DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Elk and KCNH8

DIOPT Version :9

Sequence 1:NP_477009.1 Gene:Elk / 37047 FlyBaseID:FBgn0011589 Length:1284 Species:Drosophila melanogaster
Sequence 2:XP_016861187.1 Gene:KCNH8 / 131096 HGNCID:18864 Length:1108 Species:Homo sapiens


Alignment Length:1255 Identity:514/1255 - (40%)
Similarity:679/1255 - (54%) Gaps:282/1255 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||||||||||||:|.||| |.|.|||||||||.:|.|::|.::|||.|
Human     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            ||.||:|.:|.|:...||||||..|.|.|.|::||||.|:|||||.|||||||||.||||||||.
Human    66 SCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            ||||.||:.....:::.|.|        ..|.|||::                            
Human   131 KDITDTKVKITPEDKKEDKV--------KGRSRAGTH---------------------------- 159

  Fly   195 NLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLI 259
                   .:..|||||||||.:|||.:..:   |.|||:.||......| |||||....|||:.|
Human   160 -------FDSARRRSRAVLYHISGHLQRRE---KNKLKINNNVFVDKPA-FPEYKVSDAKKSKFI 213

  Fly   260 LPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD-----RQTKVSDVIVEALFIVDILLNFRT 319
            |.|:..||..|||:||:||||||:.||||..|...|     |.|.|||:.||.|||:||:|||||
Human   214 LLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRT 278

  Fly   320 TFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARL 384
            |:||:.|:|:..::.|.|:|:..||.:||:||||||.|||.::  ...|.:||:|..|||||.||
Human   279 TYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNV--TVVSLVHLLKTVRLLRLLRL 341

  Fly   385 LQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWLQLLAER- 442
            |||:||||||:.::|||||..|.|.|||:|||||||...|.|      |    .:|||..|.:| 
Human   342 LQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKW----EVGWLHELGKRL 402

  Fly   443 -----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFG 502
                 .|.::...:....|..|||||.:||||||||||||||.|||:|:|..|||||||||:|||
Human   403 ESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFG 467

  Fly   503 NVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPE 567
            ||||||||||||.|||.::.:|||||:.:|::|::||||:.:||||:||:::|||..|.|::||:
Human   468 NVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPD 532

  Fly   568 ELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSME 632
            |||.|::|||::|||||.:||.||:|||:.|||||||:||||||||:.:||||..||::|:||||
Human   533 ELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSME 597

  Fly   633 VIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHM 697
            |:||.||:||||||||:|:::::                  :|.|:::::|:||||||||:||.:
Human   598 VLKDSMVLAILGKGDLIGANLSI------------------KDQVIKTNADVKALTYCDLQCIIL 644

  Fly   698 GGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYE-------NQDSDIGPSFP---------LPSI 746
            .||.|||.|||||..:|..|||||||.|||||:|       :..|.:..|.|         ||||
Human   645 KGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSI 709

  Fly   747 SEDDENREEAEE------------GGKGEKENGGGP-----------PSGASPLHNISNSPLHAT 788
            .||:|..||.||            |.....:..|..           .||..|.|    ||:..:
Human   710 VEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFH----SPIRVS 770

  Fly   789 RSPLLGMGSPRNQRLHQRGRSLITLRETNKRHR--------TLNAACSLDRGSFEEPEPLEEEQS 845
            ||     .||:.       :..|.....|||..        |||.|...|.......:.:|:..|
Human   771 RS-----NSPKT-------KQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPSRIVDGIEDGNS 823

  Fly   846 S--------GGKR-----------------------------PSLERLDSQVSTLHQDVAQLSAE 873
            |        |.:|                             ..:.:|:|:|:||.|:|:||..:
Human   824 SEESQTFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKD 888

  Fly   874 VRNAISALQEMTF---TSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVE----HGLMGGVLAA 931
            :||.|..|:.:..   .|...:.||:...|...|:.       ||:..:..    |...||   |
Human   889 MRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQ-------TRTSWSAHQPCLHLQTGG---A 943

  Fly   932 AELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPV--EPKKTMTSRSSQTDFYRIDFPTFERF 994
            |...|...||:...::|..|             ||.|  .|::|.....:..|......|:    
Human   944 AYTQAQLCSSNITSDIWSVD-------------PSSVGSSPQRTGAHEQNPADSELYHSPS---- 991

  Fly   995 VLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSP-SD------HNLASSKERLI 1052
                       |...|:         ..|.:|...|..: .|:|| ||      .:::::....:
Human   992 -----------LDYSPS---------HYQVVQEGHLQFL-RCISPHSDSTLTPLQSISATLSSSV 1035

  Fly  1053 TSSAVPTPGRIYPPLDDENS------NDF-------RWTMKHSASHHSCCKSTDALLSPEEQPPI 1104
            .||:..:...:.|...:|.|      :.|       .|..:..||         |...|.|..|:
Human  1036 CSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMAS---------ASTKPLENLPL 1091

  Fly  1105 SILPVDATPAPSVQEVRSSK 1124
            .::       .|..||:.:|
Human  1092 EVV-------TSTAEVKDNK 1104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ElkNP_477009.1 PAS 36..132 CDD:238075 63/95 (66%)
PAS_3 41..129 CDD:285623 58/87 (67%)
Ion_trans 285..516 CDD:278921 139/247 (56%)
Ion_trans_2 <455..510 CDD:285168 43/54 (80%)
Crp 583..>650 CDD:223736 48/66 (73%)
CAP_ED 586..715 CDD:237999 70/128 (55%)
KCNH8XP_016861187.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145052
Domainoid 1 1.000 279 1.000 Domainoid score I1701
eggNOG 1 0.900 - - E1_KOG0498
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 792 1.000 Inparanoid score I517
Isobase 1 0.950 - 0 Normalized mean entropy S4232
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D247304at2759
OrthoFinder 1 1.000 - - FOG0000148
OrthoInspector 1 1.000 - - otm40327
orthoMCL 1 0.900 - - OOG6_104228
Panther 1 1.100 - - O PTHR10217
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4902
SonicParanoid 1 1.000 - - X71
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.740

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