 FEDAEGP------RRQYGFMQRQFTSMLQP---GVN---KFSLRMFGSQKA--VEKEQERVKTAG 120

  Fly   258 LILPH-YGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK--VSDVIVEALFIVDILLNFRT 319
            ..:.| |..|:..||.::|:......:::|....|......|.  :.:|..:.:|::|:::||||
Mouse   121 FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRT 185

  Fly   320 TFVSR-KGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIH------------ 371
            ..|:. ..|::.:.|.|.:|||:.||.:|.::::|.|:::.. :..|.||.::
Mouse   186 GTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLI-VEKGMDSEVYKTARALRIVRFT 249

  Fly   372 -LVKLTRLLRLARLLQKIDRYSQHTAMILTL---------LMFSFTLAAHWLACIWYVIAVKEYE 426
             ::.|.|||||:||::.|.::.:...|...|         |:....|..||..|:.:::.:.: :
Mouse   250 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQ-D 313

  Fly   427 WFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMML 491
            :.|:.   |:. |.|..|.|     ..:.||.||:...:.:..:|:|..:..:.::...|::.|:
Mouse   314 FPPDC---WVS-LNEMVNDS-----WGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMI 369

  Fly   492 IGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGI 556
            :||..:|:..|:.||:||.:.|.|..|:.|::.::.:::.|.:|.:::|:|.||::..:. ....
Mouse   370 VGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIF 433

  Fly   557 DIYETLREFPEELRGD-VSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDAL 620
            |....|.|..:.||.: |:.:..:.:..:|:|..|....:..:...::.....||:|:|.:|...
Mouse   434 DEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVG 498

  Fly   621 NYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIK 685
            ..:|::.:|...||........|..|...|     .:...:.|:.||:               ::
Mouse   499 KKMYFIQHGVAGVITKSSKEMKLTDGSYFG-----EICLLTKGRRTAS---------------VR 543

  Fly   686 ALTYCDLKCIHMGGLVEVLRLYPEYQQQF-------------ANDI-----QHDLTCNLREGYEN 732
            |.|||.|..:.:....|||..||..::.|             .|.|     |.||...:   :.|
Mouse   544 ADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGV---FNN 605

  Fly   733 QDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGS 797
            |:::|     |..|.:.|....:|                 ..|::....:.|:.|.|
Mouse   606 QENEI-----LKQIVKHDREMVQA-----------------IPPINYPQMTALNCTSS------- 641

  Fly   798 PRNQRLHQRGRSLITLRETNKRHRT----LNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDS 858
                          |...|: |.||    :..|.||...:...|.|     |:...:||     :
Mouse   642 --------------TTTPTS-RMRTQSPPVYTATSLSHSNLHSPSP-----STQTPQPS-----A 681

  Fly   859 QVSTLHQDVAQLSAEVRNAISALQEMTF-TSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEH 922
            .:|......|..|..::   |.|...|| .::...|..||...|.:.:|. |.|..|::....:.
Mouse   682 ILSPCSYTTAVCSPPIQ---SPLATRTFHYASPTASQLSLMQQPQQQLPQ-SQVQQTQTQTQQQQ 742

  Fly   923 GLMGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRID 987
                  ....:....|:......:...:..|.........:.|....||..: .:|:|
Mouse   743 ------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEV-HKSTQ------- 793

  Fly   988 FPTFERFVLANPRL---VLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDHNLASSKE 1049
                   .|.|..|   |..|...:|::.:|:      .||...|..|:.|.::.....:|:...
Mouse   794 -------ALHNTNLTKEVRPLSASQPSLPHEV------STLISRPHPTVGESLASIPQPVAAVHS 845

  Fly  1050 ------------------RLITSSAVPTPGRIYPP 1066
                              |.::|.|:| |.|..||
Mouse   846 TGLQAGSRSTVPQRVTLFRQMSSGAIP-PNRGVPP 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	64/255 (25%)
		Ion_trans_2	<455..510	CDD:285168	15/54 (28%)
		Crp	583..>650	CDD:223736	14/66 (21%)
		CAP_ED	586..715	CDD:237999	28/141 (20%)
Hcn1	NP_034538.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		17/69 (25%)
		Ion_trans_N	87..129	CDD:285597	10/49 (20%)
		Ion_trans	149..394	CDD:278921	64/255 (25%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:12089064	347..351		1/3 (33%)
		Crp	458..>593	CDD:223736	31/154 (20%)
		CAP_ED	464..572	CDD:237999	27/127 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..681		16/78 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..791		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..910		7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740