Protein Alignment Elk and kcnh6

DIOPT Version :10

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_012808358.2
• Gene: kcnh6 / 100485121
• XenbaseID: XB-GENE-990943
• Length: 1063
• Species: Xenopus tropicalis
• Alignment Length: 1236
• Identity: 389/1236 - (31%)
• Similarity: 588/1236 - (47%)
• Gaps: 293/1236 - (23%)

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGCS 65
            ||.|:|.:|||||:||||..:|:|....|::.|||.:...|:||:|||.|:.||||.::||:.|:
 Frog     1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMDNCAIIYCNDGFCDMFGYSRVEVMQRPCT 65

  Fly    66 CHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHK 130
            |.||.||:|......|:.::|....|.|||:::|:|||:...||.|:||:|||:.||::|:.:.:
 Frog    66 CDFLTGPETTSNSITQLTEALLGSEERKLEILYYRKEGSCLRCLVDVVPVKNEEGDVIMFILNFE 130

  Fly   131 DITHTKMLEMNVNEECDSVFALTAALLGARF---RAGSNAGMLGLGGLPGLGGPAASDGD----- 187
            |:  ..:|....|.      .|...|..|.|   |..:.|..|.          ::|:.|
 Frog   131 DL--ALLLARKANR------TLHQRLTRAAFHSERPKTKANFLN----------SSSESDFMKYR 177

  Fly   188 -------------------TEAGEGNNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKL 233
                               ..:.....:::.|..|...|.....          ||  |...|.|
 Frog   178 TISQIPQFTLNFVEFNLEKHRSASTTEIEIVAPSNAFERTQNVT----------EK--VTQVLSL 230

  Fly   234 GNNFMHSTEAPFPEYKTQSIKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKADRQT 298
            |.:.:       ||||.|:.:..|..:.||..||.:|||:||:...|.|:..||:|||...|::.
 Frog   231 GADVL-------PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLNDQEE 288

  Fly   299 KVS-------------DVIVEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLA 350
            :.|             |:||:.:|||||::|||||:|:...||||:..:|||:|.:|||.:|::|
 Frog   289 ESSWECGYSCNPLNIVDLIVDIMFIVDIIINFRTTYVNINDEVVSHPAKIAIHYFKGWFLIDMVA 353

  Fly   351 ALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLAC 415
            |:|||.|......|...:.|.|:|..|||||.|:.:|:||||::.|.:|.|||.:|.|.||||||
 Frog   354 AIPFDLLIYRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLAC 418

  Fly   416 IWYVIAVKEYEWFPESNIGWLQLLAER--KNASVAILTTA----ETYSTALYFTFTSLTSVGFGN 474
            |||.|...|.. ..:..||||..||.:  |:.:...||:.    :.|.|||||||:|||||||||
 Frog   419 IWYAIGNVERP-LMQHKIGWLDNLAAQIGKSYNDTDLTSGPSIKDKYVTALYFTFSSLTSVGFGN 482

  Fly   475 VSANTTAEKVFTIIMMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELK 539
            ||.||.:||:|:|.:||||:||:|.:||||:|||||:||..:.|.::...:|:|:..|.:|..|:
 Frog   483 VSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLR 547

  Fly   540 QRIEDYFQTSWSLSHGIDIYETLREFPEELRGDVSMHLHREILQ-LPIFEAASQGCLKLLSLHIK 603
            ||:|:|||.:||.::|||:...|:.|||.|:.|:.:||:|.:|| ...|..|::|||:.|::..:
 Frog   548 QRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRTLLQHCKAFRGATKGCLRALAMKFR 612

  Fly   604 TNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTAT 668
            |....||:.|:|.||.|..:|::..||:|:::||:|||||||.|:.|..||  |.|...
 Frog   613 TTHAPPGDTLVHYGDVLTNLYFISRGSIEILRDDIVVAILGKNDIFGEPIN--LFARPG------ 669

  Fly   669 TNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQ 733
                      :|::|::|||||||..|....|:|||.:||.:...|.:::  ::|.|||
 Frog   670 ----------KSNADVRALTYCDLHKIQREDLLEVLDMYPTFSDNFWSNL--EITFNLR------ 716

  Fly   734 DSDIGPSFPLPSISEDDE-------NREEAEEGGKGEKENGGGPPSGASPLHNISNSPLHATRSP 791
            |:|..|..|     |.:|       || ..::.|:.:|:|     .|...::  |::..:.|.|.
 Frog   717 DADSIPRSP-----ESEEYNCTYRRNR-RCKQPGRRQKKN-----EGVDEIN--SDAEQYHTYSE 768

  Fly   792 LLGMGSPRNQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERL 856
            |..:..|             |.||..:...:....||  :.|.||.:||
 Frog   769 LTNLQRP-------------TSREHWEEMASSTTPCS--QTSDEETKPL---------------- 802

  Fly   857 DSQVSTLHQDVAQLSAEVRNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGVAGTRSGVAVE 921
                ::...|: |.:||.:..|.|:      .|.:|:             |||...|.|.
 Frog   803 ----NSAPVDI-QAAAEKQEFIPAV------VNLVTA-------------NISSREGGRK----- 838

  Fly   922 HGLMGGVLAAAELAAMQRSSSHPPEV------WGRDVQLPTSNT------ASSKAPSPVEPKKTM 974
                       .|.:::..|:.|.||      ||.......|.|      ..:....|:.|....
 Frog   839 -----------VLNSVETYSAAPIEVPNLFSFWGERHSAGCSETHQHISLVHNSLEPPLSPDDRP 892

  Fly   975 TSRSSQTDFYRIDFPTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSP 1039
            ....|:.:..:......|..:.::..::|.||              |:|..||.|      ..||
 Frog   893 GELESRLELLQAQLERLETRMSSDISIILQLL--------------QRQLSQIPP------AYSP 937

  Fly  1040 SDH---NL------ASSKERLITSSAVPTPGRIYPPLDDENSNDFRWTMKHSASHHSCCKSTDAL 1095
            :.|   ||      :.|.|.:.:|.::.....::|                             |
 Frog   938 ASHSSQNLGLYQTTSKSLEPVKSSPSMSAESPVFP-----------------------------L 973

  Fly  1096 LSP-----EEQPPISILPVDATPAPSVQEVRSSKRSLRKSTSGSNSSLSSSSSSSNSCLVSQSTG 1155
            .||     .:..|:||.|                .:|...|....:|.|...:......|.|:.|
 Frog   974 QSPCLTDYNDVEPLSIKP----------------NTLNLHTGSQETSSSPPGNGHPQAHVGQALG 1022

  Fly  1156 N 1156
            |
 Frog  1023 N 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS_9	40..133	CDD:463873	42/92 (46%)
		PLN03192	270..>650	CDD:215625	187/399 (47%)
		cNMP	586..716	CDD:197516	50/129 (39%)
kcnh6	XP_012808358.2	PAS_9	38..132	CDD:463873	41/93 (44%)
		PLN03192	260..>668	CDD:215625	192/410 (47%)