DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grh and Grhl3

DIOPT Version :9

Sequence 1:	NP_476845.2	Gene:	grh / 37038	FlyBaseID:	FBgn0259211	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_008762438.1	Gene:	Grhl3 / 298555	RGDID:	1308320	Length:	603	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	171/576 - (29%)
Similarity:	255/576 - (44%)	Gaps:	152/576 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   819 NIQQSFDYTELCQPGTLIDANGSIPVSVNSIQQRTAV---------HGSQNS---PTTSLVDTST 871
            |:..|.|||:..:...|:...|::|.     ..:|:.         .||.:|   ||:.:.|.|:
  Rat   116 NVSGSPDYTDQLKKNNLLGLEGALPT-----PGKTSTLPPGPSKLEAGSMDSYLLPTSDMYDNSS 175

  Fly   872 --------NGSTRSRPWHDFGRQNDA---DKIQIPKIFTNV------------------GFRYHL 907
                    :|...::.|     |.|:   |..|...:|.::                  .|.|.|
  Rat   176 LNSLFESIHGVPPTQRW-----QPDSTFKDDPQESLLFPDILKTSPEAPCPEDYPSLKSDFEYTL 235

  Fly   908 ESPISSSQRREDDRITYINKGQFYGITLEYVHDAE-KPIKNTTVKSVIMLMFREEKSPEDEIKAW 971
            .||.:...:..:..:.|:||||||.:||......: ..:.::.||||:|::|..:|.|.::::.|
  Rat   236 GSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLSLSSSKVKSVVMIVFDNDKVPVEQLRFW 300

  Fly   972 QFWHSRQHSVKQRILD-ADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQ 1035
            :.|||||.:.|||::| ||.|.:...|..||||::||::..|| :...||:.|.|.|||||||||
  Rat   301 RHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWN-VNEEAKVFIGVNCLSTDFSSQ 364

  Fly  1036 KGVKGLPLHVQIDTFEDPRDT-AVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLD 1099
            |||||:||::||||::....| .:.||..||||:|||||||||.||:||:..:||:..
  Rat   365 KGVKGVPLNLQIDTYDCGAGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKC------- 422

  Fly  1100 ELYHPVTDRSEFYGMQ-------------------DFAKPPVLFSPAEDMEKVGQLGIGAATGMT 1145
                  .|.|...|::                   |....||||.|
  Rat   423 ------PDSSNNAGIKGCLLSGFRGNETTYLRPEADLETQPVLFIP------------------- 462

  Fly  1146 FNPLSNGNSNSNSH-SSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKD 1209
                       |.| ||||        .|.  |..|...|......|..:
  Rat   463 -----------NLHFSSLQ--------RPG--GVVPSAGHSSSDRLPLKR--------------- 491

  Fly  1210 HILDQNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENK 1274
                    |.:|..:...|:...:......:||:||||:|.|||:..|.:..|...||.|||..|
  Rat   492 --------TCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEK 548

  Fly  1275 YKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTEL 1330
            |.....:|..:|:..|:||...:|:::|..|.|...|||::.:: |....:.|.||
  Rat   549 YGFPEENICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGEL-DGKIQIILKEL 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	88/188 (47%)
Grhl3	XP_008762438.1	CP2	210..421	CDD:282385	90/211 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3032
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm45331
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.910