Protein Alignment Elk and CNGA1

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_005248106.3
• Gene: CNGA1 / 1259
• HGNCID: 2148
• Length: 690
• Species: Homo sapiens
• Alignment Length: 721
• Identity: 158/721 - (21%)
• Similarity: 286/721 - (39%)
• Gaps: 196/721 - (27%)

  Fly   222 PEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVP 286
            |||     |.|..:......|....:.|.:..|:..:|.|....:   ::|:     |.:.|.|.
Human   126 PEK-----KKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTY---YNWL-----FCITLPVM 177

  Fly   287 YN--AAFAKA---DRQTK------VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYL 340
            ||  ...|:|   :.|:.      :.|.:.:.::::|:.:..||.:: .:|.:|....::...|.
Human   178 YNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYL-EQGLLVKEELKLINKYK 241

  Fly   341 RG-WFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHT-----AMIL 399
            .. .|.||:|:.:|.|.||....::..:     ::|.||||.:|:.:...|....|     ..|.
Human   242 SNLQFKLDVLSLIPTDLLYFKLGWNYPE-----IRLNRLLRFSRMFEFFQRTETRTNYPNIFRIS 301

  Fly   400 TLLMFSFTLAAHWLACIWY----VIAVKEYEW-FPESNIGWLQLLAERKNASVAILTTAETYSTA 459
            .|:|: ..:..||.||::|    .|......| :|:.|......||.:             |..:
Human   302 NLVMY-IVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARK-------------YVYS 352

  Fly   460 LYFTFTSLTSVGFGNVSANT-----TAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYE 519
            ||::..:||::|      .|     .:|.||.::..|||.|:.|.:.||:.::|..|.:.|:.::
Human   353 LYWSTLTLTTIG------ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQ 411

  Fly   520 SKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREIL-Q 583
            ::...:|.::...|:.|::::|:..:|...|:....:|..|.|:..|::||.::::::|.:.| :
Human   412 ARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKK 476

  Fly   584 LPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVV--AILGKG 646
            :.||.....|.|..|.|.::....:||:|:..|||....:|.:..|.:.|:.||.|.  .:|..|
Human   477 VRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDG 541

  Fly   647 DLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQ 711
            ...| :|::             .|..|.....|.:::||::.|.||.|:....|:|.|..||:.:
Human   542 SYFG-EISI-------------LNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAK 592

  Fly   712 QQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASP 776
            ...                                          ||.||
Human   593 TML------------------------------------------EEKGK--------------- 600

  Fly   777 LHNISNSPLHATRSPLLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLE 841
                                    |.|.:.|  |:.|...|             .||  :|:.||
Human   601 ------------------------QILMKDG--LLDLNIAN-------------AGS--DPKDLE 624

  Fly   842 EEQSSGGKRPSLERLDSQVSTLHQDVAQLSAEVRNAISAL-QEMTFTSNAM-----TSHSSLKFP 900
            |:         :.|::..|..|....|::.||..:....| |.:|.....:     |..||::.|
Human   625 EK---------VTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGP 680

  Fly   901 PARSIP 906
            .|.|.|
Human   681 GAESGP 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873
		PLN03192	270..>650	CDD:215625	100/409 (24%)
		cNMP	586..716	CDD:197516	36/131 (27%)
CNGA1	XP_005248106.3	Ion_trans	165..407	CDD:459842	65/275 (24%)
		CAP_ED	479..595	CDD:237999	36/129 (28%)
		CLZ	595..664	CDD:465160	25/175 (14%)