DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grh and Ubp1

DIOPT Version :9

Sequence 1:	NP_476845.2	Gene:	grh / 37038	FlyBaseID:	FBgn0259211	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_006244024.2	Gene:	Ubp1 / 301038	RGDID:	1564700	Length:	593	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	134/588 - (22%)
Similarity:	223/588 - (37%)	Gaps:	128/588 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   801 PSPDSGIGTDAITPRDQTNIQQ--------------SFDYTELCQPGTLIDANGSIPVSVNSIQQ 851
            |.|.||....|..|..:|...:              |.|  |:.:.|.:.|.:.|:    :.|.|
  Rat    59 PRPPSGRARGARAPSPRTRRPRCAGRRRGRKMAWVLSMD--EVIESGLVHDFDSSL----SGIGQ 117

  Fly   852 RTAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGRQNDADKIQIPKIFTNVGFRYHLESPISSSQR 916
            .........|...:|.......|:.|.         :|:....|       |:|.:.:..|.:.:
  Rat   118 ELGAGAYSMSDVLALPIFKQEDSSLSL---------EAEAKHPP-------FQYVMCAATSPAVK 166

  Fly   917 REDDRITYINKGQFYGITLEYVHDAEK-----PIKNTTVKSVIMLMFREEK---SPEDEIKAWQF 973
            ..|:.:||:|:||.|.|.:   .|..|     .|....|||:|.::|.:.:   :...:::.|:
  Rat   167 LHDETLTYLNQGQSYEIRM---LDNRKMGDVPEISGKLVKSIIRVVFHDRRLQYTEHQQLEGWK- 227

  Fly   974 WHSRQHSVKQRILDADTKNSVGLVGCIEEVSH-NAIAVYWNPLESSAKINIAVQCLSTDFSSQK- 1036
            |    :....|:||.|...|||::......|. ||:...|:|.:.::.. |.|.|:||:|:.:|
  Rat   228 W----NRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAF-IQVHCISTEFTPRKH 287

  Fly  1037 -GVKGLPLHVQIDTF---EDPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKK 1097
             |.||:|..:|:|||   |:...|...|...||||||..|||:||.:::..:..||    |..:|
  Rat   288 GGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKNDREKMEKR----TAHEK 348

  Fly  1098 LDELYHPVTDRSEFYGMQDFAKPPVLF-----SPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSN 1157
              |.|.|..|.:.......:...|..:     |||.......|.....       |.||.:|.::
  Rat   349 --EKYQPSYDTTILTECSPWPDTPTAYVNNSPSPAPTFTSSQQSTCSV-------PDSNSSSPNH 404

  Fly  1158 SHSSLQSFYGHETD-SPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILD-------- 1213
            ....:....|.:.. |...:....:||. .:.::.|..|.|....|:....|:.::.
  Rat   405 QGDGVAQASGEQIQPSATTQETQQWLLK-NRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGI 468

  Fly  1214 --QNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEE-----------------------V 1253
              .|.|.|             |...|   |:.:||.||...                       |
  Rat   469 RLYNSLKS-------------RSVRP---RLTIYVCQEQPSSAVPQGQPQAAGSGGEGGAGTPCV 517

  Fly  1254 YTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQI 1318
            |..:::.......:...:.:.:.|....||.:||....||...:.|.|:..:.:|..||....:.
  Rat   518 YHAIYLEEMVASEVARKLASVFNIPFHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKA 582

  Fly  1319 EDD 1321
            |::
  Rat   583 ENN 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	63/199 (32%)
Ubp1	XP_006244024.2	CP2	139..343	CDD:398291	66/228 (29%)
Ubp1	XP_006244024.2	SAM_LBP1	422..488	CDD:188987	14/82 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810