DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grh and GRHL2

DIOPT Version :9

Sequence 1:	NP_476845.2	Gene:	grh / 37038	FlyBaseID:	FBgn0259211	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_079191.2	Gene:	GRHL2 / 79977	HGNCID:	2799	Length:	625	Species:	Homo sapiens

Alignment Length:	725	Identity:	213/725 - (29%)
Similarity:	329/725 - (45%)	Gaps:	178/725 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   668 LPPGPPPTSTTTFIAEPSYYREYFAPDGQGGYVPASTR---SLYGDVDVSVSQPGGVVTYEGRFA 729
            :|..||..:...:.:|...::.|..     ..:.|:|:   |:.||.| |.:..|.:..|.
Human    17 MPSDPPFNTRRAYTSEDEAWKSYLE-----NPLTAATKAMMSINGDED-SAAALGLLYDYY---- 71

  Fly   730 GSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSN--GGATPLYAKAIT 792
             .||....   |.||......|:.|:            ::....:.:.:||  ||...:......
Human    72 -KVPRDKR---LLSVSKASDSQEDQE------------KRNCLGTSEAQSNLSGGENRVQVLKTV 120

  Fly   793 AAGLTVD-------------LPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPV 844
            ...|:::             :..|:|    .||.|.....:.::.|:|.:.....:....|
Human   121 PVNLSLNQDHLENSKREQYSISFPES----SAIIPVSGITVVKAEDFTPVFMAPPVHYPRG---- 177

  Fly   845 SVNSIQQRTAVHGSQNSPTTSLV---------DTSTNGSTRSRPWHDFGRQN------DADKIQI 894
              :..:||..:.........||.         ..||..||.|..:.|...:.      .|::...
Human   178 --DGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMY 240

  Fly   895 PKIFTNVG-FRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAE---KPIKNTTVKSVIM 955
            .:  |:.| |:|.||:..|..|::.:..:||:||||||.|||....|.:   .||  :.|:||:|
Human   241 DQ--TSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPI--SKVRSVVM 301

  Fly   956 LMFREEKSPEDEIKAWQFWHSRQHSVKQRILD-ADTKNSVGLVGCIEEVSHNAIAVYWNPLESSA 1019
            ::|.|:|:.::::|.|::||||||:.|||:|| ||.|.|...:|.|||:::||::..|: :...|
Human   302 VVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWD-VNEEA 365

  Fly  1020 KINIAVQCLSTDFSSQKGVKGLPLHVQIDTFE-DPRDTAVFHRGYCQIKVFCDKGAERKTRDEER 1083
            ||.|.|.|||||||||||||||||.:||||:. :.|.....||.|||||||||||||||.|||||
Human   366 KIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEER 430

  Fly  1084 RAAKRK-----------MTATGR-------KKLDELYHPVTDRSEFYGMQDFAKPPVLFSP---A 1127
            :..::|           .::.|:       ||.|..|        |..|.|....||||.|   .
Human   431 KQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITY--------FKTMPDLHSQPVLFIPDVHF 487

  Fly  1128 EDMEKVGQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPT 1192
            .::::.||:                            :|  .||. :.:|.|
Human   488 ANLQRTGQV----------------------------YY--NTDD-EREGGS------------- 508

  Fly  1193 LKFHNHFPPDMQTDKKDHILDQNMLTSTPL-TDFGP-PMKRGRMTPPTSERVMLYVRQENEEVYT 1255
                              :|.:.|.  .|: .:||| |.|  :|....::||:||||:|.::|:.
Human   509 ------------------VLVKRMF--RPMEEEFGPVPSK--QMKEEGTKRVLLYVRKETDDVFD 551

  Fly  1256 PLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIED 1320
            .|.:..||..||:.||..||.:....|..:|:.:||||...:||::|..|.|||.|:|.::.:.:
Human   552 ALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVE 616

  Fly  1321 DLYDVTLTEL 1330
            . :.|||.|:
Human   617 G-FKVTLMEI 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	100/190 (53%)
GRHL2	NP_079191.2	Transcription activation. /evidence=ECO:0000250\|UniProtKB:Q8K5C0	1..93		20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..112		7/41 (17%)
		CP2	229..438	CDD:309593	104/213 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..453		4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	202	1.000	Domainoid score	I2986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm41194
orthoMCL	1	0.900	-	-		OOG6_104596
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.910