Protein Alignment grh and TFCP2

DIOPT Version :10

• Sequence 1: NP_476845.2
• Gene: grh / 37038
• FlyBaseID: FBgn0259211
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_005644.2
• Gene: TFCP2 / 7024
• HGNCID: 11748
• Length: 502
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 129/481 - (26%)
• Similarity: 203/481 - (42%)
• Gaps: 102/481 - (21%)

  Fly   903 FRYHLESPISSSQRREDDRITYINKGQFYGI-TLEYVHDAEKP-IKNTTVKSVIMLMFREEKSPE 965
            |:|.|.:..|.:.:..|:.:||:|:||.|.| .|:.....|.| |....|||:..::|.:.:...
Human    67 FQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIFRVVFHDRRLQY 131

  Fly   966 DEIKAWQFWHSRQHSVKQRILDADTKNSVGLVG-CIEEVSHNAIAVYWNPLESSAKINIAVQCLS 1029
            .|.:..:.|  |.:....||||.|...|||::. .......|.:...|:|.:.:: :.|.|.|:|
Human   132 TEHQQLEGW--RWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPAKRTS-VFIQVHCIS 193

  Fly  1030 TDFSSQK--GVKGLPLHVQIDTFEDPRD---TAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRK 1089
            |:|:.:|  |.||:|..||||||::..:   |...|...||||||..|||:||.:.:..:..||
Human   194 TEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKR- 257

  Fly  1090 MTATGRKKLDELYHPVTDRSEFYGMQDFAKPPVL--FSPAEDMEKVGQLGIGAATGMTFNPLSNG 1152
               |..:|  |.|.|..:.:            :|  .||..::..|.            |..|.|
Human   258 ---TPHEK--EKYQPSYETT------------ILTECSPWPEITYVN------------NSPSPG 293

  Fly  1153 NSNSNSHSSLQSFYG---HETDSPD------LKGASP----FLLHGQKVATPTLKFHNHFPPDMQ 1204
            .::|:|..||....|   |:.:.|.      |...:|    ..||..:.:|.|..|.|....|:.
Human   294 FNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLL 358

  Fly  1205 TDKKDHILDQNMLTSTPLTDFGPP-------MKRGRMTPPTSERVMLYVRQENEE---------- 1252
            ...:|.::.          ..||.       ..:|||..|   |:.:||.||:.:
Human   359 KLTRDDVIQ----------ICGPADGIRLFNALKGRMVRP---RLTIYVCQESLQLREQQQQQQQ 410

  Fly  1253 ---------------VYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMI 1302
                           ||..:::...|.:.|...|...:.||...|:.||:....||...|.|:||
Human   411 QQQKHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDEMI 475

  Fly  1303 SFYCNEDIFLLEVQQIE-DDLYDVTL 1327
            ..:..|..|:|:..:.| :|.|.:.|
Human   476 QNFQEEACFILDTMKAETNDSYHIIL 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:461338	65/193 (34%)
TFCP2	NP_005644.2	CP2	52..259	CDD:461338	66/198 (33%)
		DNA-binding	133..395		83/307 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..268		12/35 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..325		7/30 (23%)
		SAM_TFCP2	329..395	CDD:188988	17/78 (22%)