DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grh and Tfcp2l1

DIOPT Version :9

Sequence 1:	NP_476845.2	Gene:	grh / 37038	FlyBaseID:	FBgn0259211	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_076244.2	Gene:	Tfcp2l1 / 81879	MGIID:	2444691	Length:	479	Species:	Mus musculus

Alignment Length:	511	Identity:	128/511 - (25%)
Similarity:	204/511 - (39%)	Gaps:	102/511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 WH----DFGRQNDAD-----------KIQIPKIFTNVGFR-----YHLESPISSSQRREDDRITY 924
            ||    .:.:.|...           |.:.|::....|.|     |.|.:..|.:.:..::.:||
Mouse     4 WHTQPEHYNQHNSGSYLRDVLALPIFKQEEPQLSPENGARLPPLQYVLCAATSPAVKLHEETLTY 68

  Fly   925 INKGQFYGITL---EYVHDAEKPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRIL 986
            :|:||.|.|.|   ..:.|.: .:....|||:|.::|.:.:....|.:..:.|  |......|||
Mouse    69 LNQGQSYEIRLLENRKLGDFQ-DLNTKYVKSIIRVVFHDRRLQYTEYQQLEGW--RWSRPGDRIL 130

  Fly   987 DADTKNSVGLVG-CIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQK--GVKGLPLHVQID 1048
            |.|...|||::. .......||:...|:| ...|...|.|.|:||:|:.:|  |.||:|..||||
Mouse   131 DIDIPLSVGILDPRASPTQLNAVEFLWDP-SKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQID 194

  Fly  1049 TFEDPRD---TAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHP--VTDR 1108
            ||:....   :...|...||||||..|||:||.:.:..:..||  ||..::|....|..  :|:.
Mouse   195 TFKQNESGDYSEHLHSASCQIKVFKPKGADRKQKTDREKMEKR--TAQEKEKYQPSYETTILTEC 257

  Fly  1109 SEF----YGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSNSH--SSLQSFYG 1167
            |.:    |...:...|....||       ...|           |..|||:.| |  ..|.....
Mouse   258 SPWPDVPYQANNTPSPSYNGSP-------NSFG-----------LREGNSSPN-HPVEPLPLGSD 303

  Fly  1168 HETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFGPP---- 1228
            |...|..::.|..: ||..:.:.....|.:....|:....:|.::..          .||.
Mouse   304 HLLPSASIQDAQQW-LHRNRFSQFCWLFASFSGADLLKMSRDDLVQV----------CGPADGIR 357

  Fly  1229 ---MKRGRMTPPTSERVMLYVRQENEE------------------VYTPLHVVPPTTIGLLNAIE 1272
               ..:||...|   ::.:||.||.|:                  ||..:.:...||:.|...|.
Mouse   358 LFNAIKGRNVRP---KMTIYVCQELEQNQLPLPQKQDDSGDNSLCVYHAIFLEELTTLELTEKIA 419

  Fly  1273 NKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIE-DDLYDVTL 1327
            :.|.|....|:.:||....||...:.::|:..:.:|..|:|...:.| :|.|.:.|
Mouse   420 SLYSIPPQHIHRVYRQGPAGIHVVVSNEMVQNFQDESCFILSTLKAESNDGYHIIL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	64/199 (32%)
Tfcp2l1	NP_076244.2	Mediate transcriptional repression	1..52		8/47 (17%)
		CP2	34..237	CDD:282385	65/206 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..248		10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..301		12/59 (20%)
		SAM2-like domain. /evidence=ECO:0000250\|UniProtKB:Q9NZI6	261..365		22/133 (17%)
		SAM_LBP9	310..376	CDD:188989	12/79 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810