DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14490 and Jph2

DIOPT Version :9

Sequence 1:	NP_611274.1	Gene:	CG14490 / 37041	FlyBaseID:	FBgn0034281	Length:	197	Species:	Drosophila melanogaster
Sequence 2:	NP_001192005.1	Gene:	Jph2 / 59091	MGIID:	1891496	Length:	696	Species:	Mus musculus

Alignment Length:	204	Identity:	57/204 - (27%)
Similarity:	74/204 - (36%)	Gaps:	57/204 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SGVRSQRYPGGQYQGKWLGQQPHGF-----------------------GVKQTSSGLVYEGHWQK 51
            ||.|.....||.|.|.|.|.:.||.                       ||....||..:||:|.:
Mouse     2 SGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQ 66

  Fly    52 GQRHGIGSLRRKELDGRMERIYVGQWRENKRSGEG-KQFYPDGSVYFGQWLADQRSGEGILWQAD 115
            |:|||:|.    |..||.  :|.|:|....:...| :|....|:.|.|.|....:.|.|....||
Mouse    67 GKRHGLGI----ETKGRW--LYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYAD 125

  Fly   116 GGIYVGEWLRDKMHEKGLLFTATGNRYVGQFEGGCKSGSGVFYHASNGQRIQHGFWSKDICRTSL 180
            ||                       .|.|||..|.:.|.||......|..:.    .:...||||
Mouse   126 GG-----------------------TYQGQFTNGMRHGYGVRQSVPYGMAVV----VRSPLRTSL 163

  Fly   181 LSLPQDKNN 189
            .||..:.:|
Mouse   164 SSLRSEHSN 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14490	NP_611274.1	COG4642	35..170	CDD:226989	39/135 (29%)
Jph2	NP_001192005.1	Bipartite nuclear localization signal. /evidence=ECO:0000269\|PubMed:30409805	345..359
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..664
		PHA03307	442..>643	CDD:223039
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:30409805	488..492
		PLN03185	4..>143	CDD:215619	45/167 (27%)
		MORN 1. /evidence=ECO:0000255	14..36		6/21 (29%)
		MORN 2. /evidence=ECO:0000255	38..59		4/20 (20%)
		MORN 3. /evidence=ECO:0000255	60..79		9/22 (41%)
		MORN 4. /evidence=ECO:0000255	82..104		5/21 (24%)
		PLN03185	103..>328	CDD:215619	26/97 (27%)
		MORN 5. /evidence=ECO:0000255	106..128		9/44 (20%)
		MORN 6. /evidence=ECO:0000255	129..151		8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..192		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..273
		MORN 7. /evidence=ECO:0000255	285..307
		MORN 8. /evidence=ECO:0000255	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900