Protein Alignment grh and GRHL3

DIOPT Version :9

• Sequence 1: NP_476845.2
• Gene: grh / 37038
• FlyBaseID: FBgn0259211
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_937817.3
• Gene: GRHL3 / 57822
• HGNCID: 25839
• Length: 626
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 168/533 - (31%)
• Similarity: 242/533 - (45%)
• Gaps: 136/533 - (25%)

  Fly   819 NIQQSFDYTELCQPGTLIDANGSIPVSVNSIQQRTAVH----GSQNS---PTTSLVDTSTNGSTR 876
            |:..:.:|.:|.:...|:...|::|....:........    ||.:|   |||.:.|   |||..
Human   116 NVSGTPEYPDLLKKNNLMSLEGALPTPGKAAPLPAGPSKLEAGSVDSYLLPTTDMYD---NGSLN 177

  Fly   877 S-----------RPWHDFGRQNDA---DKIQIPKIFTNV------------------GFRYHLES 909
            |           :.|     |.|:   |..|...:|.::                  .|.|.|.|
Human   178 SLFESIHGVPPTQRW-----QPDSTFKDDPQESMLFPDILKTSPEPPCPEDYPSLKSDFEYTLGS 237

  Fly   910 PISSSQRREDDRITYINKGQFYGITLEYVHDAE-KPIKNTTVKSVIMLMFREEKSPEDEIKAWQF 973
            |.:...:..:..:.|:||||||.:||......: ..:.:..||||:|::|..||.|.::::.|:.
Human   238 PKAIHIKSGESPMAYLNKGQFYPVTLRTPAGGKGLALSSNKVKSVVMVVFDNEKVPVEQLRFWKH 302

  Fly   974 WHSRQHSVKQRILD-ADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKG 1037
            |||||.:.|||::| ||.|.:...|..||||::||::..|| :...||:.|.|.|||||||||||
Human   303 WHSRQPTAKQRVIDVADCKENFNTVEHIEEVAYNALSFVWN-VNEEAKVFIGVNCLSTDFSSQKG 366

  Fly  1038 VKGLPLHVQIDTFEDPRDT-AVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTA--------- 1092
            |||:||::||||::....| .:.||..||||:|||||||||.||:||:..:||:..
Human   367 VKGVPLNLQIDTYDCGLGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNSGVK 431

  Fly  1093 ----TGRKKLDELY-HPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSNG 1152
                :|.:..:..| .|.|         |...|||||.|......:.:.| |||.       |.|
Human   432 GCLLSGFRGNETTYLRPET---------DLETPPVLFIPNVHFSSLQRSG-GAAP-------SAG 479

  Fly  1153 NSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQNML 1217
            .|:||.             .|..:..|||          |.:|.
Human   480 PSSSNR-------------LPLKRTCSPF----------TEEFE--------------------- 500

  Fly  1218 TSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKISTTSI 1282
               ||     |.|:.:  ....:||:||||:|.|||:..|.:..|...||.|||..||.....:|
Human   501 ---PL-----PSKQAK--EGDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGFPEENI 555

  Fly  1283 NNIYRTNKKGITA 1295
            ..:|:..|:|.|:
Human   556 YKVYKKCKRGETS 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	89/188 (47%)
GRHL3	NP_937817.3	Transcription activation. /evidence=ECO:0000269|PubMed:12549979	30..95
		CP2	210..421	CDD:282385	91/211 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	202	1.000	Domainoid score	I2986
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm41194
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.910