DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and kcnh3

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_001919436.3	Gene:	kcnh3 / 100006614	ZFINID:	ZDB-GENE-070912-23	Length:	1192	Species:	Danio rerio

Alignment Length:	1296	Identity:	520/1296 - (40%)
Similarity:	702/1296 - (54%)	Gaps:	276/1296 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPARKGLLAPQNTFLDTIATRFDGTHSNFVLGNAQANG-NPIVYCSDGFVDLTGYSRAQIMQKGC 64
            ||..:||||||||||||||||||||||||||||||... .|||||||||.:||||:||::|||.|
Zfish     1 MPVMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVQSLYPIVYCSDGFCELTGYARAELMQKSC 65

  Fly    65 SCHFLYGPDTKEEHKQQIEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASH 129
            :|||||||:|.:....||:.:|..:.|.|.|::||||.|..||||.|||||||||.:|||||.||
Zfish    66 ACHFLYGPETSDRLMAQIQGALDERREFKTELVFYKKGGTQFWCLLDIVPIKNEKGEVVLFLVSH 130

  Fly   130 KDITHTKMLEMNVNEECDSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAG-EG 193
            ||||..|   .:.:||                                    .:.:.|.|.| |.
Zfish   131 KDITDNK---KDQDEE------------------------------------QSPERDEETGLEV 156

  Fly   194 NNLDVPAGCNMGRRRSRAVLYQLSGHYKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRL 258
            :.:..|.|.|..||||||||||||||.:.:.   |:|||:.|| |...:.|.||||..:|:|||.
Zfish   157 HKVTRPPGFNANRRRSRAVLYQLSGHLQKQD---KSKLKINNN-MFGEKPPIPEYKVAAIQKSRF 217

  Fly   259 ILPHYGVFKGIWDWVILVATFYVALMVPYNAAF--------AKADRQ-TKVSDVIVEALFIVDIL 314
            ||.|||.||..|||:||:||||||:.||||..|        |...|. ..|||::||.||::||:
Zfish   218 ILLHYGTFKAGWDWLILLATFYVAVTVPYNVCFTVVGGRDEASTPRSPPSVSDILVEILFMLDIV 282

  Fly   315 LNFRTTFVSRKGEVVSNSKQIAINYLRGWFALDLLAALPFDHLYASD--LYDGEDSHIHLVKLTR 377
            |||||||||..|:||.:::.|.::|:..|..:||:||||||.|||.:  :|.|    :||:|..|
Zfish   283 LNFRTTFVSTSGQVVYDARSICVHYVTTWLFVDLIAALPFDLLYAFNVSVYFG----VHLLKTVR 343

  Fly   378 LLRLARLLQKIDRYSQHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE------WFPESNIGWL 436
            ||||.|||||::||||::|::|||||..|.|.|||:||:||:|...|.|      |    :||||
Zfish   344 LLRLLRLLQKLERYSQYSAVVLTLLMSMFALLAHWMACVWYIIGRSEIENNSPGSW----DIGWL 404

  Fly   437 QLLAER----------------------------------------------------------- 442
            ..|.:|
Zfish   405 HELGKRLGTPYFLSPLASLIPDSLRPTILDGLVVNSSQWNGSDLVAHEPVWNSSQLNSTGTAPAA 469

  Fly   443 -KNA--SVAIL----TTAETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVV 500
             .||  :.|:|    :...:|.|:|||..:||||||||||||||.:||:|:|..|||||||||.|
Zfish   470 PSNAGQTGAVLGGGPSIRSSYVTSLYFALSSLTSVGFGNVSANTDSEKIFSICTMLIGALMHAAV 534

  Fly   501 FGNVTAIIQRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREF 565
            ||||||||||||||||||.::.:|||||:.:|.:||.|.||:.:.|||:||:::|||:.|.|::|
Zfish   535 FGNVTAIIQRMYSRRSLYHTRTKDLKDFIRVHRLPKALAQRMLECFQTTWSVNNGIDVSELLKDF 599

  Fly   566 PEELRGDVSMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGS 630
            |:|||.|::|||::|:||||:||:||:|||:.|||.|||:||||||:||.:||||..||::|:||
Zfish   600 PDELRADIAMHLNKELLQLPLFESASRGCLRSLSLIIKTSFCAPGEFLIRQGDALQAIYFVCSGS 664

  Fly   631 MEVIKDDMVVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCI 695
            |||:||:.|:||||||||:|||                  |..::.|:::::::||||||||:.|
Zfish   665 MEVLKDNTVLAILGKGDLIGSD------------------SLTKEQVIKTNANVKALTYCDLQYI 711

