Protein Alignment Orai and ORAI2

DIOPT Version :10

• Sequence 1: NP_001137696.1
• Gene: Orai / 37040
• FlyBaseID: FBgn0041585
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_116220.1
• Gene: ORAI2 / 80228
• HGNCID: 21667
• Length: 254
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 128/265 - (48%)
• Similarity: 162/265 - (61%)
• Gaps: 37/265 - (13%)

  Fly   235 AASAVAPIAPLAPLASIASPPFAAQPPPFQLRTYQQNQSYRFQPRGHHRTASSSMSQSGEDLHSP 299
            :|....||.|.||          |.|.|     ..:...||...|..:....:|      :.||.
Human     2 SAELNVPIDPSAP----------ACPEP-----GHKGMDYRDWVRRSYLELVTS------NHHSV 45

  Fly   300 TYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHML 364
            ..||||||.||||||||||:||||||||||||||||||:.....|..:||||:.|||:|||||:.
Human    46 QALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLF 110

  Fly   365 ALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYD 429
            ||:||||||||:|.|.|:|:::.:.||||||:|.|||.||.|||:||::|||.|:.:|||:||..
Human   111 ALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLP 175

  Fly   430 LS-------PP-----AAWSAC----VVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEML 478
            :.       ||     ..|.|.    ::::||.:||:.|.||||||||.||.|.....|.||..|
Human   176 VDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKL 240

  Fly   479 KEQME 483
            |.|::
Human   241 KVQLD 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orai	NP_001137696.1	Orai-1	301..466	CDD:462291	106/180 (59%)
ORAI2	NP_116220.1	Orai-1	47..228	CDD:462291	106/180 (59%)