Protein Alignment Orai and Orai2

DIOPT Version :10

• Sequence 1: NP_001137696.1
• Gene: Orai / 37040
• FlyBaseID: FBgn0041585
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_001163874.1
• Gene: Orai2 / 304592
• RGDID: 1310213
• Length: 313
• Species: Rattus norvegicus
• Alignment Length: 289
• Identity: 131/289 - (45%)
• Similarity: 167/289 - (57%)
• Gaps: 36/289 - (12%)

  Fly   210 TRRFTAQRDGS---PAYAASVAAASAAAAASAVAPIAPLAPLASIASPPFAAQPPPFQLRTYQQN 271
            |:.....|.|.   .|..||........:|....|:.|.||          |.|.|     ..:.
  Rat    37 TQTLATSRSGELEPSALRASQPGLVPTMSAELNVPMDPSAP----------ACPEP-----GHKG 86

  Fly   272 QSYRFQPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQ 336
            ..||...|..:....:|      :.||...||||||.||||||||||:|||||||||||||||||
  Rat    87 MDYRDWVRRSYLELVTS------NHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQ 145

  Fly   337 LDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIE 401
            |:.....|..:||||:.|||:|||||:.||:||||||||:|.|.|:|:::.:.||||||:|.|||
  Rat   146 LETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIE 210

  Fly   402 TAWAFSTLLGLILFLLEIAILCWVKFYDLSPP--------AAWSAC----VVLIPVMIIFMAFAI 454
            .||.|||:||::|||.|:.:|||:||..:...        ..|.|.    ::::||.:||:.|.|
  Rat   211 LAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTI 275

  Fly   455 HFYRSLVSHKYEVTVSGIRELEMLKEQME 483
            |||||||.||.|.....|.||..||.|::
  Rat   276 HFYRSLVRHKTERHNREIEELHKLKVQLD 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orai	NP_001137696.1	Orai-1	301..466	CDD:462291	104/176 (59%)
Orai2	NP_001163874.1	Orai-1	110..287	CDD:462291	104/176 (59%)