  Fly   696 HMGGLVEVLRLYPEYQQQFANDIQHDLTCNLREGYE---NQDSDIGPSFPLPSISEDDENREEAE 757
            .:.||.|||||||||.|:|.::||||||.|||||..   :.:|:.|....||:|.||:||.||..
Zfish   712 SLKGLREVLRLYPEYAQKFVSEIQHDLTYNLREGSGADLDWESNGGLVKKLPAIREDEENDEEQN 776

  Fly   758 EGGKGEKENGGGPPSGASPLH--NISNSPLHATRSPLLGMGSPRNQRLHQRGRSLITLR------ 814
            ...:..:          |||.  ...:|||   |||||   .||..|.........||:
Zfish   777 SVSRAPR----------SPLRLTRALSSPL---RSPLL---PPRPFRAPSESMRPATLQIPVVSF 825

  Fly   815 -----ETNKRH----RTLNAACSLDRGSF---------EEPEPLEEEQSSGGKRPSLERLDSQVS 861
                 |.:.|.    .|.:.:.|..|..|         ..|.|:.:||..  .:.|:.:|..:::
Zfish   826 SSAPPELSPRFVDGIETESNSSSTQRFEFGPSLPQSGPPSPSPVSQEQLE--SKQSITKLSEEMT 888

  Fly   862 TLHQDVAQLSAEV---------------RNAISALQEMTFTSNAMTSHSSLKFPPARSIPNISGV 911
            :|.|.|:|||.|:               :..::||......|.:..|..::..|||.| |..|..
Zfish   889 SLSQQVSQLSKELQEMTRLLRPILVMGSQTLLTALSPTMPQSPSSCSGPTIPTPPAPS-PTASPS 952

  Fly   912 AGTRSGVAVEHGLMGGVLAAAELAAMQRSS----SHPPEVWGRDVQLPTSNTASSKAP------S 966
            ...|...:        :|.:|:..::...|    :.||  .....|:..|.|..|:.|      |
Zfish   953 TPLRPTCS--------LLDSADTGSIGLPSCLLPTSPP--LRPHAQVQVSPTGCSRGPSLPVLIS 1007

  Fly   967 PV---------------EPKKTMTSRSSQTDFYRIDFPTF-ERFVLANPRLVLGLLGIEPAIKNE 1015
            ||               .|:.......|.|..|.:  |:| .:....:|     ..|......:.
Zfish  1008 PVTAQTEGPGTQAAPNQPPQANQPPSPSLTFSYSL--PSFRSQSSSCSP-----CQGPHRPASHS 1065

  Fly  1016 MDLLQQKQTLQISPLNTIDECVSPSDHNLASSKERLITSS--AVPTPGRIYPPLDDENSNDFRWT 1078
            ..||.|..:|. :|...:..|.:|...|.:...:|:..|.  :.|:..||.|......|:    :
Zfish  1066 RGLLPQPPSLD-NPNPPLSHCSAPPSINNSPGDQRVGFSQFPSSPSSSRIQPRACTPPSS----S 1125

  Fly  1079 MKHSASHHSCCKSTDALLSPEEQPPI--SILPVDATPAPSVQEVRSSKRSLRKSTSGSNSS 1137
            ..|::....|  |.|:|  ||.|...  |.||.:..|.|...|:...:.:   :|:|..|:
Zfish  1126 CPHTSPPLPC--SLDSL--PETQASFGPSWLPQNTVPGPPQLEIEMQEWA---ATAGRPST 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	59/96 (61%)
		PAS_3	41..129	CDD:285623	55/87 (63%)
		Ion_trans	285..516	CDD:278921	137/313 (44%)
		Ion_trans_2	<455..510	CDD:285168	41/54 (76%)
		Crp	583..>650	CDD:223736	47/66 (71%)
		CAP_ED	586..715	CDD:237999	70/128 (55%)
kcnh3	XP_001919436.3	PAS	42..133	CDD:238075	58/90 (64%)
		PAS_3	42..130	CDD:285623	55/87 (63%)
		PLN03192	180..>684	CDD:215625	257/515 (50%)
		Ion_trans_2	<489..544	CDD:285168	41/54 (76%)
		CAP_ED	620..731	CDD:237999	70/128 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1613
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	799	1.000	Inparanoid score	I482
OMA	1	1.010	-	-		QHG48155
OrthoDB	1	1.010	-	-		D180867at33208
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm25569
orthoMCL	1	0.900	-	-		OOG6_104228
Panther	1	1.100	-	-	LDO	PTHR10217
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980