DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PPO1 and PPO3

DIOPT Version :9

Sequence 1:	NP_476812.1	Gene:	PPO1 / 37044	FlyBaseID:	FBgn0283437	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_524760.1	Gene:	PPO3 / 44513	FlyBaseID:	FBgn0261363	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	331/688 - (48%)
Similarity:	454/688 - (65%)	Gaps:	25/688 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DLKALELMFQRPLEPAFTTRDSGKTVLELPDSFYTDRYRNDTEEVGNRFSKDVDLKIPIQELSNV 69
            |.|.|.|:|..|.||.|..:....||.::|||:.||||....::|..|.|...:..:.::|:: :
  Fly     3 DKKNLLLLFDHPTEPVFMDKGGNGTVFDVPDSYVTDRYNQMCKKVQRRVSSASEKNVQVKEIA-I 66

  Fly    70 PSLEFTKKIGLKNQFSLFNNRHREIASELITLFMSAPNLRQFVSLSVYTKDRVNPVLFQYAYAVA 134
            |.|..:.::|...|||:|...||::||.||.:|.....:.:..|::||.:||||||||.||.:||
  Fly    67 PDLSCSMRLGRSEQFSIFLKSHRKMASHLIEIFTKMQTVDELQSVAVYARDRVNPVLFNYALSVA 131

  Fly   135 VAHRPDTREVPITNISQIFPSNFVEPSAFRDARQEASVIGESGARVHVDIPQNYTASDREDEQRL 199
            :.|||||:::.:...:|.||..|::....|..|:|:.|:..|.||:.|.....|||||.:.|.||
  Fly   132 LLHRPDTKDLELPAFAQTFPDRFIDSKMLRSMREESFVVERSAARLPVVSSVKYTASDLDVEHRL 196

  Fly   200 AYFREDIGVNSHHWHWHLVYPTTGP-TEVVNKDRRGELFYYMHHQILARYNVERFCNNLKKVQPL 263
            .|||||:|||.||||||||||...| ..:|:||||||||||||.||:||||.||..|::.:|||.
  Fly   197 WYFREDLGVNLHHWHWHLVYPIEAPDRSIVDKDRRGELFYYMHQQIIARYNAERLSNHMARVQPF 261

  Fly   264 NNLRVEVPEGYFPKILSSTNNRTYPARVTNQKLRDVDRHDG--RVEISDVERWRDRVLAAIDQGY 326
            |||...:.||||||:.|...:|.||.|..|.:|.||||.:.  ||.|.|::|||:|:..||.|||
  Fly   262 NNLDEPIAEGYFPKMDSLVASRAYPPRFDNTRLSDVDRPNNQLRVGIDDMKRWRERIYEAIHQGY 326

  Fly   327 VEDSSGNRIPLDEVRGIDILGNMIEASPVLSINYNFYGNLHNEGHNIISFAHDPDYRHLEEFGVM 391
            |.|::..:|.||:.:|||||||:||||. |:.|...||:.||.||.:|:::|||..:|||..|||
  Fly   327 VLDTNNEKIVLDDAKGIDILGNIIEASD-LTPNSTLYGDFHNMGHILIAYSHDPTNKHLEYAGVM 390

  Fly   392 GDVTTAMRDPIFYRWHGFIDTVFNKFKTRLNPYNAGELNFDGITVDYIEAKIGKSNTKANTLLTY 456
            ||.:|||||||||:||.|||.:|.:.|..|:||...||:|..:.|:.|:.   :|..:.|.|.|:
  Fly   391 GDASTAMRDPIFYKWHAFIDNMFQEHKRLLSPYEKQELSFPDVRVESIQV---ESQGQVNRLTTF 452

  Fly   457 WQKSSADLAAGLDFGPTTDRNIFASFTHLQNAPFTYTFNVTNNG-ARRTGTCRIFICPKVDERNQ 520
            ||:|..|::.||||.|.  .::.|.|||||:..|:||..|.|:. |.|.|..|||:.||:|:||.
  Fly   453 WQESDVDMSRGLDFVPR--GHVLARFTHLQHHEFSYTIKVENSSEATRYGYVRIFLAPKLDDRNA 515

  Fly   521 ALNLEEQRLLAIEMDKFTVDLVPGENTIRRQSTESSVAIPFERSFRPVGADYQPKAADELARFKF 585
            .:.||:|||:.:|:|||.|.:.||.:||.|.||||||.|||||:||.:      ...:||..| .
  Fly   516 PMLLEQQRLMMVELDKFVVTMPPGSHTITRNSTESSVTIPFERTFRNL------DKLEELQNF-L 573

  Fly   586 CGCGWPQHLLLPKGNAQGMVFDLFVMISDYSQDSVEQPKTPND-ACSTAYSFCGLKDKLYPDRRT 649
            ||||||||:|:|||..:|:.|:||||:|:|.:|.|:|  |..| .||.|.|:|||:|:|||||::
  Fly   574 CGCGWPQHMLIPKGRPEGLRFELFVMVSNYEEDKVDQ--TVADCGCSIAASYCGLRDRLYPDRKS 636

  Fly   650 MGYPFDRRLPNANLTELVGAF--GNMAKTDLRIVFNDR 685
            ||:||||: |... :|::..|  .||...::.|...||
  Fly   637 MGFPFDRK-PRRG-SEILENFLTPNMCAVEVIITHEDR 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPO1	NP_476812.1	Hemocyanin_N	27..142	CDD:281684	46/114 (40%)
		Hemocyanin_M	152..414	CDD:278784	146/264 (55%)
		Hemocyanin_C	423..682	CDD:281685	123/262 (47%)
PPO3	NP_524760.1	Hemocyanin_N	19..140	CDD:281684	48/121 (40%)
		Hemocyanin_M	150..413	CDD:278784	146/263 (56%)
		Hemocyanin_C	422..669	CDD:281685	123/262 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C4CE
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D136379at33208
OrthoFinder	1	1.000	-	-		FOG0012704
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11511
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850