Protein Alignment Elk and Hcn3

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: NP_446137.1
• Gene: Hcn3 / 114245
• RGDID: 620691
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 887
• Identity: 203/887 - (22%)
• Similarity: 345/887 - (38%)
• Gaps: 217/887 - (24%)

  Fly   181 PAASDGD--TEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLG-------NN 236
            ||..||:  |.|.|    ..||.....|..|..|         ||......:.:||       |.
  Rat     7 PAVGDGEAATPARE----TPPAAPAQARAASGGV---------PESAPEPKRRQLGTLLQPTVNK 58

  Fly   237 FMHSTEAPFPEYKTQSIKKSRL------ILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD 295
            |   :...|..:|...|::.|:      |:..|..|:..||.::|:......:::|....|.|.:
  Rat    59 F---SLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEE 120

  Fly   296 RQTK--VSDVIVEALFIVDILLNFRTTFVSRKG-EVVSNSKQIAINYLRGWFALDLLAALPFDHL 357
            ....  |.:|:.:..|::|::|||||..|..:| |::...:.|...|||.||.:||::::|.|::
  Rat   121 NSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYI 185

  Fly   358 Y-ASDLYDGEDSHIH-------------LVKLTRLLRLARLLQKIDRYSQHTAMILTL------- 401
            : ..:|....|:.::             ::.|.|||||:||::.:.::.:...|...|
  Rat   186 FLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYMHQWEEIFHMTYDLASAVVRI 250

  Fly   402 --LMFSFTLAAHWLACIWYVIAVKEYEWFPES---------NIGWLQLLAERKNASVAILTTAET 455
              |:....|..||..|:.:::.:  .:.||..         |..|                 ...
  Rat   251 FNLIGMMLLLCHWDGCLQFLVPM--LQDFPSDCWVSMNRMVNHSW-----------------GRQ 296

  Fly   456 YSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYES 520
            ||.||:...:.:..:|:|..:.....:...|::.|::||..:|:..|:.||:||.:.|.|..|:.
  Rat   297 YSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 361

  Fly   521 KWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEE-LRGDVSMHLHREIL-- 582
            |::.::.:::.|.:|.:.:|||.:|::..:   .|       :.|.|| :.|::|..|..||:
  Rat   362 KYKQVEQYMSFHKLPADTRQRIHEYYEHRY---QG-------KMFDEESILGELSEPLREEIINF 416

  Fly   583 -------QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVV 640
                   .:|:|..|....:..:...::.....||:.::.:|.....:|::.:|.:.|:......
  Rat   417 TCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD 481

  Fly   641 AILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLR 705
            ..|..|...|     .:...:.|:.||:               ::|.|||.|..:.:.....||.
  Rat   482 TRLTDGSYFG-----EICLLTRGRRTAS---------------VRADTYCRLYSLSVDHFNAVLE 526

  Fly   706 LYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKE----- 765
            .:|..::.|.......|.   |.|.:|.......|.|.|..|          .||..|:.
  Rat   527 EFPMMRRAFETVAMDRLR---RIGKKNSILQRKRSEPSPGSS----------SGGVMEQHLVQHD 578

  Fly   766 -------NGGGPPSGASPLHNISNSP------LHATRSPLLGMGSPRNQRL---HQRGRSLITLR 814
                   .|..|.:||    .:|..|      :||   ||.......|..:   ||||    .|.
  Rat   579 RDMARGIRGLAPGTGA----RLSGKPVLWEPLVHA---PLQAAAVTSNVAIALTHQRG----PLP 632

  Fly   815 ETNKRHRTLNAACSLDRGSFEEPEPLEEEQS----SGGKRPSLERLDS-QVSTLHQDVAQLSAEV 874
            .:.....|| .|.|..|.:.....||...::    :.|...|..||.: ...|||   |.||...
  Rat   633 LSPDSPATL-LARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPARTLH---ASLSRTG 693

  Fly   875 RNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVEHGLMGGVLAAAELAAMQR 939
            |:.:|.|.                 ||       .|..|.|.|.      .|..|:|::.:..||
  Rat   694 RSQVSLLG-----------------PP-------PGGGGRRLGP------RGRPLSASQPSLPQR 728

  Fly   940 SS--SHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSS 979
            ::  ..|........:||.|... :|.|..|:|     ||||
  Rat   729 ATGDGSPRRKGSGSERLPPSGLL-AKPPGTVQP-----SRSS 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873
		PLN03192	270..>650	CDD:215625	95/424 (22%)
		cNMP	586..716	CDD:197516	23/129 (18%)
Hcn3	NP_446137.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		14/52 (27%)
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		10/47 (21%)
		Ion_trans_N	48..90	CDD:400630	10/44 (23%)
		Ion_trans	92..357	CDD:459842	66/283 (23%)
		Interaction with KCTD3. /evidence=ECO:0000250|UniProtKB:O88705	353..780		113/506 (22%)
		CAP_ED	427..535	CDD:237999	22/127 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..569		6/29 (21%)
		PHA03307	589..>772	CDD:223039	58/227 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..780		29/114 (25%)