DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh6

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_006247617.1	Gene:	Kcnh6 / 116745	RGDID:	620304	Length:	971	Species:	Rattus norvegicus

Alignment Length:	1039	Identity:	362/1039 - (34%)
Similarity:	538/1039 - (51%)	Gaps:	168/1039 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:|||||:||||..:|:|....|::.|||.....|:||:|||.:|.||||.::||:.|:
  Rat     1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||.||:|......::.::|....|.|:::::|:|:.:.|.||.|:||:|||...|::|:.:.:
  Rat    66 CDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFE 130

  Fly   131 DITHTKMLEMNVNEECDSVFALTAALLGARF--RAGSNAGMLGLGGLPGLGG-------PAASDG 186
            |:  .::|..:      |..:||..||...|  ..||::...|.|..||.|.       |..:..
  Rat   131 DL--AQLLAKS------SSRSLTQRLLSHSFLGSEGSHSRPSGQGPGPGRGKYRTVSQIPQFTLN 187

  Fly   187 DTE-------AGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAP 244
            ..|       :|....:::.|...:..|.....          ||  |...|.||.:.:
  Rat   188 FVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVT----------EK--VTQVLSLGADVL------ 234

  Fly   245 FPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK---------- 299
             ||||.|:.:..|..:.||..||.:|||:||:...|.|:..||:|||..:|:...
  Rat   235 -PEYKLQAPRIHRGTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGTCGYTCS 298

  Fly   300 ---VSDVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASD 361
               |.|:||:.:|:|||::|||||:|:...||||:.::||::|.:|||.:|::||:|||.|....
  Rat   299 PLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRT 363

  Fly   362 LYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE 426
            ..|...:.|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.|||||||||.|...|..
  Rat   364 GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERP 428

  Fly   427 WFPESNIGWLQ----LLAERKNAS--VAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVF 485
            :. |..||||.    .|.::.|.|  .:..:..:.|.|||||||:|||||||||||.||.:||||
  Rat   429 YL-EPKIGWLDSLGAQLGKQYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVF 492

  Fly   486 TIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSW 550
            :|.:||||:||:|.:||||:|||||:||..:.|.::...:|:|:..|.:|..|:||:|:|||.:|
  Rat   493 SICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 557

  Fly   551 SLSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIKTNFCAPGEYLI 614
            |.::|||:...|:.|||.|:.|:.:||||.:|| .|.|..||:|||:.|::..||....||:.|:
  Rat   558 SYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLV 622

  Fly   615 HKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVR 679
            |.||.|:.:|::..||:|:::||:|||||||.|:.|...::|.             ..|     :
  Rat   623 HLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPASLHA-------------RPG-----K 669

  Fly   680 SSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLP 744
            ||:|::|||||||..||...|:|||.:||.:...|.|.:  ::|.|||:           |.||.
  Rat   670 SSADVRALTYCDLHKIHRADLLEVLDMYPAFADTFWNKL--EVTFNLRD-----------SCPLH 721

  Fly   745 SI------------SEDDENREEAEEGGKGEKENGG----GPPSGASPLHNISNS----PLHATR 789
            .|            :.:|...:.......|.::..|    ...|||:|..:||::    |....:
  Rat   722 VILLMAIILMNKPTTREDGGLQSTPRQAPGHQDPQGFFLNDSQSGAAPSLSISDTSALWPELLQQ 786

  Fly   790 SPLLGMGSPRN-----------------------QRLHQR-----GRSLITLRETNKR-HRTLNA 825
            .|    .||.|                       .||..|     .|.|..|:....| ...|.|
  Rat   787 MP----PSPPNPRQDLDCWPRELGFKLEQLQAQMNRLESRVSSDLSRILQLLQHPQGRPSYILGA 847

  Fly   826 ACSLDRGSFEEPEPLEEEQSS--GGKRPSLER-----LDSQVSTLHQDVAQLSAEVRNAISALQE 883
            :.|.|..||.|.......:|:  .|..||.:.     ||..:.|    ....|....:...|:.:
  Rat   848 SASSDLASFPETSVTRSSESTLLVGHVPSAQTLSYGDLDDHIQT----PRNFSPRTPHVAMAMDK 908

  Fly   884 MTFTSNAMTSHSSLKFP---PARSIPNISGVAGTRSGVAVEHGLMGGVLAAAELAAMQRSSSHP 944
            ....|:.......|..|   |.|.: .:.|:.|:|.....||     :.:..:....||..|.|
  Rat   909 TLVPSSEQEQPGGLLSPLASPLRPL-EVQGLGGSRVPSLPEH-----LSSVPKQLEFQRHGSDP 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	36/95 (38%)
		PAS_3	41..129	CDD:285623	36/87 (41%)
		Ion_trans	285..516	CDD:278921	122/249 (49%)
		Ion_trans_2	<455..510	CDD:285168	40/54 (74%)
		Crp	583..>650	CDD:223736	32/67 (48%)
		CAP_ED	586..715	CDD:237999	51/128 (40%)
Kcnh6	XP_006247617.1	PAS_9	29..132	CDD:290162	40/102 (39%)
		PAS	41..132	CDD:238075	36/90 (40%)
		Ion_trans	296..520	CDD:278921	114/224 (51%)
		Ion_trans_2	<463..517	CDD:285168	40/53 (75%)
		Crp	588..>701	CDD:223736	54/130 (42%)
		CAP_ED	594..705	CDD:237999	51/128 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820