DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Elk and kcnh4a

DIOPT Version :9

Sequence 1:NP_477009.1 Gene:Elk / 37047 FlyBaseID:FBgn0011589 Length:1284 Species:Drosophila melanogaster
Sequence 2:NP_001309362.1 Gene:kcnh4a / 100148126 ZFINID:ZDB-GENE-131125-34 Length:1151 Species:Danio rerio


Alignment Length:1296 Identity:493/1296 - (38%)
Similarity:672/1296 - (51%) Gaps:276/1296 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..|||||||||||||||.|||||||||:||||| :.|.|||||||||.:|||::|.::|:|.|
Zfish     1 MPVMKGLLAPQNTFLDTIAKRFDGTHSNFLLGNAQGSRGYPIVYCSDGFCELTGFARTEVMKKTC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            :|.||:|.:|.|...||:||:|..:.|.:.||.:|:|.|..||||.|||||||||.:|||||.|.
Zfish    66 TCQFLHGQETSERVTQQVEKTLEGQREFQTEVCYYRKNGTTFWCLLDIVPIKNEKGEVVLFLLSF 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGN 194
            |:||.                                                 |.|.:..|...
Zfish   131 KNITD-------------------------------------------------SYGKSHLGSST 146

  Fly   195 NLDVPAGCNMG-------RRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQS 252
            ..|...|..:|       |.|.|.|||.|:..:..     ::|.||.||..  ::...||||..|
Zfish   147 EEDRRHGRKVGRTHLSQARERGRNVLYHLTCQFTN-----RSKRKLPNNVF--SQPTLPEYKVAS 204

  Fly   253 IKKSRLILPHYGVFKGIWDWVILVATFYVALMVPYNAAFAKAD-------------RQTKVSDVI 304
            ::|||.||.||.|.|.:|||:||:||||||:.||||..|:..|             |.|.|||:.
Zfish   205 VQKSRFILLHYSVCKAMWDWLILLATFYVAVTVPYNVCFSTPDDSQLDSPDCDSSSRTTIVSDIA 269

  Fly   305 VEALFIVDILLNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSH 369
            ||.|||:||:||||||:|...|:||.:::.|.::|...||.|||:||||||.||..::  ...|.
Zfish   270 VEMLFILDIILNFRTTYVGPAGQVVYDTRSICLHYCTTWFILDLIAALPFDLLYLFNI--SVTSL 332

  Fly   370 IHLVKLTRLLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKE------YEWF 428
            :||:|..|||||.|||||:|.|||::|::|||||..|.|.||||||:||||..:|      ..| 
Zfish   333 VHLLKTVRLLRLLRLLQKLDGYSQYSAVVLTLLMSVFALLAHWLACVWYVIGRQELASNDPLTW- 396

  Fly   429 PESNIGWLQLLAER-----KNASVAILTTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTII 488
               :|||||.|.:|     .|.:|...:....|..:||||.:||||||||||.|||.|||:|:|.
Zfish   397 ---DIGWLQELGKRLETPYTNGTVGGPSLRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSIC 458

  Fly   489 MMLIGALMHAVVFGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLS 553
            .|||||||||||||||||||||||||||||.::.:|||||:.:|.:|::||||:.:||||:||::
Zfish   459 TMLIGALMHAVVFGNVTAIIQRMYSRRSLYHTRMKDLKDFIRVHRLPQQLKQRMLEYFQTTWSVN 523

  Fly   554 HGIDIYETLREFPEELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGD 618
            :||:..|.|.:||:|||.|::|||:::|||||:|.:||:|||:.|||||||:|||||||||..||
Zfish   524 NGINANELLHDFPDELRADIAMHLNKDILQLPLFSSASRGCLRSLSLHIKTSFCAPGEYLIRHGD 588

  Fly   619 ALNYIYYLCNGSMEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSD 683
            ||:..:::|:||:||:||.||:||||||||||:|:                  .|:|.|:::::|
Zfish   589 ALHAQHFVCSGSLEVLKDGMVLAILGKGDLVGADL------------------PGKDQVIKANAD 635

  Fly   684 IKALTYCDLKCIHMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREG-----------YENQDSDI 737
            :||||||||:.|.:..|.|||.|||||..:|..||.|:||.|||||           .|..|   
Zfish   636 VKALTYCDLQYISVRALQEVLELYPEYGSRFNEDIHHNLTYNLREGQARFSRSTRLAQEKFD--- 697

