Protein Alignment grh and TFCP2L1

DIOPT Version :10

• Sequence 1: NP_476845.2
• Gene: grh / 37038
• FlyBaseID: FBgn0259211
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_055368.1
• Gene: TFCP2L1 / 29842
• HGNCID: 17925
• Length: 479
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 124/486 - (25%)
• Similarity: 209/486 - (43%)
• Gaps: 93/486 - (19%)

  Fly   886 QNDADKIQIPKIFTNVGFRYHLESPISSSQRREDDRITYINKGQFYGITL---EYVHDAEKPIKN 947
            :|:|   ::|.:      :|.|.:..|.:.:..::.:||:|:||.|.|.|   ..:.|.: .:..
Human    39 ENEA---RLPPL------QYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQ-DLNT 93

  Fly   948 TTVKSVIMLMFREEK---SPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLVG-CIEEVSHNAI 1008
            ..|||:|.::|.:.:   :...:::.|: | ||.   ..||||.|...|||::. .......||:
Human    94 KYVKSIIRVVFHDRRLQYTEHQQLEGWR-W-SRP---GDRILDIDIPLSVGILDPRASPTQLNAV 153

  Fly  1009 AVYWNPLESSAKINIAVQCLSTDFSSQK--GVKGLPLHVQIDTF---EDPRDTAVFHRGYCQIKV 1068
            ...|:|.:.::.. |.|.|:||:|:.:|  |.||:|..||||||   |:...|...|...|||||
Human   154 EFLWDPAKRASAF-IQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKV 217

  Fly  1069 FCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHP--VTDRSEF----YGMQDFAKPPVLFSPA 1127
            |..|||:||.:.:..:..||  ||..::|....|..  :|:.|.:    |.:.....|....||
Human   218 FKPKGADRKQKTDREKMEKR--TAQEKEKYQPSYETTILTECSPWPDVAYQVNSAPSPSYNGSP- 279

  Fly  1128 EDMEKVGQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPT 1192
                  ...|:|.......:|:          .:|.....|...|..::.|..: ||..:.:...
Human   280 ------NSFGLGEGNASPTHPV----------EALPVGSDHLLPSASIQDAQQW-LHRNRFSQFC 327

  Fly  1193 LKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFGPP-------MKRGRMTPPTSERVMLYVRQEN 1250
            ..|.:....|:....:|.::.          ..||.       ..:||...|   ::.:||.||.
Human   328 RLFASFSGADLLKMSRDDLVQ----------ICGPADGIRLFNAIKGRNVRP---KMTIYVCQEL 379

  Fly  1251 EE------------------VYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKI 1297
            |:                  ||..:.:...||:.|:..|.|.|.||...|:.:||....||...:
Human   380 EQNRVPLQQKRDGSGDSNLSVYHAIFLEELTTLELIEKIANLYSISPQHIHRVYRQGPTGIHVVV 444

  Fly  1298 DDDMISFYCNEDIFLLEVQQIE-DDLYDVTL 1327
            .::|:..:.:|..|:|...:.| :|.|.:.|
Human   445 SNEMVQNFQDESCFVLSTIKAESNDGYHIIL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:461338	65/197 (33%)
TFCP2L1	NP_055368.1	CP2	48..237	CDD:461338	64/195 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..245		9/27 (33%)
		SAM2-like domain. /evidence=ECO:0000305|PubMed:26906118	261..365		18/131 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..301		7/46 (15%)
		SAM_LBP9	310..376	CDD:188989	12/79 (15%)