Protein Alignment Orai and Orai2

DIOPT Version :10

• Sequence 1: NP_001137696.1
• Gene: Orai / 37040
• FlyBaseID: FBgn0041585
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: XP_006504492.1
• Gene: Orai2 / 269717
• MGIID: 2443195
• Length: 264
• Species: Mus musculus
• Alignment Length: 261
• Identity: 125/261 - (47%)
• Similarity: 160/261 - (61%)
• Gaps: 33/261 - (12%)

  Fly   235 AASAVAPIAPLAPLASIASPPFAAQPPPFQLRTYQQNQSYRFQPRGHHRTASSSMSQSGEDLHSP 299
            :|....|:.|.||          |.|.|     ..:...||...|..:....:|      :.||.
Mouse    16 SAELNVPMDPSAP----------ACPEP-----GHKGMDYRDWVRRSYLELVTS------NHHSV 59

  Fly   300 TYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHML 364
            ..||||||.||||||||||:||||||||||||||||||:.....|..:||||:.|||:|||||:.
Mouse    60 QALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLF 124

  Fly   365 ALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYD 429
            ||:||||||||:|.|.|:|:::.:.||||||:|.|||.||.|||:||::|||.|:.:|||:||..
Mouse   125 ALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLP 189

  Fly   430 LSPP--------AAWSAC----VVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQM 482
            :...        ..|.|.    ::::||.:||:.|.||||||||.||.|.....|.||..||.|:
Mouse   190 VDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQL 254

  Fly   483 E 483
            :
Mouse   255 D 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orai	NP_001137696.1	Orai-1	301..466	CDD:462291	104/176 (59%)
Orai2	XP_006504492.1	Orai-1	61..238	CDD:462291	104/176 (59%)