DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment olf186-F and Orai1

DIOPT Version :9

Sequence 1:	NP_001137696.1	Gene:	olf186-F / 37040	FlyBaseID:	FBgn0041585	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_780632.1	Gene:	Orai1 / 109305	MGIID:	1925542	Length:	304	Species:	Mus musculus

Alignment Length:	377	Identity:	151/377 - (40%)
Similarity:	193/377 - (51%)	Gaps:	117/377 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 MRPQPNLGHAHQLPLTQTTQTAQPLHHQLPAHQLGNLRASNFVGSSRYLYHSQFNSNSPQTRRFT 214
            |.|:|                |.|     |:|....|..|.  |||        .|.|.::||.:
Mouse     1 MHPEP----------------APP-----PSHSNPELPVSG--GSS--------TSGSRRSRRRS 34

  Fly   215 AQRDGSPAYAASVAAASAAAAASAVAPIAPLAPLASIASPPFAAQPPPFQLRTYQQNQSYRFQPR 279
            .  ||.|:.|                  .||.|      ||.|...|.:..::|.:..|.
Mouse    35 G--DGEPSGA------------------PPLPP------PPPAVSYPDWIGQSYSEVMSL----- 68

  Fly   280 GHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVP 344
                           :.||...||||||.||||||||||:|||||||||||||||||||.|.:.|
Mouse    69 ---------------NEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYP 118

  Fly   345 PGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTL 409
            ||:||.|:.|||:|||||:.|||||||||||||.|.|:|:::.|.||||||:|.:||.||||||:
Mouse   119 PGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTV 183

  Fly   410 LGLILFLLEIAILCWVKFYDL----------SPP--------------------AAWSACVVLIP 444
            :|.:|||.|:.:||||||..|          .||                    ||.::..:::|
Mouse   184 IGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPAESVIVANHSDSSGITPGEAAAIASTAIMVP 248

  Fly   445 VMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQME----QDHLEHHNN 492
            ..::|:.||:||||||||||.:      |:.:.|.|..|    ||.|:|..:
Mouse   249 CGLVFIVFAVHFYRSLVSHKTD------RQFQELNELAEFARLQDQLDHRGD 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
olf186-F	NP_001137696.1	Orai-1	301..466	CDD:285140	112/194 (58%)
Orai1	NP_780632.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		24/105 (23%)
		Interaction with STIM1. /evidence=ECO:0000250	72..92		15/19 (79%)
		Orai-1	75..270	CDD:285140	112/194 (58%)
		Interaction with STIM1. /evidence=ECO:0000250	275..295		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847757
Domainoid	1	1.000	218	1.000	Domainoid score	I2640
eggNOG	1	0.900	-	-		E1_KOG4298
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3320
Isobase	1	0.950	-	0	Normalized mean entropy	S4680
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002138
OrthoInspector	1	1.000	-	-		otm43091
orthoMCL	1	0.900	-	-		OOG6_104915
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3030
SonicParanoid	1	1.000	-	-		X1421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.630