DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and Kcnh4

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_446082.2	Gene:	Kcnh4 / 114032	RGDID:	621415	Length:	1016	Species:	Rattus norvegicus

Alignment Length:	1091	Identity:	469/1091 - (42%)
Similarity:	621/1091 - (56%)	Gaps:	183/1091 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQA-NGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||||||||||||:|.|||. .|.|||||||||.:||||.|.::|||.|
  Rat     1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGPRGFPIVYCSDGFCELTGYGRTEVMQKTC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            ||.|||||:|.|...|:::|:|....|.:.|:.||:|:|:.||||.|::|||||..:|||||.|.
  Rat    66 SCRFLYGPETSEPALQRLQKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            |||:.:                                     || ||||.|.....:.......
  Rat   131 KDISQS-------------------------------------GG-PGLGSPGIHGDNNHENSLG 157

  Fly   195 NLDVPAGCNMGRRRSRAVLYQLSGHY-KPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRL 258
            .....:.....||::|.||::|:||: :.::|.||     .|:.:...:...||||..|:..||.
  Rat   158 RRGASSRLRSTRRQNRTVLHRLTGHFGRRDQGSVK-----ANSNVFEPKPSVPEYKVASVGGSRC 217

  Fly   259 ILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD------RQTKVSDVIVEALFIVDILLNF 317
            :|.||.:.|.:||.:||:||||||:.||||..||..|      |.|.|||:.||.|||:||:|||
  Rat   218 LLLHYSIPKAVWDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAVEMLFILDIILNF 282

  Fly   318 RTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLA 382
            |||:||:.|:|||..:.|.::||..||.:||:||||||.||..::  ...|.:||:|..|||||.
  Rat   283 RTTYVSQSGQVVSAPRSIGLHYLATWFFVDLIAALPFDLLYVFNI--TVTSLVHLLKTVRLLRLL 345

  Fly   383 RLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWLQLLAE 441
            |||||::||||.:|::|||||..|.|.|||:||:||||..:|.|      |    :||||..|.:
  Rat   346 RLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEANDPLLW----DIGWLHELGK 406

  Fly   442 R-----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVF 501
            |     .|.|....:....|..|||||.:||||||||||.|||.|||:|:|..||||||||||||
  Rat   407 RLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVF 471

  Fly   502 GNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFP 566
            |||||||||||||||||.|:.:|||||:.:|.:|:.||||:.:||||:|:::.|||..|.||:||
  Rat   472 GNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFP 536

  Fly   567 EELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSM 631
            :|||.|::|||:|||||||:|.|||:|||:.|||||||:||||||:|:.:||||...||:|:||:
  Rat   537 DELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEFLLRRGDALQAHYYVCSGSL 601

  Fly   632 EVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIH 696
            ||::|:.|:||||||||:|:||      ...||    ...||...|:::|:|:||||||.|:.:.
  Rat   602 EVLRDNTVLAILGKGDLIGADI------PELGQ----EPGAGAGCVLKTSADVKALTYCGLQQLS 656

  Fly   697 MGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYEN---------------QDSDIGPSF--PLP 744
            ..||.|||||||||...|...:..|||.|||:|.||               :...:|.|.  .||
  Rat   657 SRGLAEVLRLYPEYVAAFRAGLPRDLTFNLRQGSENNGLGRFSRSPRLSQARSDTLGSSSDKTLP 721

  Fly   745 SISEDDENREEAEEGGKGEKEN--------GGGPPSGA---------SPLHNISNSP-LHATRSP 791
            ||:|    .|...|.|.|.|..        ....|.|:         .|...:.:|| |..|.||
  Rat   722 SITE----TEGGMEPGAGSKPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSP 782

  Fly   792 -LLGMGSPRNQRLHQRGRS-----------LITLRETNKRHRTL----NAACSLDRGSF---EEP 837
             |.|.||..:.....||.:           |.|....:...|.:    :::.:.:..:|   :.|
  Rat   783 ALAGRGSSPSLHGPPRGSAAWKPPQLLTPPLGTFGPPDLSPRIVDGIEDSSNTAEAPTFRFSKRP 847

  Fly   838 EPLEEEQSS--GGKRPSLE--------------RLDSQVSTLHQDVAQLSAEVRNAISALQ---- 882
            ||......:  .|.|.|.|              ||:.::|.|:|:|:|||.|:|..:..||
  Rat   848 EPTRTRSQAPLSGPRLSRELATEAAEEVKEKVCRLNQEISRLNQEVSQLSRELRQVMGLLQARLG 912

  Fly   883 ------EMTFTSNAMTSHSSLKFPPARSIPNISGVAG--TRSGVAVEH--GLMGGVLAAAELAAM 937
                  :.|:..:....|..   ||..| |::||...  ..:.:||.|  ..:|.|...|..:.:
  Rat   913 PPSHPPDSTWLPDLPCPHQR---PPCIS-PHMSGPPPGLQNTTLAVVHCPASVGTVEIGATPSEL 973

  Fly   938 QRSSSHPPEVWGRDVQLPTSNTASSKAP----SPVEPKKTMTSRSSQTDFY 984
             |||..||        .|:.......:|    ||:.|.....|..|.:|.:
  Rat   974 -RSSMVPP--------FPSEPDPLGPSPVPEASPLTPSLLKHSFQSGSDTF 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	54/96 (56%)
		PAS_3	41..129	CDD:285623	50/87 (57%)
		Ion_trans	285..516	CDD:278921	141/247 (57%)
		Ion_trans_2	<455..510	CDD:285168	43/54 (80%)
		Crp	583..>650	CDD:223736	45/66 (68%)
		CAP_ED	586..715	CDD:237999	70/128 (55%)
Kcnh4	NP_446082.2	PRK13559	41..>134	CDD:237427	54/92 (59%)
		PLN03192	177..>620	CDD:215625	254/453 (56%)
		Selectivity filter. /evidence=ECO:0000250	439..444		4/4 (100%)
		CAP_ED	578..667	CDD:412130	49/98 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..748		15/62 (24%)
		PHA03247	<732..1007	CDD:223021	66/287 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..869		23/98 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..1016		13/54 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338755
Domainoid	1	1.000	278	1.000	Domainoid score	I1632
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	786	1.000	Inparanoid score	I494
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm44457
orthoMCL	1	0.900	-	-		OOG6_104228
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760