Protein Alignment grh and GRHL2

DIOPT Version :10

• Sequence 1: NP_476845.2
• Gene: grh / 37038
• FlyBaseID: FBgn0259211
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_079191.2
• Gene: GRHL2 / 79977
• HGNCID: 2799
• Length: 625
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 212/719 - (29%)
• Similarity: 332/719 - (46%)
• Gaps: 166/719 - (23%)

  Fly   668 LPPGPPPTSTTTFIAEPSYYREYFAPDGQGGYVPASTR---SLYGDVDVSVSQPGGVVTYEGRFA 729
            :|..||..:...:.:|...::.|..     ..:.|:|:   |:.||.| |.:..|.:..|.
Human    17 MPSDPPFNTRRAYTSEDEAWKSYLE-----NPLTAATKAMMSINGDED-SAAALGLLYDYY---- 71

  Fly   730 GSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSN--GGATPLYAKAIT 792
             .||....   |.||......|:.|:            ::....:.:.:||  ||...:......
Human    72 -KVPRDKR---LLSVSKASDSQEDQE------------KRNCLGTSEAQSNLSGGENRVQVLKTV 120

  Fly   793 AAGLTVD-------------LPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPV 844
            ...|:::             :..|:|    .||.|.....:.::.|:|.:.....:....|
Human   121 PVNLSLNQDHLENSKREQYSISFPES----SAIIPVSGITVVKAEDFTPVFMAPPVHYPRG---- 177

  Fly   845 SVNSIQQRTAVHGSQNSPTTSLV---------DTSTNGSTRSRPWHDFGRQN------DADKIQI 894
              :..:||..:.........||.         ..||..||.|..:.|...:.      .|::...
Human   178 --DGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMY 240

  Fly   895 PKIFTNVG-FRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAE---KPIKNTTVKSVIM 955
            .:  |:.| |:|.||:..|..|::.:..:||:||||||.|||....|.:   .||  :.|:||:|
Human   241 DQ--TSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPI--SKVRSVVM 301

  Fly   956 LMFREEKSPEDEIKAWQFWHSRQHSVKQRILD-ADTKNSVGLVGCIEEVSHNAIAVYWNPLESSA 1019
            ::|.|:|:.::::|.|::||||||:.|||:|| ||.|.|...:|.|||:::||::..|: :...|
Human   302 VVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWD-VNEEA 365

  Fly  1020 KINIAVQCLSTDFSSQKGVKGLPLHVQIDTFE-DPRDTAVFHRGYCQIKVFCDKGAERKTRDEER 1083
            ||.|.|.|||||||||||||||||.:||||:. :.|.....||.|||||||||||||||.|||||
Human   366 KIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEER 430

  Fly  1084 R---------AAKRKMTATGRKKLDELYHPVTDRSE---FYGMQDFAKPPVLFSP---AEDMEKV 1133
            :         |::.:..::...||..:  |:..:|:   |..|.|....||||.|   ..::::.
Human   431 KQNRKKGKGQASQTQCNSSSDGKLAAI--PLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRT 493

  Fly  1134 GQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNH 1198
            ||:                            :|  .||. :.:|.|
Human   494 GQV----------------------------YY--NTDD-EREGGS------------------- 508

  Fly  1199 FPPDMQTDKKDHILDQNMLTSTPL-TDFGP-PMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVP 1261
                        :|.:.|.  .|: .:||| |.|  :|....::||:||||:|.::|:..|.:..
Human   509 ------------VLVKRMF--RPMEEEFGPVPSK--QMKEEGTKRVLLYVRKETDDVFDALMLKS 557

  Fly  1262 PTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVT 1326
            ||..||:.||..||.:....|..:|:.:||||...:||::|..|.|||.|:|.::.:.:. :.||
Human   558 PTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEG-FKVT 621

  Fly  1327 LTEL 1330
            |.|:
Human   622 LMEI 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:461338	101/199 (51%)
GRHL2	NP_079191.2	Transcription activation. /evidence=ECO:0000250|UniProtKB:Q8K5C0	1..93		20/89 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..112		7/41 (17%)
		CP2	229..438	CDD:461338	103/213 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..453		4/24 (17%)