Protein Alignment Elk and kcnh5b

DIOPT Version :9

• Sequence 1: NP_477009.1
• Gene: Elk / 37047
• FlyBaseID: FBgn0011589
• Length: 1284
• Species: Drosophila melanogaster
• Sequence 2: XP_002664253.1
• Gene: kcnh5b / 100331767
• ZFINID: ZDB-GENE-090319-1
• Length: 1005
• Species: Danio rerio
• Alignment Length: 1090
• Identity: 328/1090 - (30%)
• Similarity: 532/1090 - (48%)
• Gaps: 224/1090 - (20%)

  Fly     1 MP-ARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            || .::||:|||||||:.|..|  .:.::|:|||||....|:||.:|||..|:||.||::|||..
Zfish     1 MPGGKRGLVAPQNTFLENIVRR--SSETSFLLGNAQIVDWPVVYSNDGFCKLSGYHRAEVMQKSS 63

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            :|.|:||..|.::...::.::..|......||:.|:|...|.|....|.||:||...|||||.:.
Zfish    64 TCSFMYGELTDKKTIDKVRQAFDNYESNCFEVLLYRKNRTPVWFYMQIAPIRNENDKVVLFLCTF 128

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            ||||   :.:..:.:|....:...|.|.    ||.:|
Zfish   129 KDIT---VFKQPIEDESTRGWTKFARLT----RALTN---------------------------- 158

  Fly   195 NLDVPAGCNMGRRRSRAVLYQLS-------GHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQS 252
                          |::.:.|::       ..:||.:  :...|:||::.:       |:||.::
Zfish   159 --------------SKSTIQQITPVSRTDVTSHKPSR--LAEVLQLGSDIL-------PQYKQEA 200

  Fly   253 IKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAF-AKADRQT-KVSDVIVEALFIVDILL 315
            .|....|:.||..||..||||||:.|||.|:|||||.:| .|.:..| .|.|.:|:.:|:|||:|
Zfish   201 PKTPPHIILHYCTFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNVTWLVLDSVVDVIFLVDIVL 265

  Fly   316 NFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYD-GEDSHIHLVKLTRLL 379
            ||.||||...|||:|:...|.:|||:.||.:|||:.||:|.:.|.:..| |..|....:|:.|||
Zfish   266 NFHTTFVGPGGEVISDPNLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLL 330

  Fly   380 RLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYEWFPE-----SNIGWLQLL 439
            ||.|:.:|:|.|.::.|.:|.||:..|.|.|||||||||  ::.:||...|     ....||..|
Zfish   331 RLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWY--SIGDYEVIDEQTNTIKTDSWLFQL 393

  Fly   440 AE------RKNASVAILTTAE---------TYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIM 489
            |.      |.|||    .|.:         .|.|:||||.||||::||||::..|..||:|::.|
Zfish   394 ATSIGSPYRYNAS----GTGQWEGGPGKDSLYITSLYFTMTSLTTIGFGNIAPTTDGEKIFSVAM 454

  Fly   490 MLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSH 554
            |::|:|::|.:|||||.|.|:||:..:.|.....:::||:.|:.:||.|.:|:.||..::||:|.
Zfish   455 MMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSK 519

  Fly   555 GIDIYETLREFPEELRGDVSMHLHREIL-QLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGD 618
            |||..:.|...|:::|.|:.:||:|::. :.|.|..||.|||:.|::..:....|||:.:.|.|:
Zfish   520 GIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRSLAVEFQMIHSAPGDLIFHAGE 584

  Fly   619 ALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSD 683
            :::.:.::.:||:|||:||.|:|||||||:.|   :|....|:               :..|.::
Zfish   585 SVDLLCFVVSGSLEVIQDDEVIAILGKGDVFG---DVFWKETT---------------LAHSCAN 631

  Fly   684 IKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYENQDSDIGPSFPLPSISE 748
            ::|||||||..|....|::||..|..:...|:.::  .||||||:.:..:        .:..:.:
Zfish   632 VRALTYCDLHIIKREALLKVLDFYTAFANSFSRNL--FLTCNLRKRFVFR--------KIIDVKK 686

  Fly   749 DDENREEAE-----------------EGGKGEKE--NGGG---------------PPSGASPLHN 779
            ::|.|:.::                 :..|.:||  |.|.               |...:.|..:
Zfish   687 EEEERQRSKNEVPLTIPVDHPVRKLFQKFKQQKELRNQGASAQLDLEKNQHHLQQPARMSKPHTS 751

  Fly   780 ISNSPLHATR-------------SPLLG-MGSPR-NQRLHQRGRSLITLR-------------ET 816
            :..:.|||.:             :|:.. :..|: ...:.|..|..:.|:             :.
Zfish   752 LMQNSLHAVQNGSTSSVVTISQITPIQNCLAYPKPGDSIKQNNRDFMELKPAVVTSEQVANRLKV 816

  Fly   817 NKRHRTLNAACS-----LDRGSFEEPEPLEEEQSSG----GKRPSLERLDSQVSTLHQDVAQL-- 870
            |...||..|..:     |.........|.|:|:..|    .|..|:||:.|:|....::|..:
Zfish   817 NNTARTKPAGAARGWMRLKNNRAAPGSPPEDERKEGLNNAAKAVSMERIASEVKVQIENVEDVGG 881

  Fly   871 --SAEVRNAISALQEMTFTSNAMTSHSSLKFP--------PARSIPNISGVAGTRSGVAVEHGLM 925
              .:.:|...|....:|::...:...|..:.|        |:......:.:...|..:.:|...:
Zfish   882 SRKSSLRKTDSLDSGLTYSDQRLDRVSEPQSPVPGTGEVYPSSESSFQASLQEARLELRMEIQAL 946

  Fly   926 GGVLAAAE----------LAAMQRSSS----HPPEVWGRDVQLPTSNTAS 961
            .|.:|..|          |.:.:..||    |.|::..:. .:|.||.::
Zfish   947 NGRMATLEERVGQILRLLLDSSKAKSSEDLTHRPKLKAQS-SIPVSNLST 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	37/95 (39%)
		PAS_3	41..129	CDD:285623	35/87 (40%)
		Ion_trans	285..516	CDD:278921	110/253 (43%)
		Ion_trans_2	<455..510	CDD:285168	29/54 (54%)
		Crp	583..>650	CDD:223736	28/66 (42%)
		CAP_ED	586..715	CDD:237999	43/128 (34%)
kcnh5b	XP_002664253.1	PAS	37..131	CDD:238075	37/93 (40%)
		PAS_3	40..127	CDD:285623	35/86 (41%)
		Ion_trans	233..481	CDD:278921	110/253 (43%)
		Ion_trans_2	<421..475	CDD:285168	29/53 (55%)
		Crp	546..>666	CDD:223736	45/137 (33%)
		CAP_ED	552..662	CDD:237999	43/127 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840