DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14490 and ALS2CL

DIOPT Version :9

Sequence 1:	NP_611274.1	Gene:	CG14490 / 37041	FlyBaseID:	FBgn0034281	Length:	197	Species:	Drosophila melanogaster
Sequence 2:	NP_001177636.1	Gene:	ALS2CL / 259173	HGNCID:	20605	Length:	953	Species:	Homo sapiens

Alignment Length:	177	Identity:	52/177 - (29%)
Similarity:	79/177 - (44%)	Gaps:	12/177 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YQGKWLGQQPHGFGVKQTSSGLVYEGHWQKGQRHGIGSLRRKELDGRMERIYVGQWRENKRSGEG 86
            |:..|......|:|:.:.|:..||:|::|:|.|||.|.|.......:..| |.|.|...:|||.|
Human   409 YKCHWREGSMCGYGICEYSTDEVYKGYFQEGLRHGFGVLESGPQAPQPFR-YTGHWERGQRSGYG 472

  Fly    87 KQFYPD-GSVYFGQWLADQRSGEGILWQADGGIYVGEWLRDKMHEKGLLFTATGNRYVGQF---- 146
            .:...| |..|.|.|.|.||.|.|::....|..|.|.:..||....|:|.:...:.|.|.|
Human   473 IEEDGDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRDL 537

  Fly   147 ----EGGCKSGSGVFYHASNGQRIQHGFWSKDICRTSLLSLPQDKNN 189
                :|.....:|.....|.|.....|..::.:..|:  :||.|.::
Human   538 TLMGKGKVTFPNGFTLEGSFGSGAGRGLHTQGVLDTA--ALPPDPSS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14490	NP_611274.1	COG4642	35..170	CDD:226989	44/143 (31%)
ALS2CL	NP_001177636.1	PH-like	223..321	CDD:302622
		COG4642	358..519	CDD:226989	38/110 (35%)
		MORN 1	358..380
		MORN	358..378	CDD:280628
		MORN 2	381..403
		MORN 3	409..431		5/21 (24%)
		MORN 4	432..452		9/19 (47%)
		MORN 5	459..479		7/19 (37%)
		COG4642	480..>569	CDD:226989	24/88 (27%)
		MORN 6	483..505		9/21 (43%)
		MORN 7	506..528		6/21 (29%)
		MORN 8	529..552		5/22 (23%)
		VPS9	834..938	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830