Protein Alignment Elk and Kcnh6

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_006247617.1
• Gene: Kcnh6 / 116745
• RGDID: 620304
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 1039
• Identity: 362/1039 - (34%)
• Similarity: 538/1039 - (51%)
• Gaps: 168/1039 - (16%)

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:|||||:||||..:|:|....|::.|||.....|:||:|||.:|.||||.::||:.|:
  Rat     1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||.||:|......::.::|....|.|:::::|:|:.:.|.||.|:||:|||...|::|:.:.:
  Rat    66 CDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFE 130

  Fly   131 DITHTKMLEMNVNEECDSVFALTAALLGARF--RAGSNAGMLGLGGLPGLGG-------PAASDG 186
            |:  .::|..:      |..:||..||...|  ..||::...|.|..||.|.       |..:..
  Rat   131 DL--AQLLAKS------SSRSLTQRLLSHSFLGSEGSHSRPSGQGPGPGRGKYRTVSQIPQFTLN 187

  Fly   187 DTE-------AGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAP 244
            ..|       :|....:::.|...:..|.....          ||  |...|.||.:.:
  Rat   188 FVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVT----------EK--VTQVLSLGADVL------ 234

  Fly   245 FPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK---------- 299
             ||||.|:.:..|..:.||..||.:|||:||:...|.|:..||:|||..:|:...
  Rat   235 -PEYKLQAPRIHRGTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGTCGYTCS 298

  Fly   300 ---VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASD 361
               |.|:||:.:|:|||::|||||:|:...||||:.::||::|.:|||.:|::||:|||.|....
  Rat   299 PLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRT 363

  Fly   362 LYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE 426
            ..|...:.|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.|||||||||.|...|..
  Rat   364 GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERP 428

  Fly   427 WFPESNIGWLQ----LLAERKNAS--VAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVF 485
            :. |..||||.    .|.::.|.|  .:..:..:.|.|||||||:|||||||||||.||.:||||
  Rat   429 YL-EPKIGWLDSLGAQLGKQYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVF 492

  Fly   486 TIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSW 550
            :|.:||||:||:|.:||||:|||||:||..:.|.::...:|:|:..|.:|..|:||:|:|||.:|
  Rat   493 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 557

  Fly   551 SLSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTNFCAPGEYLI 614
            |.::|||:...|:.|||.|:.|:.:||||.:|| .|.|..||:|||:.|::..||....||:.|:
  Rat   558 SYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLV 622

  Fly   615 HKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVR 679
            |.||.|:.:|::..||:|:::||:|||||||.|:.|...::|.             ..|     :
  Rat   623 HLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPASLHA-------------RPG-----K 669

  Fly   680 SSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLP 744
            ||:|::|||||||..||...|:|||.:||.:...|.|.:  ::|.|||:           |.||.
  Rat   670 SSADVRALTYCDLHKIHRADLLEVLDMYPAFADTFWNKL--EVTFNLRD-----------SCPLH 721

  Fly   745 SI------------SEDDENREEAEEGGKGEKENGG----GPPSGASPLHNISNS----PLHATR 789
            .|            :.:|...:.......|.::..|    ...|||:|..:||::    |....:
  Rat   722 VILLMAIILMNKPTTREDGGLQSTPRQAPGHQDPQGFFLNDSQSGAAPSLSISDTSALWPELLQQ 786

  Fly   790 SPLLGMGSPRN-----------------------QRLHQR-----GRSLITLRETNKR-HRTLNA 825
            .|    .||.|                       .||..|     .|.|..|:....| ...|.|
  Rat   787 MP----PSPPNPRQDLDCWPRELGFKLEQLQAQMNRLESRVSSDLSRILQLLQHPQGRPSYILGA 847

  Fly   826 ACSLDRGSFEEPEPLEEEQSS--GGKRPSLER-----LDSQVSTLHQDVAQLSAEVRNAISALQE 883
            :.|.|..||.|.......:|:  .|..||.:.     ||..:.|    ....|....:...|:.:
  Rat   848 SASSDLASFPETSVTRSSESTLLVGHVPSAQTLSYGDLDDHIQT----PRNFSPRTPHVAMAMDK 908

  Fly   884 MTFTSNAMTSHSSLKFP---PARSIPNISGVAGTRSGVAVEHGLMGGVLAAAELAAMQRSSSHP 944
            ....|:.......|..|   |.|.: .:.|:.|:|.....||     :.:..:....||..|.|
  Rat   909 TLVPSSEQEQPGGLLSPLASPLRPL-EVQGLGGSRVPSLPEH-----LSSVPKQLEFQRHGSDP 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	37/92 (40%)
		PLN03192	270..>650	CDD:215625	189/399 (47%)
		cNMP	586..716	CDD:197516	52/129 (40%)
Kcnh6	XP_006247617.1	PAS_9	38..132	CDD:463873	36/93 (39%)
		PLN03192	259..>698	CDD:215625	208/457 (46%)