DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and hcn1

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_031750156.1	Gene:	hcn1 / 100490760	XenbaseID:	XB-GENE-950265	Length:	839	Species:	Xenopus tropicalis

Alignment Length:	825	Identity:	184/825 - (22%)
Similarity:	338/825 - (40%)	Gaps:	178/825 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 EYKTQSIKKSRLILPH-YGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQTK--VSDVIVEAL 308
            |.:.:.:|.:.:.:.| |..|:..||.::|:......:::|....|......|.  :.:|..:.:
Frog    96 EKEQERVKTAGVWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTV 160

  Fly   309 FIVDILLNFRTTFV-SRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIH- 371
            |:.|:.:||||..| ....|::.:.|.|.:|||:.||.:|.::::|.|:::.. :..|.||.::
Frog   161 FLFDLFMNFRTGIVIEDNSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLI-VEKGMDSEVYK 224

  Fly   372 ------------LVKLTRLLRLARLLQKIDRYSQHTAMILTL---------LMFSFTLAAHWLAC 415
                        ::.|.|||||:||::.|.::.:...|...|         |:....|..||..|
Frog   225 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGC 289

  Fly   416 IWYVIAVKEYEWFPESNIGWLQLLAERKNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTT 480
            :.:::.:.: |:.|:.   |:.|      .::...:..:.||.||:...:.:..:|:|..:..:.
Frog   290 LQFLVPLLQ-EFPPDC---WVSL------NNMVNDSWGKQYSYALFKAMSHMLCIGYGARAPVSM 344

  Fly   481 AEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDY 545
            ::...|::.|::||..:|:..|:.||:||.:.|.|..|:.|::.::.:::.|.:|.:::|:|.||
Frog   345 SDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPSDMRQKIHDY 409

  Fly   546 FQTSWSLSHGIDIYETLREFPEELRGD-VSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAP 609
            ::..:. ....|....|.|..:.||.: |:.:..:.:..:|:|..|....:..:...:|.....|
Frog   410 YEHRYQ-GKIFDEDNILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLKFEVFQP 473

  Fly   610 GEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQ 674
            |:|:|.:|.....:|::.:|...||........|..|...|     .:...:.|:.||:
Frog   474 GDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFG-----EICLLTKGRRTAS------ 527

  Fly   675 DVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQF-------------ANDI-----QHD 721
                     ::|.|||.|..:.:....|||..||..::.|             .|.|     |.|
Frog   528 ---------VRAETYCRLYSLSVENFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILQQRFQKD 583

  Fly   722 LTCNLREGYENQDSDIGPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLH 786
            |...:   :.||:|:|     |..:...|  ||..|           |.||       :|...|.
Frog   584 LNTGI---FNNQESEI-----LKQMLTQD--REMVE-----------GHPS-------VSYQQLP 620

  Fly   787 ATRSPLLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQ------- 844
            |       :.|..:..|..|.||           ..:..|.||..|:.:.|.|..:..
Frog   621 A-------LNSSTSSSLRMRTRS-----------PPVYNANSLSHGNLQSPTPSPQTPQQAVVFS 667

  Fly   845 ----SSGGKRPSLERLDSQVSTLHQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPA--- 902
                :|....||::      |.|.....|.|:...:.:|.:|:....|.|...|...|...|
Frog   668 PSSFTSAACSPSVQ------SPLAGRTFQYSSLTASQLSLIQQQQQASGASQIHEVHKSAQALAN 726

  Fly   903 --------------RSIPNISGVAGTRSGVAVEHGLMGGVLA----------AAELAAMQRSSSH 943
                          .|:|:.....|::     .|..:|..||          ||...:..||:..
Frog   727 TNLTREVRPLSASQPSLPHEISTLGSK-----PHPTVGESLASLPQPISNVQAAGTQSGSRSNIP 786

  Fly   944 PPEVWGRDVQ---LPTSNTASSKAPSPVEPKK---TMTSRSSQTD 982
            |.....|.:.   ||.:...::..|||..|.|   |::|..:.||
Frog   787 PRVALFRQMSSGALPPARVGATTQPSPAPPTKDSSTVSSTDTDTD 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075
		PAS_3	41..129	CDD:285623
		Ion_trans	285..516	CDD:278921	62/255 (24%)
		Ion_trans_2	<455..510	CDD:285168	15/54 (28%)
		Crp	583..>650	CDD:223736	15/66 (23%)
		CAP_ED	586..715	CDD:237999	29/141 (21%)
hcn1	XP_031750156.1	Ion_trans_N	73..115	CDD:400630	4/18 (22%)
		PLN03192	108..>587	CDD:215625	118/510 (23%)
		CAP_ED	450..558	CDD:237999	28/127 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910