Protein Alignment Orai and orai2

DIOPT Version :10

• Sequence 1: NP_001137696.1
• Gene: Orai / 37040
• FlyBaseID: FBgn0041585
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: XP_012824392.1
• Gene: orai2 / 100380109
• XenbaseID: XB-GENE-5781666
• Length: 259
• Species: Xenopus tropicalis
• Alignment Length: 254
• Identity: 130/254 - (51%)
• Similarity: 170/254 - (66%)
• Gaps: 33/254 - (12%)

  Fly   258 AQPPPFQLRTYQQNQSYRFQPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSA 322
            ::|.|.||:  ::..||   |....|:....||.:.   ||...||||||.||||||||||:|||
 Frog    11 SRPCPPQLQ--EEEVSY---PEWISRSYVELMSLNE---HSMQALSWRKLYLSRAKLKASSRTSA 67

  Fly   323 LLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISL 387
            |||||||||||||||:.|...|||:||||:.|||:|||||:.|||||||||||||.|.|:|:::.
 Frog    68 LLSGFAMVAMVEVQLEADHAYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNS 132

  Fly   388 VHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPP---------------AAWS 437
            |.||||||:|.:||.||||||::|.:|||.|:.:||||||..::.|               ||.:
 Frog   133 VKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPVNSPKLSSNDTSTVSSGQAAAIA 197

  Fly   438 ACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQME----QDHLEHHNN 492
            :..:::|..::|:.||:||||||||||.:      |:.:.|.|..|    ||.|:|..:
 Frog   198 STAIMVPFGLVFIVFAVHFYRSLVSHKTD------RQFQELNELAELAQLQDQLDHRGD 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orai	NP_001137696.1	Orai-1	301..466	CDD:462291	110/179 (61%)
orai2	XP_012824392.1	Orai-1	46..226	CDD:462291	110/179 (61%)