  Fly   738 GPSFPLPSISEDDENREEAEEGGKGEKENGGGPPSGASPL----------HNI---SNSPLHATR 789
              ...||.|.|.::..:..::.|:....:|...||..|.|          ||:   ..||:.::|
Zfish   698 --ECKLPFIVETEQEDDTGQDLGRRPLLSGFSCPSSQSNLSAMLGEEFRHHNMLRFCRSPVQSSR 760

  Fly   790 --SPLLGMGS---------PRNQRL--HQRGRSLITLRETNKRHRTLNAACSLDRG--------- 832
              ||.:.:..         |:..::  ::..:.||.         |||....||..         
Zfish   761 IQSPQIPLHEEQTTASAPVPKTDKISCNRPAKLLIP---------TLNCVSPLDLSPRVVDGIED 816

  Fly   833 ---------------SFEEPEP--------LEEEQSSGGKRPSLERLDSQVSTLHQDVAQLSAEV 874
                           :.|..:|        ||.|:    .|.||.:|:::::.|:|:|..|:.|:
Zfish   817 NEHAFHFNVEHSESPNTEVKDPFQVGANLLLETEE----VRQSLRQLNTEMNHLNQEVTSLTKEL 877

  Fly   875 RNAISALQEMTFTSNAMTSHSSLKFPP--ARSIPNISGVAGTRSG--VAVEHGLMGGVLAAAELA 935
            ...:..|.     ::....|....|.|  ..:..|.:.||.:.:.  ..:.:.:..|....||.:
Zfish   878 HEMMQFLH-----AHVTQPHFPSSFTPFACHTSSNCTSVATSTTDWPSRLSYSMPSGPCLQAEPS 937

  Fly   936 AMQR---------SSSHPPE---VWGRDVQLPTSNTASSKAPSPVEPKKTMTSRSSQTDFYRIDF 988
            ....         |.|||.|   :.|::..|...|.|..       |..|          |....
Zfish   938 RRDSFTPRHSCICSGSHPQERGSILGQEGDLELLNQAQI-------PHST----------YFPCC 985

  Fly   989 PTFERFVLANPRLVLGLLGIEPAIKNEMDLLQQKQTLQISPLNTIDECVSPSDHNLASSKERLIT 1053
            |..||         :..||:|.               |.||..|.:  .:|:...|.........
Zfish   986 PDQER---------VATLGVEN---------------QASPYQTSN--TTPNSPYLGHRPPHAAL 1024

  Fly  1054 SSAVPTPGRIYPPLDDENSNDFRWTMKH---SASHHSCCKSTDALLSPEEQP-PI--SILPVDAT 1112
            :|:.|:.|.:.........::...|..|   |.||.|......:.:.|...| ||  |:.|. ..
Zfish  1025 TSSFPSSGLVPQVRSAVAPSNALPTSAHNIQSQSHGSLNVQMISEMHPRATPTPIHLSVTPT-GP 1088

  Fly  1113 PAPSVQEVRSSKRSLRKSTSGSNSSLSSSSSSSNSCLVSQSTGNLTTTNASVHCSNSSQSV 1173
            |.|.:     |..|:..|...|:|.|...:....:.||..|..: |..|..|...|:|..|
Zfish  1089 PQPLI-----SVSSIMHSGICSSSLLHFPAGQRQNDLVGSSPVH-TLENIVVSTENNSAPV 1143

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ElkNP_477009.1 PAS 36..132 CDD:238075 54/95 (57%)
PAS_3 41..129 CDD:285623 50/87 (57%)
Ion_trans 285..516 CDD:278921 138/254 (54%)
Ion_trans_2 <455..510 CDD:285168 42/54 (78%)
Crp 583..>650 CDD:223736 46/66 (70%)
CAP_ED 586..715 CDD:237999 68/128 (53%)
kcnh4aNP_001309362.1 PAS 42..133 CDD:238075 52/90 (58%)
PAS_3 42..127 CDD:285623 48/84 (57%)
Ion_trans 267..486 CDD:278921 128/224 (57%)
Ion_trans_2 <426..480 CDD:285168 42/53 (79%)
Crp 553..745 CDD:223736 94/214 (44%)
CAP_ED 556..666 CDD:237999 68/127 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170578358
Domainoid 1 1.000 282 1.000 Domainoid score I1613
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 799 1.000 Inparanoid score I482
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D247304at2759
OrthoFinder 1 1.000 - - FOG0000148
OrthoInspector 1 1.000 - - otm25569
orthoMCL 1 0.900 - - OOG6_104228
Panther 1 1.100 - - O PTHR10217
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X71
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.900

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