DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elk and kcnh8

DIOPT Version :9

Sequence 1:	NP_477009.1	Gene:	Elk / 37047	FlyBaseID:	FBgn0011589	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_017207899.2	Gene:	kcnh8 / 100002967	ZFINID:	ZDB-GENE-060503-204	Length:	975	Species:	Danio rerio

Alignment Length:	1028	Identity:	425/1028 - (41%)
Similarity:	583/1028 - (56%)	Gaps:	196/1028 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GTH------SNFVLGNAQ-ANGNPIVYCSDGFVDLTGYSRAQIMQKGCSCHFLYGPDTKEEHKQQ 81
            |:|      |||:|.||| :.|.|||||||||.:|||::|.::||:.|:|.|||||:|.|.....
Zfish    14 GSHSLVLADSNFILANAQVSKGFPIVYCSDGFCELTGFARTEVMQQSCACKFLYGPETSEHIILH 78

  Fly    82 IEKSLSNKMELKLEVIFYKKEGAPFWCLFDIVPIKNEKRDVVLFLASHKDITHTK---MLEMNVN 143
            ::.:|..:.|||.|::||||.|:.||||.|||||||||.||||||||.||:|.||   .|| ...
Zfish    79 VDAALEERSELKEEIMFYKKSGSVFWCLLDIVPIKNEKGDVVLFLASFKDVTDTKAKSTLE-EKK 142

  Fly   144 EEC-------DSVFALTAALLGARFRAGSNAGMLGLGGLPGLGGPAASDGDTEAGEGNNLDVPAG 201
            |||       ||.|..|
Zfish   143 EECRREKVKGDSPFGST------------------------------------------------ 159

  Fly   202 CNMGRRRSRAVLYQLSGH-YKPEKGGVKTKLKLGNNFMHSTEAPFPEYKTQSIKKSRLILPHYGV 265
                |.||..|||.:||| :..:|   ::|:||..|......| .||||....|||:.||.|:..
Zfish   160 ----RLRSSTVLYHISGHLHNRQK---QSKIKLNKNVFGDPPA-LPEYKVADAKKSKFILLHFST 216

  Fly   266 FKGIWDWVILVATFYVALMVPYNAAF---AKADRQTKVSDVIVEALFIVDILLNFRTTFVSRKGE 327
            ||..|||:||:||||||:.||||..|   ....|.|.|:|:.||.|||:||:.:||||:||:.|:
Zfish   217 FKAGWDWLILLATFYVAVTVPYNVCFIGDQDLTRSTTVTDIAVEILFIIDIVFSFRTTYVSKSGQ 281

  Fly   328 VVSNSKQIAINYLRGWFALDLLAALPFDHLYASDLYDGEDSHIHLVKLTRLLRLARLLQKIDRYS 392
            |:.:::||.|:|:..||.:||:||||||.|||..:  ...|.:||:|..|||||.|||||:||||
Zfish   282 VIFDARQICIHYMTTWFIIDLVAALPFDLLYAFKV--SVVSVVHLLKTVRLLRLLRLLQKMDRYS 344

  Fly   393 QHTAMILTLLMFSFTLAAHWLACIWYVIAVKEYE-----WFPESNIGWLQLLAERKNA---SVAI 449
            ||:.::|||||..|.|.|||:|||||:|..||.|     |    :||||..|.:|..:   .||.
Zfish   345 QHSTVVLTLLMSMFALLAHWMACIWYIIGKKEVESNADTW----DIGWLHELGKRLESPYEGVAN 405

  Fly   450 LTTA------ETYSTALYFTFTSLTSVGFGNVSANTTAEKVFTIIMMLIGALMHAVVFGNVTAII 508
            .|.:      ..|..|||||.:||||||||||||||.|||:|:|..|||||||||:|||||||||
Zfish   406 RTLSSGPSLRSIYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAII 470

  Fly   509 QRMYSRRSLYESKWRDLKDFVALHNMPKELKQRIEDYFQTSWSLSHGIDIYETLREFPEELRGDV 573
            ||||||.|.|.::.:|||||:.:|::|:.||||:.:||||:||:::|||..|.||:||:|||.|:
Zfish   471 QRMYSRWSSYHTRTKDLKDFIRVHHLPQSLKQRMLEYFQTTWSVNNGIDSNELLRDFPDELRSDI 535

