DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment olf186-F and Orai3

DIOPT Version :9

Sequence 1:	NP_001137696.1	Gene:	olf186-F / 37040	FlyBaseID:	FBgn0041585	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001014046.1	Gene:	Orai3 / 309000	RGDID:	1306538	Length:	290	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	123/299 - (41%)
Similarity:	166/299 - (55%)	Gaps:	80/299 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 APLAPLASIASPPFAAQPPPFQLRTYQQNQSYRFQPRGHHRTASSSMSQSGEDLHSPTYLSWRKL 307
            |||.|  .:.||..:|        ||::     |..||:       :...|...||...||||:|
  Rat    12 APLNP--EVDSPAGSA--------TYRE-----FVHRGY-------LDLMGASQHSLRALSWRRL 54

  Fly   308 QLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCI 372
            .||||||||||:||||||||||||||||||:.|...|||:|:||:.|||:|||||:.|||:|||:
  Rat    55 YLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCL 119

  Fly   373 LPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPP---- 433
            ||:||.|.|:|:::.||:|||:|||.|:|.||.|||.||..|||.|:.::.||||..:..|
  Rat   120 LPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPMDKP 184

  Fly   434 ------------------------------------------------------AAWSACVVLIP 444
                                                                  ||.::..:::|
  Rat   185 APVVPMSQVPPVTVSLSLASNLTPSSASVATTQQPPKACPPRQVCGSAHGPGWQAAMASTAIMVP 249

  Fly   445 VMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQME 483
            |.::|||||:|||||||:||.:.....:.||..|:.:::
  Rat   250 VGLVFMAFALHFYRSLVAHKTDRHKQELEELSRLQGELQ 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf186-F	NP_001137696.1	Orai-1	301..466	CDD:285140	105/222 (47%)
Orai3	NP_001014046.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		4/10 (40%)
Orai3	NP_001014046.1	Orai-1	48..271	CDD:285140	105/222 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351326
Domainoid	1	1.000	218	1.000	Domainoid score	I2568
eggNOG	1	0.900	-	-		E1_KOG4298
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3256
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002138
OrthoInspector	1	1.000	-	-		otm45155
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31501
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1421
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.850