DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Hcn2

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_446136.1	Gene:	Hcn2 / 114244	RGDID:	620689	Length:	863	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	204/919 - (22%)
Similarity:	354/919 - (38%)	Gaps:	260/919 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 GPAASD--GDTEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTE 242
            ||||::  |..|||       |||...|.:.| .:..|.....:|   ||.   |.......|.:
  Rat   110 GPAAAEEAGSEEAG-------PAGEPRGSQAS-FLQRQFGALLQP---GVN---KFSLRMFGSQK 160

  Fly   243 APFPEYKTQSIKKSRLILPH-YGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK---VSDV 303
            |  .|.:.:.:|.:...:.| |..|:..||:.:|:......:::|....|.| |..|.   |.:|
  Rat   161 A--VEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFK-DETTAPWIVFNV 222

  Fly   304 IVEALFIVDILLNFRTTFVSRKG-EVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGED 367
            :.:..|::|::|||||..|.... |::.:.::|...|||.||.:|.::::|.|:::.. :..|.|
  Rat   223 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLI-VEKGID 286

  Fly   368 SHIH-------------LVKLTRLLRLARLLQKIDRYSQ---------HTAMILTLLMFSFTLAA 410
            |.::             ::.|.|||||:||::.|.::.:         ...|.:..|:....|..
  Rat   287 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLC 351

  Fly   411 HWLACIWYVIAVKEYEWFPES---------NIGWLQLLAERKNASVAILTTAETYSTALYFTFTS 466
            ||..|:.:::.:  .:.||..         |..|                 :|.||.||:...:.
  Rat   352 HWDGCLQFLVPM--LQDFPSDCWVSINNMVNHSW-----------------SELYSFALFKAMSH 397

  Fly   467 LTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVAL 531
            :..:|:|..:..:..:...|::.|::||..:|:..|:.||:||.:.|.|..|:.|::.::.:::.
  Rat   398 MLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSF 462

  Fly   532 HNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGD-VSMHLHREILQLPIFEAASQGCL 595
            |.:|.:.:|:|.||::..:. ....|....|.|....||.: |:.:..:.:..:|:|..|....:
  Rat   463 HKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFV 526

  Fly   596 KLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVAT 660
            ..:...:|.....||:|:|.:|.....:|::.:|         ||::|.||
  Rat   527 TAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHG---------VVSVLTKG-------------- 568

  Fly   661 SNGQMTATTNSAGQDVVV----RSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQF------- 714
             |.:|..:..|...::.:    |.::.::|.|||.|..:.:....|||..||..::.|
  Rat   569 -NKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDR 632

  Fly   715 -----------ANDIQHDLTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGG 768
                       .:.:||||:..:   :.||::.|     :..|.:.|  ||..::...|::....
  Rat   633 LDRIGKKNSILLHKVQHDLSSGV---FNNQENAI-----IQEIVKYD--REMVQQAELGQRVGLF 687

  Fly   769 GPP------SGASPLHN-ISNSPLHATRSPLLG---MGSPRNQRLHQRGRSLITLRETNKRHRTL 823
            .||      |..:.|.. ::.|.......||:|   :|||   ||.:|.
  Rat   688 PPPPPPQVTSAIATLQQAVAMSFCPQVARPLVGPLALGSP---RLVRRA---------------- 733

  Fly   824 NAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTLHQDVAQLSAEVRNAISALQEMTFTS 888
                        .|.||....|.|
  Rat   734 ------------PPGPLPPAASPG----------------------------------------- 745

  Fly   889 NAMTSHSSLKFPPARSIP--------------NISGVAGTRSGVAVEHGLMGGVLAAAELAAMQR 939
                       |||.|.|              .:.|...||.|.|         |.|..|:...|
  Rat   746 -----------PPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPA---------LPARRLSRASR 790

  Fly   940 --SSSHPPEVWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRIDFPTFERFVLANPRLV 1002
              |:|.|        .||....|.|.|.| ..|..:.|.|.......|...|:.:|...|:|...
  Rat   791 PLSASQP--------SLPHGAPAPSPAAS-ARPASSSTPRLGPAPTTRTAAPSPDRRDSASPGAA 846

  Fly  1003 LGLLGIEPA 1011
            .||..::.|
  Rat   847 SGLDPLDSA 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	65/265 (25%)
		Ion_trans_2	<455..510	CDD:285168	15/54 (28%)
		Crp	583..>650	CDD:223736	16/66 (24%)
		CAP_ED	586..715	CDD:237999	30/150 (20%)
Hcn2	NP_446136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		11/27 (41%)
		Involved in subunit assembly. /evidence=ECO:0000250	131..182		12/59 (20%)
		Ion_trans_N	140..182	CDD:285597	10/49 (20%)
		Ion_trans	202..447	CDD:278921	65/265 (25%)
		Crp	511..>646	CDD:223736	31/158 (20%)
		CAP_ED	517..625	CDD:237999	29/131 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..863		40/224 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810