  Fly   574 SMHLHREILQLPIFEAASQGCLKLLSLHIKTNFCAPGEYLIHKGDALNYIYYLCNGSMEVIKDDM 638
            :|||::|||:|.:|.:.|:|||:.|||||||:||||||||:.:||||..::::|:|||||:||:|
Zfish   536 AMHLNKEILELSVFSSLSRGCLRSLSLHIKTSFCAPGEYLLRQGDALQALFFVCSGSMEVLKDNM 600

  Fly   639 VVAILGKGDLVGSDINVHLVATSNGQMTATTNSAGQDVVVRSSSDIKALTYCDLKCIHMGGLVEV 703
            |:||||||||:|::::|                  .|.|:::::|:||||||||:||::.||.||
Zfish   601 VLAILGKGDLIGANMSV------------------GDRVIKTNADVKALTYCDLQCINLRGLYEV 647

  Fly   704 LRLYPEYQQQFANDIQHDLTCNLREGYENQ------------------DSDIGPSFP--LPSISE 748
            |.|||||..:|..||.||||.|||||.|:.                  :.|....:|  ....:|
Zfish   648 LDLYPEYSHRFVQDITHDLTYNLREGQESHVISRMSSKSMDTQMEGRGNGDAIQCYPPIAEHHNE 712

  Fly   749 DDENREEAEEGGKGEKENGGGPPSGASPLHNISNSPLH----ATRSPLLGMGSPR---------- 799
            :|::.::.|:........||...:......:.:|..||    ....|.||..|||
Zfish   713 EDDDDDDDEDDQIQYLSGGGKQKTHMQKNDHQTNKKLHIQHTTVTKPDLGNLSPRVVDGTEDSDG 777

  Fly   800 NQRLHQRGRSLITLRETNKRHRTLNAACSLDRGSFEEPEPLEEEQSSGGKRPSLERLDSQVSTLH 864
            .:..|       |...::....:::.|.:....:.|.....|:      .|..|..|:.:||:|.
Zfish   778 TENSH-------TFIFSSAHQHSVSGATNTTATTAELAAKSED------TRGQLRHLNQEVSSLG 829

  Fly   865 QDVAQLSAEVRNAISALQEM--------TFTSNAMTSHSSLKFPP--------ARSIPNISGVAG 913
            ::||:|...:|:....::.|        .:||...:.|.|   ||        :.|.||...
Zfish   830 REVAELGRVMRSLAFLIESMMASPQTPGVYTSTFTSGHPS---PPVPFQGQGSSWSSPNFPS--- 888

  Fly   914 TRSGVAVEHGLMGGVLAAAELAAMQRSSSHPPEVWGRDVQLPTSNTASSKAPS 966
                 .:..|:..|.|.:..|...:...|.|      |......:|:|:.:|:
Zfish   889 -----PMHPGIHPGGLISLPLRPQELQCSRP------DPLAKPGDTSSTTSPT 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elk	NP_477009.1	PAS	36..132	CDD:238075	57/95 (60%)
		PAS_3	41..129	CDD:285623	53/87 (61%)
		Ion_trans	285..516	CDD:278921	139/247 (56%)
		Ion_trans_2	<455..510	CDD:285168	43/54 (80%)
		Crp	583..>650	CDD:223736	43/66 (65%)
		CAP_ED	586..715	CDD:237999	67/128 (52%)
kcnh8	XP_017207899.2	PAS_9	36..131	CDD:315989	57/94 (61%)
kcnh8	XP_017207899.2	Ank_2	193..>620	CDD:330894	245/451 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578364
Domainoid	1	1.000	282	1.000	Domainoid score	I1613
eggNOG	1	0.900	-	-		E1_KOG0498
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	799	1.000	Inparanoid score	I482
OMA	1	1.010	-	-		QHG48155
OrthoDB	1	1.010	-	-		D247304at2759
OrthoFinder	1	1.000	-	-		FOG0000148
OrthoInspector	1	1.000	-	-		otm25569
orthoMCL	1	0.900	-	-		OOG6_104228
Panther	1	1.100	-	-	O	PTHR10217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4902
SonicParanoid	1	1.000	-	-		X71
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800