DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mapmodulin and ANP32A

DIOPT Version :9

Sequence 1:	NP_001097361.1	Gene:	Mapmodulin / 37043	FlyBaseID:	FBgn0034282	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_006296.1	Gene:	ANP32A / 8125	HGNCID:	13233	Length:	249	Species:	Homo sapiens

Alignment Length:	365	Identity:	126/365 - (34%)
Similarity:	163/365 - (44%)	Gaps:	130/365 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEKRIELERRARKVNQITELNLDNCRST--SIVGLTDEYTALESLSLINVGLTTLKGFPKLPNLK 63
            |.:||.||.|.|..:.:.||.|||.||.  .:.|||||:..||.||.||||||::...|||..||
Human     3 MGRRIHLELRNRTPSDVKELVLDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLK 67

  Fly    64 KLELSDNRISSGLNYLTTS-PKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDLFNNDATQVDNYR 127
            ||||||||:|.||..|... |.|.:|||||||||||.|::||::.:||..|||||.:.|.:::||
Human    68 KLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNDYR 132

  Fly   128 EKIFKMLPSLNFLDGFDCNDEEVQSDGDDDDEVNGNDSDEVGDKCNAFCLNGLEIDLDELEAFEK 192
            |.:||:||.|.:|||:|.:|:|. .|.|.:..|.|.|.:|
Human   133 ENVFKLLPQLTYLDGYDRDDKEA-PDSDAEGYVEGLDDEE------------------------- 171

  Fly   193 RVKAKKSLQDKPPPQSEDKEVDELDEYLKELQLRESTDASTDEQSVINATPQPPSNSNLSFVILL 257
                            ||::.:|.||               |.|.|
Human   172 ----------------EDEDEEEYDE---------------DAQVV------------------- 186

  Fly   258 YWFLAILNLGSATYFSDEDDDSDDSDEEANGEVSLSEVYNDDLEEDNSDWEGEDEAGEEDEEEDS 322
                               :|.:|.|||..||           |||.|..|.|||.|..|.|.|
Human   187 -------------------EDEEDEDEEEEGE-----------EEDVSGEEEEDEEGYNDGEVD- 220

  Fly   323 DIDDADGDANESAASVNAKDKDGEKEADESQVRGKKRKHD 362
                               |::.|:|..|.: ||:|||.:
Human   221 -------------------DEEDEEELGEEE-RGQKRKRE 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mapmodulin	NP_001097361.1	leucine-rich repeat	17..39	CDD:275380	12/23 (52%)
		LRR_4	38..74	CDD:289563	23/35 (66%)
		LRR_8	40..95	CDD:290566	35/55 (64%)
		leucine-rich repeat	40..61	CDD:275380	13/20 (65%)
		LRR_4	60..103	CDD:289563	28/43 (65%)
		leucine-rich repeat	62..84	CDD:275380	14/22 (64%)
		LRR_4	83..125	CDD:289563	24/41 (59%)
		leucine-rich repeat	85..109	CDD:275380	15/23 (65%)
		leucine-rich repeat	110..136	CDD:275380	13/25 (52%)
ANP32A	NP_006296.1	LRR 1. /evidence=ECO:0000269\|PubMed:17567741	18..38		8/19 (42%)
		LRR 2. /evidence=ECO:0000269\|PubMed:17567741	43..64		12/20 (60%)
		LRR 3. /evidence=ECO:0000269\|PubMed:17567741	65..87		14/21 (67%)
		LRR_9	<71..146	CDD:405295	41/74 (55%)
		LRR 4. /evidence=ECO:0000269\|PubMed:17567741	89..110		14/20 (70%)
		leucine-rich repeat	90..114	CDD:275380	15/23 (65%)
		leucine-rich repeat	115..141	CDD:275380	13/25 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..249		46/221 (21%)
		Necessary for tumor-suppressive function	150..174		9/65 (14%)
		Interaction with E4F1. /evidence=ECO:0000250	165..249		39/202 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2739
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3779
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59800
OrthoDB	1	1.010	-	-		D1622194at2759
OrthoFinder	1	1.000	-	-		FOG0001011
OrthoInspector	1	1.000	-	-		otm40376
orthoMCL	1	0.900	-	-		OOG6_102163
Panther	1	1.100	-	-	LDO	PTHR11375
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2396
SonicParanoid	1	1.000	-	-		X672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800