DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grh and grhl2

DIOPT Version :9

Sequence 1:	NP_476845.2	Gene:	grh / 37038	FlyBaseID:	FBgn0259211	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001011338.1	Gene:	grhl2 / 496802	XenbaseID:	XB-GENE-485995	Length:	619	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	192/552 - (34%)
Similarity:	279/552 - (50%)	Gaps:	115/552 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   814 PRDQTNIQQSFDYTEL-CQPGTLIDANGSIPVSVNSIQQRTAVHGSQNSPTTSLVD--TSTNGST 875
            |.....:.::.::|.: ..|.....::|..|..|...|....|| |..:.:..|.|  .||..||
Frog   148 PASAVTVVKAEEFTPVFMAPSVPYRSDGEEPRGVIFEQTHFGVH-SITTHSDYLKDDQRSTPDST 211

  Fly   876 RSRPWHDFGRQNDADKIQIPKIFT---------NVGFRYHLESPISSSQRREDDRITYINKGQFY 931
            .:..:     :...:|.:.|.:.|         :..|:|.||:..|..|::.:..:||:||||||
Frog   212 YNESF-----KETTEKYRTPSVGTEEFLYEQTASSTFQYTLEATKSLRQKQGEGPMTYLNKGQFY 271

  Fly   932 GITLEYVHDAEKPIKN--TTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRILD-ADTKNS 993
            .|||... .|.|..::  :.|:||||::|.|:|:.::::|.|::||||||:.|||:|| ||.|.|
Frog   272 AITLSET-GANKCFRHPISKVRSVIMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKES 335

  Fly   994 VGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLPLHVQIDTFE-DPRDTA 1057
            ...:|.|||:::||::..|: :...|||.|.|.|||||||||||||||||.:||||:. :.|...
Frog   336 FNTIGNIEEIAYNAVSFTWD-VNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNK 399

  Fly  1058 VFHRGYCQIKVFCDKGAERKTRDEERR---------AAKRKMTATGRKKLDELYHPVTDRSE--- 1110
            ..||.|||||||||||||||.|||||:         ||:.:...:...||..:  |:..:|:
Frog   400 PIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKSQAAQAQCNNSADGKLSAV--PLQKKSDITF 462

  Fly  1111 FYGMQDFAKPPVLFSP---AEDMEKVGQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDS 1172
            |..|.|....||||.|   ..::::.||:                            ||  .||.
Frog   463 FKTMTDLDVQPVLFIPDVHFGNLQRTGQV----------------------------FY--NTDD 497

  Fly  1173 PDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFGPP----MKRGR 1233
             |::|.                                :|.:.:|.... .|:|||    ||.|
Frog   498 -DIEGG--------------------------------VLVKRLLRPVD-EDYGPPAPKQMKEG- 527

  Fly  1234 MTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKID 1298
                 |.:|:||||:|.:||:..|.:..||..|||.||..||.|....|..||:.:||||...:|
Frog   528 -----SRKVLLYVRKETDEVFDALMLKYPTVKGLLEAISEKYGIPVEKIVKIYKKSKKGILVNMD 587

  Fly  1299 DDMISFYCNEDIFLLEVQQIEDDLYDVTLTEL 1330
            |::|..|.|||.|:|.|:.:.:..|.:||||:
Frog   588 DNIIEHYSNEDTFILNVESLAEQGYKITLTEI 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	102/198 (52%)
grhl2	NP_001011338.1	Transcription activation. /evidence=ECO:0000250\|UniProtKB:Q8K5C0	1..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..147
		CP2	224..433	CDD:367976	102/210 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..444		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm48406
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.010