DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment olf186-F and ORAI1

DIOPT Version :9

Sequence 1:	NP_001137696.1	Gene:	olf186-F / 37040	FlyBaseID:	FBgn0041585	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_116179.2	Gene:	ORAI1 / 84876	HGNCID:	25896	Length:	301	Species:	Homo sapiens

Alignment Length:	274	Identity:	138/274 - (50%)
Similarity:	170/274 - (62%)	Gaps:	56/274 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 PPFAAQPPPFQLRTYQQ--NQSYRFQPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKA 316
            ||.|..|||..: ||..  .|||           |..||.:.   ||...||||||.||||||||
Human    39 PPGAPPPPPSAV-TYPDWIGQSY-----------SEVMSLNE---HSMQALSWRKLYLSRAKLKA 88

  Fly   317 SSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCN 381
            ||:|||||||||||||||||||.|.:.|||:||||:.|||:|||||:.|||||||||||||.|.|
Human    89 SSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSN 153

  Fly   382 LHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDL-----------SPPAA 435
            :|:::.|.||||||:|.:||.||||||::|.:|||.|:.:||||||..|           .|||:
Human   154 VHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPAS 218

  Fly   436 WSAC------------------VVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQM 482
            .:|.                  .:::|..:||:.||:||||||||||.:      |:.:.|.|..
Human   219 GAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTD------RQFQELNELA 277

  Fly   483 E----QDHLEHHNN 492
            |    ||.|:|..:
Human   278 EFARLQDQLDHRGD 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf186-F	NP_001137696.1	Orai-1	301..466	CDD:285140	114/193 (59%)
ORAI1	NP_116179.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		6/12 (50%)
		Interaction with STIM1	70..90		15/19 (79%)
		Orai-1	73..267	CDD:285140	114/193 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..225		4/19 (21%)
		Interaction with STIM1	272..292		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2403
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3302
Isobase	1	0.950	-	0	Normalized mean entropy	S4680
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002138
OrthoInspector	1	1.000	-	-		otm41020
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3030
SonicParanoid	1	1.000	-	-		X1421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.940