Protein Alignment grh and grhl2a

DIOPT Version :9

• Sequence 1: NP_476845.2
• Gene: grh / 37038
• FlyBaseID: FBgn0259211
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_001313462.1
• Gene: grhl2a / 555744
• ZFINID: ZDB-GENE-050913-123
• Length: 593
• Species: Danio rerio
• Alignment Length: 701
• Identity: 207/701 - (29%)
• Similarity: 310/701 - (44%)
• Gaps: 174/701 - (24%)

  Fly   676 STTTFIAEPSYYREYFAPDGQGGYVPASTR---SLYGDVDVSVSQPGGVVTYEGRFAGSVPPPAT 737
            |...|.:|...::.|..     ..:.|:|:   |:.||.| ||:..|.:..|.     .||
Zfish    21 SRRAFTSEDEAWKSYLE-----NPLTAATKAMMSINGDED-SVAALGILYDYY-----KVP---- 70

  Fly   738 TTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNGGATPLYAKAITAAGLTVDLPS 802
                                 ::::....|:..:.|.:...|..|......:......|.|:|
Zfish    71 ---------------------KEKRLLPVHKLPEDHEKSRISQDGVESAENRIHVLKSLPVNL-- 112

  Fly   803 PDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPV--------SVNSIQQRTAVHGSQ 859
                    ::.| |..|.|..|        ||:...:|.:..        |.:|..|:...|.:.
Zfish   113 --------SLNP-DSENKQDLF--------GTVPAEDGVVATVKPEVYAQSFSSHHQQLHYHRTP 160

  Fly   860 NSPTTSLVDTSTNGSTR-------SRPWHDF--GRQNDADKIQIP-----KIFTN--VG---FRY 905
            ..|  .|.|:.:....|       |.|...|  ....|..:.::|     :.||:  .|   |:|
Zfish   161 YHP--HLQDSVSVSHDRYMKDDQCSTPDSTFEDSYPEDPMRYRVPTTPAAEDFTHEQAGLNMFQY 223

  Fly   906 HLESPISSSQRREDDRITYINKGQFYGITLEYVHDAEKPIKN--TTVKSVIMLMFREEKSPEDEI 968
            ::|:..|..::..|..:.|:||||||||||... .|.|.:::  :.|::|:|::|.:||..::::
Zfish   224 NIEASRSVREKAADGPMVYLNKGQFYGITLSET-GANKGLRHPISKVRTVVMVVFGQEKCRDEQL 287

  Fly   969 KAWQFWHSRQHSVKQRILD-ADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDF 1032
            |.|.:||:|||:.|||:|| ||.|.|...:|.|||:::||::..|: :...||:.|.|.||||||
Zfish   288 KHWNYWHTRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWD-VNEEAKVFITVNCLSTDF 351

  Fly  1033 SSQKGVKGLPLHVQIDTFE-DPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKM---TAT 1093
            |||||||||||.:||||:. :.|.....||.|.|||||||||||||.||||::..::|:   |..
Zfish   352 SSQKGVKGLPLMIQIDTYSYNNRSNRPIHRAYAQIKVFCDKGAERKIRDEEKKQLRKKVKGQTVG 416

  Fly  1094 G------RKKLDELYHPVTDRSEFYGMQDFAKPPVLFSP---AEDMEKVGQLGIGAATGMTFNPL 1149
            |      |..|..|.....|.:.|..|.|....||||.|   ..::::.||
Zfish   417 GHGQDGKRGNLASLPPKRPDITLFKAMTDLESQPVLFIPDVHLNNLQRAGQ-------------- 467

  Fly  1150 SNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQ 1214
                        :.||...|.::..:....||                      .|.:.|
Zfish   468 ------------VFSFGVEEMENDGVAVKRPF----------------------GTSEAD----- 493

  Fly  1215 NMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKIST 1279
                       .||.|..|    ...:|:||||:|.:||:..|.:..||...||.||..||.:..
Zfish   494 -----------SPPTKYSR----EERKVLLYVRREADEVFDALMLRSPTLKSLLEAISGKYSVPV 543

  Fly  1280 TSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTEL 1330
            ..:..||:.:||||...:||::|..|||||.|:|.:.. ..|.:.|||||:
Zfish   544 EKMTKIYKKSKKGILVNMDDNIIEHYCNEDTFILAIDN-HADCFRVTLTEI 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	93/189 (49%)
grhl2a	NP_001313462.1	CP2	201..411	CDD:282385	98/211 (46%)
		MIEAP	441..>515	CDD:292645	26/141 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3008
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm24628
orthoMCL	1	0.900	-	-		OOG6_104596
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.810