Protein Alignment Elk and Kcnh2

DIOPT Version :9

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_006235929.2
• Gene: Kcnh2 / 117018
• RGDID: 621414
• Length: 1234
• Species: Rattus norvegicus
• Alignment Length: 1210
• Identity: 372/1210 - (30%)
• Similarity: 549/1210 - (45%)
• Gaps: 291/1210 - (24%)

  Fly    25 THSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCSCHFLYGPDTKEEHKQQIEKSLSNK 89
            |...|::.||:.....::||:|||.:|.|||||::||:.|:|.||:||.|:.....||.::|...
  Rat    96 TGRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGA 160

  Fly    90 MELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHKDITHTKMLEMNVNE---------- 144
            .|.|:|:.||:|:|:.|.||.|:||:|||...|::|:.:.:.:....|:....::
  Rat   161 EERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSW 225

  Fly   145 -----------ECDSVFALTAALLGARFRAGSNAGMLGLGGLPG--------------------- 177
                       :..::.||||.  .:..|.||.    |..|.||
  Rat   226 LASGRAKTFRLKLPALLALTAR--ESPMRTGST----GSPGAPGAVVVDVDLTPAAPSSESLALD 284

  Fly   178 --------------------LGGPAASD------GDTEAGEGNNLDVPA---GCNMGRRRSRAVL 213
                                |.|||::.      |...:....:|:..|   .|::.|.|||...
  Rat   285 EVSAMDNHVAGLGPAEERRALVGPASASPVASIRGPHPSPPAQSLNPDASGSSCSLARTRSRESC 349

  Fly   214 -------------------------YQLSGHYKPEKGGV------------KTKLKLGN---NFM 238
                                     :..:|...|.:.|:            :|..|:..   ||:
  Rat   350 ASVRRASSADDIEAMRAGALPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFV 414

  Fly   239 HSTEAPF-------------------------------------PEYKTQSIKKSRLILPHYGVF 266
            .....||                                     ||||.|:.:..|..:.||..|
  Rat   415 DLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPF 479

  Fly   267 KGIWDWVILVATFYVALMVPYNAAF--------------AKADRQTKVSDVIVEALFIVDILLNF 317
            |.:|||:||:...|.|:..||:|||              ..|.:...|.|::|:.:||||||:||
  Rat   480 KAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINF 544

  Fly   318 RTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLA 382
            |||:|:...||||:..:||::|.:|||.:|::||:|||.|...   .|.:..|.|:|..|||||.
  Rat   545 RTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFG---SGSEELIGLLKTARLLRLV 606

  Fly   383 RLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFPESNIGWLQLLAER----- 442
            |:.:|:||||::.|.:|.|||.:|.|.|||||||||.|...|.... :|:||||..|.::
  Rat   607 RVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHM-DSHIGWLHNLGDQIGKPY 670

  Fly   443 KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAI 507
            .::.:...:..:.|.|||||||:|||||||||||.||.:||:|:|.:||||:||:|.:||||:||
  Rat   671 NSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 735

  Fly   508 IQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGD 572
            |||:||..:.|.::...:::|:..|.:|..|:||:|:|||.:||.::|||:...|:.|||.|:.|
  Rat   736 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQAD 800

  Fly   573 VSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKD 636
            :.:||:|.:|| ...|..|::|||:.|::..||....||:.|:|.||.|..:|::..||:|:::.
  Rat   801 ICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 865

  Fly   637 DMVVAILGKGDLVGSDINVHL-VATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGL 700
            |:|||||||.|:.|..:|::. ...|||                   |::|||||||..||...|
  Rat   866 DVVVAILGKNDIFGEPLNLYARPGKSNG-------------------DVRALTYCDLHKIHRDDL 911

  Fly   701 VEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENRE----------- 754
            :|||.:|||:...|.:.:  ::|.|||      |:::.|..|..:..|...||:
  Rat   912 LEVLDMYPEFSDHFWSSL--EITFNLR------DTNMIPGSPSSAELESGFNRQRKRKLSFRRRT 968

  Fly   755 --------EAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSPLLGMGSPRNQRLHQRGRSLI 811
                    |....|:|....|.||.....|     ..|.  ..||..|..||.:......|||..
  Rat   969 DKDTEQPGEVSALGQGPARVGPGPSCRGQP-----GGPW--GESPSSGPSSPESSEDEGPGRSSS 1026

  Fly   812 TLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTLHQDVAQLSAEVRN 876
            .||..                .|..|.|  ...|.||: |..|  |.:.|:   |.....:...:
  Rat  1027 PLRLV----------------PFSSPRP--PGDSPGGE-PLTE--DGEKSS---DTCNPLSGAFS 1067

  Fly   877 AISALQEMTFTSNAMTSHSSLKFP-PARSIPNIS-GVAGTRSGVAVEHGL-------------MG 926
            .:|.:......|.........:.| ||.|:.||. ...|.||...||..|             :.
  Rat  1068 GVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLS 1132

  Fly   927 GVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRS-SQTDFYRIDFPT 990
            ..:|.. |..:||..:..|..:.. |..|.....|:....||.|..|:|..| ||..    .|..
  Rat  1133 ADMATV-LQLLQRQMTLVPPAYSA-VTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVS----QFVA 1191

  Fly   991 FERFVLANPRL-------------VLGLLGIEPAIKNEMD 1017
            ||......|.|             .||.|..:|..::..|
  Rat  1192 FEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSD 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	41/95 (43%)
		PAS_3	41..129	CDD:285623	41/87 (47%)
		Ion_trans	285..516	CDD:278921	120/249 (48%)
		Ion_trans_2	<455..510	CDD:285168	39/54 (72%)
		Crp	583..>650	CDD:223736	29/67 (43%)
		CAP_ED	586..715	CDD:237999	50/129 (39%)
Kcnh2	XP_006235929.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750